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Plcb3 Gene Detail
Summary
  • Symbol
    Plcb3
  • Name
    phospholipase C, beta 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:104778
    NCBI Gene: 18797
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6931081-6951738 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.10 cM, cytoband B
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    416 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104778
 protein coding gene Chr19:6929693-6953838 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024775
 protein coding gene Chr19:4046717-4063601 (-)
A/J MGP_AJ_G0024741
 protein coding gene Chr19:3716011-3731984 (-)
AKR/J MGP_AKRJ_G0024714
 protein coding gene Chr19:3836305-3852649 (-)
BALB/cJ MGP_BALBcJ_G0024741
 protein coding gene Chr19:3825407-3841452 (-)
C3H/HeJ MGP_C3HHeJ_G0024509
 protein coding gene Chr19:3960591-3977934 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025187
 protein coding gene Chr19:4139113-4155064 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022621
 protein coding gene Chr19:3622703-3638803 (-)
CAST/EiJ MGP_CASTEiJ_G0023981
 protein coding gene Chr19:3867755-3883781 (-)
CBA/J MGP_CBAJ_G0024481
 protein coding gene Chr19:4188669-4206837 (-)
DBA/2J MGP_DBA2J_G0024608
 protein coding gene Chr19:3688414-3704443 (-)
FVB/NJ MGP_FVBNJ_G0024574
 protein coding gene Chr19:3718173-3734942 (-)
LP/J MGP_LPJ_G0024694
 protein coding gene Chr19:3907154-3926072 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024603
 protein coding gene Chr19:4096327-4115049 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025235
 protein coding gene Chr19:3968146-3985497 (-)
PWK/PhJ MGP_PWKPhJ_G0023727
 protein coding gene Chr19:3732056-3748310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023532
 protein coding gene Chr19:3791313-3808413 (-)
WSB/EiJ MGP_WSBEiJ_G0024043
 protein coding gene Chr19:3872029-3889980 (-)



Homology
more
  • Human Ortholog
    PLCB3, phospholipase C beta 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLCB3, phospholipase C beta 3
  • Synonyms
    SMDCD
  • Links
    NCBI Gene ID: 5331
    neXtProt AC: NX_Q01970
    UniProt: Q01970

  • Chr Location
    11q13.1; chr11:64251530-64269452 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLCB3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one targeted mutation die at E2.5 and exhibit poor embryonic organization and hypocellularity. Mice homozygous for a second targeted mutation survive to adulthood and exhibit an increased antinocieptive response to opioids.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    116
  • cDNA Data
    63
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18797 NCBI Gene Model | MGI Sequence Detail 20658 C57BL/6J ±  kb
    transcript NM_008874 RefSeq | MGI Sequence Detail 4273 ZRU/MplStud  
    polypeptide P51432 UniProt | EBI | MGI Sequence Detail 1234 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012830 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
      (term hierarchy)
    • EC
      3.1.4.11
    • InterPro Domains
      IPR000008 C2 domain
      IPR035892 C2 domain superfamily
      IPR011992 EF-hand domain pair
      IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
      IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
      IPR001192 Phosphoinositide phospholipase C family
      IPR014815 Phospholipase C-beta, C-terminal domain
      IPR042531 Phospholipase C-beta, C-terminal domain superfamily
      IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
      IPR037862 PLC-beta, PH domain
      IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
    • GlyGen
      P51432 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 1
      cDNA 64
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-28070
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 6
      Gene Ontology 14
      Phenotypes 28
    • Earliest
      J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
    • Latest
      J:350715 Ascencio Gutierrez V, et al., TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose. Chem Senses. 2024 Jan 1;49
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory