Sik1 MGI Mouse Gene Detail - MGI:104754

Symbol

Sik1
Name

salt inducible kinase 1
Synonyms

Msk, Snf1lk

Feature Type

protein coding gene
IDs

MGI:104754
NCBI Gene: 17691
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr17:32063224-32074778 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 17.25 cM
Mapping Data

2 experiments

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104754	protein coding gene	Chr17:32063222-32074808 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023495	protein coding gene	Chr17:31646499-31661166 (-)
A/J	MGP_AJ_G0023452	protein coding gene	Chr17:30604545-30616169 (-)
AKR/J	MGP_AKRJ_G0023418	protein coding gene	Chr17:30874020-30885396 (-)
BALB/cJ	MGP_BALBcJ_G0023457	protein coding gene	Chr17:30681912-30693194 (-)
C3H/HeJ	MGP_C3HHeJ_G0023219	protein coding gene	Chr17:31247077-31260316 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023900	protein coding gene	Chr17:32740117-32752699 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021374	protein coding gene	Chr17:27723394-27734856 (-)
CAST/EiJ	MGP_CASTEiJ_G0022720	protein coding gene	Chr17:31285888-31333743 (-)
CBA/J	MGP_CBAJ_G0023194	protein coding gene	Chr17:34139480-34153386 (-)
DBA/2J	MGP_DBA2J_G0023324	protein coding gene	Chr17:29990129-30001591 (-)
FVB/NJ	MGP_FVBNJ_G0023294	protein coding gene	Chr17:29810857-29823094 (-)
LP/J	MGP_LPJ_G0023402	protein coding gene	Chr17:31863456-31874793 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023312	protein coding gene	Chr17:33236594-33248076 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023942	protein coding gene	Chr17:31239533-31252962 (-)
PWK/PhJ	MGP_PWKPhJ_G0022469	protein coding gene	Chr17:28848649-28880249 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0022288	protein coding gene	Chr17:29226010-29237764 (-)
WSB/EiJ	MGP_WSBEiJ_G0022782	protein coding gene	Chr17:31211625-31224015 (-)

Human Ortholog

SIK1, salt inducible kinase 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SIK1, salt inducible kinase 1
Synonyms

DEE30, MSK, SIK, SIK-1, SIK1B, SNF1LK
Links

HGNC:11142

NCBI Gene ID: 150094

neXtProt AC: NX_P57059

UniProt: P57059
Chr Location

21q22.3; chr21:43414483-43427131 (-) GRCh38

MGI Vertebrate Homology

Sik1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SIK1
Protein SuperFamily

Ser/Thr_PK_SNF1-like
Gene Tree

Sik1

Diseases

1 with human SIK1 associations

				Human Disease	Mouse Models
				developmental and epileptic encephalopathy 30 IDs developmental and epileptic encephalopathy 30 DOID:0080465 OMIM:616341

Click on a disease name to see all genes associated with that disease.

References

2 with disease annotations

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Phenotype Summary

21 phenotypes from 3 alleles in 4 genetic backgrounds
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Endonuclease-mediated

6
Gene trapped

7
Targeted

10
Genomic Mutations

2 involving Sik1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele and fed a high fat diet exhibit increased insulin sensitivity.

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All GO Annotations

68
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1292
Tissues

231
cDNA Data

23
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SIK1

Xenbase sik1

ZFIN sik1

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All Sequences

41
RefSeq

6
UniProt

3
CCDS

CCDS37552.1

Ensembl

ENSMUSG00000024042 (Evidence)
NCBI Gene

17691

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024042	Ensembl Gene Model \| MGI Sequence Detail	11555	C57BL/6J	± kb
transcript	ENSMUST00000024839	Ensembl \| MGI Sequence Detail	4521	Not Applicable
polypeptide	ENSMUSP00000024839	Ensembl \| MGI Sequence Detail	779	Not Applicable

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UniProt

3 Sequences
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR034672 Salt-Inducible kinase, catalytic domain

IPR008271 Serine/threonine-protein kinase, active site

IPR017090 Serine/threonine-protein kinase, SIK1/2

IPR015940 Ubiquitin-associated domain

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All nucleic 25

cDNA 24

Primer pair 1

Microarray probesets 3

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MGD-MRK-28045

Summaries

All 107

Developmental Gene Expression 10

Diseases 2

Gene Ontology 19

Phenotypes 54
Earliest

J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
Latest

J:357279 Donovan MG, et al., Multimodal analysis of dysregulated heme metabolism, hypoxic signaling, and stress erythropoiesis in Down syndrome. Cell Rep. 2024 Aug 27;43(8):114599

TSS for Sik1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr147333	Chr17:32075565-32075587 (-)	-798 bp
Tssr147332	Chr17:32074803-32074812 (-)	-30 bp
Tssr147331	Chr17:32074788-32074801 (-)	-17 bp
Tssr147330	Chr17:32074756-32074776 (-)	12 bp
Tssr147329	Chr17:32074734-32074748 (-)	37 bp
Tssr147328	Chr17:32069028-32069048 (-)	5,740 bp
Tssr147327	Chr17:32068978-32068991 (-)	5,793 bp
Tssr147326	Chr17:32068545-32068571 (-)	6,220 bp
Tssr147325	Chr17:32067806-32067821 (-)	6,964 bp
Tssr147324	Chr17:32063484-32063489 (-)	11,291 bp
Tssr147323	Chr17:32063347-32063352 (-)	11,428 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24