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Ephb3 Gene Detail
Summary
  • Symbol
    Ephb3
  • Name
    Eph receptor B3
  • Synonyms
    Cek10, Etk2, HEK2, MDK5, Sek4, Tyro6
  • Feature Type
    protein coding gene
  • IDs
    MGI:104770
    NCBI Gene: 13845
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21023530-21042054 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.62 cM, cytoband B1-B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104770
 protein coding gene Chr16:21023505-21042055 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022658
 protein coding gene Chr16:18621141-18639681 (+)
A/J MGP_AJ_G0022620
 protein coding gene Chr16:17730004-17748550 (+)
AKR/J MGP_AKRJ_G0022595
 protein coding gene Chr16:18473545-18492103 (+)
BALB/cJ MGP_BALBcJ_G0022624
 protein coding gene Chr16:17908932-17927472 (+)
C3H/HeJ MGP_C3HHeJ_G0022389
 protein coding gene Chr16:18583825-18602444 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023075
 protein coding gene Chr16:18990621-19009171 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020593
 protein coding gene Chr16:18437039-18455629 (+)
CAST/EiJ MGP_CASTEiJ_G0021919
 protein coding gene Chr16:18555728-18577738 (+)
CBA/J MGP_CBAJ_G0022361
 protein coding gene Chr16:19816947-19835505 (+)
DBA/2J MGP_DBA2J_G0022493
 protein coding gene Chr16:17718852-17738450 (+)
FVB/NJ MGP_FVBNJ_G0022468
 protein coding gene Chr16:17690208-17708714 (+)
LP/J MGP_LPJ_G0022560
 protein coding gene Chr16:18365231-18383786 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022488
 protein coding gene Chr16:19423889-19442431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023086
 protein coding gene Chr16:18406382-18424930 (+)
PWK/PhJ MGP_PWKPhJ_G0021659
 protein coding gene Chr16:17927460-17946806 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021489
 protein coding gene Chr16:18198312-18216833 (+)
WSB/EiJ MGP_WSBEiJ_G0021962
 protein coding gene Chr16:18373082-18391678 (+)



Homology
more
  • Human Ortholog
    EPHB3, EPH receptor B3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB3, EPH receptor B3
  • Synonyms
    EK2, ETK2, HEK2, TYRO6
  • Links
    NCBI Gene ID: 2049
    neXtProt AC: NX_P54753
    UniProt: P54753

  • Chr Location
    3q27.1; chr3:184561785-184582408 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    30 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects in corpus callosum formation and impaired Paneth cell downward migration in the intestinal epithelium, resulting in scattered positioning along crypt and villus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    72
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    983
  • Tissues
    178
  • cDNA Data
    61
  • Literature Summary
    81
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13845 NCBI Gene Model | MGI Sequence Detail 18525 C57BL/6J ±  kb
transcript NM_010143 RefSeq | MGI Sequence Detail 4160 C57BL/6  
polypeptide P54754 UniProt | EBI | MGI Sequence Detail 993 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007131 ephrin type-B receptor 3
    (term hierarchy)
  • EC
    2.7.10.1
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR050449 Ephrin receptor tyrosine kinases
    IPR034245 Ephrin type-B receptor 3, ligand binding domain
    IPR003961 Fibronectin type III
    IPR036116 Fibronectin type III superfamily
    IPR008979 Galactose-binding-like domain superfamily
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
  • GlyGen
    P54754 2 sites
Molecular
Reagents
less
  • All nucleic 76
    cDNA 63
    Primer pair 9
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-28061, MGI:2146639
References
more
  • Summaries
    All 168
    Developmental Gene Expression 81
    Gene Ontology 18
    Phenotypes 64
  • Earliest
    J:19646 Becker N, et al., Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. Mech Dev. 1994 Jul;47(1):3-17
  • Latest
    J:350995 Thowfeequ S, et al., An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration. Dev Cell. 2024 Jun 2;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory