About   Help   FAQ
Kcnj4 Gene Detail
Summary
  • Symbol
    Kcnj4
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 4
  • Synonyms
    IRK3, Kcnf2, Kir 2.3, MB-IRK3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104743
    NCBI Gene: 16520
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79367915-79389442 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.74 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    552 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104743
 protein coding gene Chr15:79364427-79396712 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022075
 protein coding gene Chr15:79758537-79783037 (-)
A/J MGP_AJ_G0022036
 protein coding gene Chr15:77005963-77027730 (-)
AKR/J MGP_AKRJ_G0022011
 protein coding gene Chr15:79155420-79176830 (-)
BALB/cJ MGP_BALBcJ_G0022042
 protein coding gene Chr15:77001373-77024334 (-)
C3H/HeJ MGP_C3HHeJ_G0021813
 protein coding gene Chr15:79148694-79170080 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022485
 protein coding gene Chr15:82905148-82926667 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020015
 protein coding gene Chr15:73485237-73507076 (-)
CAST/EiJ MGP_CASTEiJ_G0021334
 protein coding gene Chr15:79858581-79881390 (-)
CBA/J MGP_CBAJ_G0021778
 protein coding gene Chr15:85480493-85503418 (-)
DBA/2J MGP_DBA2J_G0021907
 protein coding gene Chr15:76494084-76515480 (-)
FVB/NJ MGP_FVBNJ_G0021885
 protein coding gene Chr15:75519332-75541563 (-)
LP/J MGP_LPJ_G0021975
 protein coding gene Chr15:79950644-79972197 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021905
 protein coding gene Chr15:90587601-90609091 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022499
 protein coding gene Chr15:79167705-79189191 (-)
PWK/PhJ MGP_PWKPhJ_G0021076
 protein coding gene Chr15:76503469-76525445 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020913
 protein coding gene Chr15:78990443-79013918 (-)
WSB/EiJ MGP_WSBEiJ_G0021386
 protein coding gene Chr15:79552148-79573695 (-)



Homology
more
  • Human Ortholog
    KCNJ4, potassium inwardly rectifying channel subfamily J member 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ4, potassium inwardly rectifying channel subfamily J member 4
  • Synonyms
    HIR, HIRK2, HRK1, IRK-3, IRK3, Kir2.3
  • Links
    NCBI Gene ID: 3761
    neXtProt AC: NX_P48050
    UniProt: P48050

  • Chr Location
    22q13.1; chr22:38426327-38455199 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    3 involving Kcnj4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    19 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    49
  • cDNA Data
    11
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044216 Ensembl Gene Model | MGI Sequence Detail 21528 C57BL/6J ±  kb
transcript ENSMUST00000057801 Ensembl | MGI Sequence Detail 2152 Not Applicable  
polypeptide ENSMUSP00000094075 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000002057 inward rectifier potassium channel 4
    (term hierarchy)
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR041647 Inward rectifier potassium channel, C-terminal
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003273 Potassium channel, inwardly rectifying, Kir2.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
    IPR040445 Potassium channel, inwardly rectifying, transmembrane domain
  • GlyGen
    P52189 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 23
    Genomic 8
    cDNA 11
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16673, MGD-MRK-28034
References
more
  • Summaries
    All 68
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 9
    Phenotypes 26
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory