Nfkbib MGI Mouse Gene Detail - MGI:104752 - nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta

Symbol

Nfkbib
Name

nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta
Synonyms

IKappaBbeta, IkB

Feature Type

protein coding gene
IDs

MGI:104752
NCBI Gene: 18036
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr7:28457676-28466069 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.91 cM, cytoband A3-B3
Mapping Data

3 experiments

SNPs within 2kb

329 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104752	protein coding gene	Chr7:28457676-28466937 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031959	protein coding gene	Chr7:27595074-27606423 (-)
A/J	MGP_AJ_G0031937	protein coding gene	Chr7:26905119-26916072 (-)
AKR/J	MGP_AKRJ_G0031869	protein coding gene	Chr7:27597880-27607141 (-)
BALB/cJ	MGP_BALBcJ_G0031944	protein coding gene	Chr7:27064973-27074205 (-)
C3H/HeJ	MGP_C3HHeJ_G0031663	protein coding gene	Chr7:27973572-27982833 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032408	protein coding gene	Chr7:28497390-28506651 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029460	protein coding gene	Chr7:27966502-27975597 (-)
CAST/EiJ	MGP_CASTEiJ_G0030998	protein coding gene	Chr7:21293302-21302583 (-)
CBA/J	MGP_CBAJ_G0031629	protein coding gene	Chr7:29765398-29775151 (-)
DBA/2J	MGP_DBA2J_G0031781	protein coding gene	Chr7:26658003-26667264 (-)
FVB/NJ	MGP_FVBNJ_G0031738	protein coding gene	Chr7:26736271-26745907 (-)
LP/J	MGP_LPJ_G0031861	protein coding gene	Chr7:27918122-27927383 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031774	protein coding gene	Chr7:29236653-29245914 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032438	protein coding gene	Chr7:27076385-27085644 (-)
PWK/PhJ	MGP_PWKPhJ_G0030723	protein coding gene	Chr7:21682427-21691777 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030556	protein coding gene	Chr7:18096574-18105835 (-)
WSB/EiJ	MGP_WSBEiJ_G0031107	protein coding gene	Chr7:27448427-27457785 (-)

Human Ortholog

NFKBIB, NFKB inhibitor beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFKBIB, NFKB inhibitor beta
Synonyms

IKBB, TRIP9
Links

HGNC:7798

NCBI Gene ID: 4793

neXtProt AC: NX_Q15653

UniProt: Q15653
Chr Location

19q13.2; chr19:38899666-38908893 (+) GRCh38

MGI Vertebrate Homology

Nfkbib stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFKBIB
Gene Tree

Nfkbib

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Phenotype Summary

18 phenotypes from 3 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

3
Gene trapped

5
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for one knock-out allele exhibit decreased susceptibility to endotoxin shock and induced arthritis.

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All GO Annotations

9
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

34
cDNA Data

7
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nfkbib

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All Sequences

47
RefSeq

4
UniProt

5
CCDS

CCDS21054.1

Ensembl

ENSMUSG00000030595 (Evidence)
NCBI Gene

18036

			Length	Strain/Species	Flank
genomic	18036	NCBI Gene Model \| MGI Sequence Detail	8394	C57BL/6J	± kb
transcript	NM_010908	RefSeq \| MGI Sequence Detail	2065	C57BL/6
polypeptide	Q60778	UniProt \| EBI \| MGI Sequence Detail	359	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000003294 NF-kappa-B inhibitor beta

(term hierarchy)
PDB

1K3Z, 1OY3
InterPro Domains

IPR002110 Ankyrin repeat

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 9

Genomic 1

cDNA 7

Other 1

Microarray probesets 3

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MGD-MRK-28043

Summaries

All 66

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 12
Earliest

J:23294 Thompson JE, et al., I kappa B-beta regulates the persistent response in a biphasic activation of NF-kappa B. Cell. 1995 Feb 24;80(4):573-82
Latest

J:321300 Adelaja A, et al., Six distinct NFkappaB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses. Immunity. 2021 May 11;54(5):916-930.e7

TSS for Nfkbib:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr71576	Chr7:28466549-28466579 (-)	-495 bp
Tssr71575	Chr7:28466537-28466542 (-)	-471 bp
Tssr71574	Chr7:28466401-28466411 (-)	-337 bp
Tssr71573	Chr7:28465894-28465935 (-)	154 bp
Tssr71572	Chr7:28465870-28465893 (-)	187 bp
Tssr71571	Chr7:28465856-28465867 (-)	207 bp
Tssr71570	Chr7:28465700-28465748 (-)	345 bp
Tssr71569	Chr7:28465616-28465650 (-)	436 bp
Tssr71568	Chr7:28464036-28464042 (-)	2,030 bp
Tssr71567	Chr7:28461553-28461562 (-)	4,511 bp
Tssr71566	Chr7:28461259-28461271 (-)	4,804 bp
Tssr71565	Chr7:28461195-28461243 (-)	4,850 bp
Tssr71564	Chr7:28461130-28461153 (-)	4,927 bp
Tssr71563	Chr7:28459382-28459413 (-)	6,671 bp
Tssr71562	Chr7:28459369-28459381 (-)	6,694 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24