Skts2 QTL Detail

Summary

• Symbol
  Skts2
• Name
  skin tumor susceptibility 2

• Feature Type
  QTL
• IDs
  MGI:104787
  NCBI Gene: 112153
• Candidate Genes
  2 Genes

Location &
Maps

• Sequence Map
  Chr7:129922733-129922943 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 7, 73.19 cM (cM position of peak correlated region/marker)
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  112153

Other
Accession IDs

MGD-MRK-28079

References

• Summaries
  All 4

  Phenotypes 2
• Earliest
  J:27733 Nagase H, et al., Distinct genetic loci control development of benign and malignant skin tumours in mice. Nat Genet. 1995 Aug;10(4):424-9
• Latest
  J:85134 Nagase H, et al., Allele-specific Hras mutations and genetic alterations at tumor susceptibility loci in skin carcinomas from interspecific hybrid mice. Cancer Res. 2003 Aug 15;63(16):4849-53

Candidate Genes for Skts2:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Hras	Chr7:140770839-140773938 (-)	J:85134	Several skin tumor susceptibility QTLs (Skts1-Skts13) were previously identified in a population of (NIH/Ola x M. spretus)F1 x NIH/Ola backcross animals. In this study the association of allele-specific mutations at the Skts intervals was examined in skin carcinoma samples. Several loci displayed allelic loss or duplication in skin carcinomas. 90 % of papillomas and carcinomas contain a mutation at codon 61 of the Hras1 gene (72 cM). In 23 out of 26 mouse tumors the Hras1 mutation occurred in the NIH/Ola-inherited allele. Hras1 maps near skin tumor susceptibility QTL Skts2 (64 cM on mouse Chromosome 7). A nearby marker, D7Mit12 (66 cM) also shows allelic imbalance involving the NIH/Ola allele. On mouse Chromosome 6, preferential gain of the M. spretus allele or loss of the NIH/Ola allele was observed at D6Mit9 (36.5 cM) near Skts11 in 21 out of 21 carcinomas, and preferential gain of the M. spretus allele was observed at D6Mit15 (74 cM) near Skts12 in 14 out of 16 carcinomas. On mouse Chromosome 9, preferential loss of the M. spretus allele or gain of the NIH/Ola allele was observed at D9Mit9 (48 cM) near Skts6 in 16 out of 23 carcinomas. On mouse Chromosome 16, preferential loss of the M. spretus allele or gain of the NIH/Ola allele was observed at D16Mit2 (14.1 cM) near Skts9 in 10 out of 29 carcinomas.
Tyr	Chr7:87073979-87142637 (-)	J:65010	Segregation analysis of a (Car-R x Car-S)F2 intercross revealed association of coat color with skin tumor susceptibility. Phenotypically selected inbred lines Car-R and Car-S are derived from progenitor strains A/J, DBA/2J, P/J, CBA/J, SJL/J, BALB/cJ, SWR/J, and C57BR/6J. Animals resistant or susceptible to skin tumors after challenge with carcinogens were selected as progenitors for each successive generation in the Car-R and Car-S lines, respectively. By the eighth generation of inbreeding all Car-S mice had white coats and all Car-R mice had coats of various colors. Authors estimate 7-10 QTLs affect skin tumor susceptibility. A region on mouse chromosome 7 containing the albino locus, Tyr, and a skin tumor susceptibility QTL, Skts2, may be a candidatelocus.