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Erbb4 Gene Detail
Summary
  • Symbol
    Erbb4
  • Name
    erb-b2 receptor tyrosine kinase 4
  • Synonyms
    ErbB4, Her4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104771
    NCBI Gene: 13869
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:68071345-69147218 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    12347 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104771
 protein coding gene Chr1:68071063-69147756 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016120
 protein coding gene Chr1:68315362-69456673 (-)
A/J MGP_AJ_G0016103
 protein coding gene Chr1:65948607-67006470 (-)
AKR/J MGP_AKRJ_G0016060
 protein coding gene Chr1:67844937-68935355 (-)
BALB/cJ MGP_BALBcJ_G0016058
 protein coding gene Chr1:66031751-67109853 (-)
C3H/HeJ MGP_C3HHeJ_G0015889
 protein coding gene Chr1:68116192-69262364 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016511
 protein coding gene Chr1:70936626-72120913 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014232
 protein coding gene Chr1:61770927-62790474 (-)
CAST/EiJ MGP_CASTEiJ_G0015473
 protein coding gene Chr1:67305987-68452786 (-)
CBA/J MGP_CBAJ_G0015862
 protein coding gene Chr1:73302631-74540160 (-)
DBA/2J MGP_DBA2J_G0015963
 protein coding gene Chr1:65347225-66401878 (-)
FVB/NJ MGP_FVBNJ_G0015966
 protein coding gene Chr1:64552587-65602346 (-)
LP/J MGP_LPJ_G0016035
 protein coding gene Chr1:69371660-70513178 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015986
 protein coding gene Chr1:76372095-77900864 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016558
 protein coding gene Chr1:67775308-68881345 (-)
PWK/PhJ MGP_PWKPhJ_G0015260
 protein coding gene Chr1:64694510-65788428 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015039
 protein coding gene Chr1:67198094-68276678 (-)
WSB/EiJ MGP_WSBEiJ_G0015535
 protein coding gene Chr1:67539368-68670733 (-)



Homology
more
  • Human Ortholog
    ERBB4, erb-b2 receptor tyrosine kinase 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERBB4, erb-b2 receptor tyrosine kinase 4
  • Synonyms
    ALS19, HER4, p180erbB4
  • Links
    NCBI Gene ID: 2066
    neXtProt AC: NX_Q15303
    UniProt: Q15303

  • Chr Location
    2q34; chr2:211375717-212538841 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ERBB4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    140 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit cardiac defects, alterations in hindbrain development, and midgestational lethality. Heterozygotes show schizophrenia-like behavior. Genetically rescued females show mammary defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    153
  • GO References
    41
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1196
  • Tissues
    209
  • cDNA Data
    19
  • Literature Summary
    115
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000062209 Ensembl Gene Model | MGI Sequence Detail 1075874 C57BL/6J ±  kb
    transcript ENSMUST00000119142 Ensembl | MGI Sequence Detail 11782 Not Applicable  
    polypeptide ENSMUSP00000112713 Ensembl | MGI Sequence Detail 1308 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007160 receptor tyrosine-protein kinase erbB-4
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR049328 Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
      IPR006211 Furin-like cysteine-rich domain
      IPR006212 Furin-like repeat
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR032778 Growth factor receptor domain 4
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR000494 Receptor L-domain
      IPR036941 Receptor L-domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
    • GlyGen
      Q61527 11 sites, 5 N-linked glycans (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 21
      Primer pair 9
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28062
    References
    more
    • Summaries
      All 325
      Developmental Gene Expression 115
      Gene Ontology 41
      Phenotypes 140
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:353356 da Cunha Menezes E, et al., Effects of gestational hypothyroidism on mouse brain development: Gabaergic systems and oxidative stress. Dev Biol. 2024 Nov;515:112-120
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory