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Siae Gene Detail
Summary
  • Symbol
    Siae
  • Name
    sialic acid acetylesterase
  • Synonyms
    clone 165, LSE, Ysg2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104803
    NCBI Gene: 22619
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:37525117-37559554 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 20.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1015 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104803
 protein coding gene Chr9:37466994-37560951 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034570
 protein coding gene Chr9:35615769-35651915 (+)
A/J MGP_AJ_G0034549
 protein coding gene Chr9:34659987-34695398 (+)
AKR/J MGP_AKRJ_G0034476
 protein coding gene Chr9:35419210-35456330 (+)
BALB/cJ MGP_BALBcJ_G0034540
 protein coding gene Chr9:34496469-34531213 (+)
C3H/HeJ MGP_C3HHeJ_G0034253
 protein coding gene Chr9:35852290-35891566 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035062
 protein coding gene Chr9:36750192-36787119 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031988
 protein coding gene Chr9:33762463-33797823 (+)
CAST/EiJ MGP_CASTEiJ_G0033574
 protein coding gene Chr9:35549688-35585407 (+)
CBA/J MGP_CBAJ_G0034226
 protein coding gene Chr9:38015889-38053994 (+)
DBA/2J MGP_DBA2J_G0034384
 protein coding gene Chr9:34706769-34741585 (+)
FVB/NJ MGP_FVBNJ_G0034325
 protein coding gene Chr9:33962949-33997896 (+)
LP/J MGP_LPJ_G0034469
 protein coding gene Chr9:35792398-35827065 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034371
 protein coding gene Chr9:39631266-39665494 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035081
 protein coding gene Chr9:35358512-35393869 (+)
PWK/PhJ MGP_PWKPhJ_G0033280
 protein coding gene Chr9:34603405-34638323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033114
 protein coding gene Chr9:35555156-35595899 (+)
WSB/EiJ MGP_WSBEiJ_G0033690
 protein coding gene Chr9:35175336-35210376 (+)



Homology
more
  • Human Ortholog
    SIAE, sialic acid acetylesterase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIAE, sialic acid acetylesterase
  • Synonyms
    AIS6, CSE-C, CSEC, LSE, YSG2
  • Links
    NCBI Gene ID: 54414
    neXtProt AC: NX_Q9HAT2
    UniProt: Q9HAT2

  • Chr Location
    11q24.2; chr11:124633113-124695707 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SIAE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    1 images
    6 phenotype references
Mice homozygous for a null allele exhibit normal marginal zone B cell and memory phenotype T cell numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    122
  • cDNA Data
    20
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22619 NCBI Gene Model | MGI Sequence Detail 34438 C57BL/6J ±  kb
transcript NM_011734 RefSeq | MGI Sequence Detail 3399 ZRU/MplStud  
polypeptide P70665 UniProt | EBI | MGI Sequence Detail 541 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 21
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-28096
References
more
  • Summaries
    All 36
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:37624 Butor C, et al., Structural, immunological, and biosynthetic studies of a sialic acid-specific O-acetylesterase from rat liver. J Biol Chem. 1993 May 15;268(14):10207-13
  • Latest
    J:261411 Danyukova T, et al., Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Hum Mol Genet. 2018 May 15;27(10):1711-1722
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory