Ephb4 MGI Mouse Gene Detail - MGI:104757

Symbol

Ephb4
Name

Eph receptor B4
Synonyms

b2b2412Clo, Htk, MDK2, Myk1, Tyro11

Feature Type

protein coding gene
IDs

MGI:104757
NCBI Gene: 13846
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr5:137348371-137372784 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 76.38 cM
Mapping Data

2 experiments

SNPs within 2kb

798 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104757	protein coding gene	Chr5:137348371-137376931 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030225	protein coding gene	Chr5:142087355-142119516 (+)
A/J	MGP_AJ_G0030193	protein coding gene	Chr5:135907084-135936687 (+)
AKR/J	MGP_AKRJ_G0030126	protein coding gene	Chr5:140311834-140342196 (+)
BALB/cJ	MGP_BALBcJ_G0030203	protein coding gene	Chr5:137274039-137304571 (+)
C3H/HeJ	MGP_C3HHeJ_G0029919	protein coding gene	Chr5:140963198-140993764 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030655	protein coding gene	Chr5:147355024-147387763 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027873	protein coding gene	Chr5:130156288-130183798 (+)
CAST/EiJ	MGP_CASTEiJ_G0029329	protein coding gene	Chr5:140363901-140398314 (+)
CBA/J	MGP_CBAJ_G0029889	protein coding gene	Chr5:153194691-153223392 (+)
DBA/2J	MGP_DBA2J_G0030040	protein coding gene	Chr5:135810529-135839528 (+)
FVB/NJ	MGP_FVBNJ_G0029995	protein coding gene	Chr5:135003373-135035377 (+)
LP/J	MGP_LPJ_G0030129	protein coding gene	Chr5:142554668-142585118 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030027	protein coding gene	Chr5:156035869-156065324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030696	protein coding gene	Chr5:140165524-140195755 (+)
PWK/PhJ	MGP_PWKPhJ_G0029042	protein coding gene	Chr5:134889756-134919994 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028878	protein coding gene	Chr5:137725784-137763868 (+)
WSB/EiJ	MGP_WSBEiJ_G0029402	protein coding gene	Chr5:140897354-140927393 (+)

Human Ortholog

EPHB4, EPH receptor B4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHB4, EPH receptor B4
Synonyms

CMAVM2, HFASD, HTK, LMPHM7, MYK1, TYRO11
Links

HGNC:3395

NCBI Gene ID: 2050

neXtProt AC: NX_P54760

UniProt: P54760
Chr Location

7q22.1; chr7:100802565-100827523 (-) GRCh38

MGI Vertebrate Homology

Ephb4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: EPHB4
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Ephb4

Diseases

1 with Ephb4 mouse models; 1 with human EPHB4 associations

Human Disease

Mouse Models

cystic kidney disease

IDs

View 1 model

central conducting lymphatic anomaly

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

21 phenotypes from 3 alleles in 3 genetic backgrounds
10 images
42 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (ENU)

1
Endonuclease-mediated

8
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit arrested angiogenesis and heart development and midgestational lethality.

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All GO Annotations

58
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

976
Tissues

179
cDNA Data

77
Literature Summary

111

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ephb4

ZFIN ephb4a, ephb4b

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All Sequences

55
RefSeq

4
UniProt

7
CCDS

CCDS19767.1, CCDS51671.1

Ensembl

ENSMUSG00000029710 (Evidence)
NCBI Gene

13846

			Length	Strain/Species	Flank
genomic	13846	NCBI Gene Model \| MGI Sequence Detail	24414	C57BL/6J	± kb
transcript	NM_001159571	RefSeq \| MGI Sequence Detail	4361	C57BL/6
polypeptide	P54761	UniProt \| EBI \| MGI Sequence Detail	987	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000007132 ephrin type-B receptor 4

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR037636 EPH-B4, SAM domain

IPR001090 Ephrin receptor ligand binding domain

IPR027936 Ephrin receptor, transmembrane domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR034290 Ephrin type-B receptor 4, ligand binding domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050122 Receptor Tyrosine Kinase

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

P54761 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 85

cDNA 77

Primer pair 8

Microarray probesets 3

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MGD-MRK-28048, MGI:2140802, MGI:5614902

Summaries

All 188

Developmental Gene Expression 111

Diseases 1

Gene Ontology 11

Phenotypes 42
Earliest

J:17851 Andres AC, et al., Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis [published erratum appears in Oncogene 1994 Aug;9(8):2431]. Oncogene. 1994 May;9(5):1461-7
Latest

J:345473 Lee JG, et al., PIBF1 regulates trophoblast syncytialization and promotes cardiovascular development. Nat Commun. 2024 Feb 19;15(1):1487

TSS for Ephb4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49330	Chr5:137348363-137348379 (+)	0 bp
Tssr49331	Chr5:137348392-137348408 (+)	29 bp
Tssr49332	Chr5:137348424-137348439 (+)	61 bp
Tssr49333	Chr5:137348458-137348467 (+)	92 bp
Tssr49334	Chr5:137348633-137348741 (+)	316 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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