Bw1 QTL Detail

Summary

• Symbol
  Bw1
• Name
  body weight QTL 1

• Feature Type
  QTL
• IDs
  MGI:104777
  NCBI Gene: 109374
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  ChrX:20606783-47179225 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype reference
  

• All Mutations and Alleles
  3
• QTL
  3
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  109374

Other
Accession IDs

MGD-MRK-28069

References

• Summaries
  All 4

  Phenotypes 1
• Earliest
  J:29849 Dragani TA, et al., Mapping of body weight loci on mouse chromosome X. Mamm Genome. 1995 Nov;6(11):778-81
• Latest
  J:99477 Brown AC, et al., Searching QTL by gene expression: analysis of diabesity. BMC Genet. 2005 Mar 10;6(1):12

Candidate Genes for Bw1:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Rab9	ChrX:165240249-165262863 (-)	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for QTLs Bw1 (18 cM) and Bw3 (32 cM) on mouse Chromosome X as identified by ExQuest are Rgn and Rab9, respectively.
Rgn	ChrX:20416026-20428328 (+)	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for QTLs Bw1 (18 cM) and Bw3 (32 cM) on mouse Chromosome X as identified by ExQuest are Rgn and Rab9, respectively.