About   Help   FAQ
Nkx1-2 Gene Detail
Summary
  • Symbol
    Nkx1-2
  • Name
    NK1 homeobox 2
  • Synonyms
    Nkx-1.1, Nkx-1.2, Sax1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104806
    NCBI Gene: 20231
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:132197968-132201366 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 76.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104806
 protein coding gene Chr7:132196607-132201366 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033113
 protein coding gene Chr7:137294771-137299530 (-)
A/J MGP_AJ_G0033095
 protein coding gene Chr7:133514659-133519418 (-)
AKR/J MGP_AKRJ_G0033027
 protein coding gene Chr7:137076760-137081648 (-)
BALB/cJ MGP_BALBcJ_G0033096
 protein coding gene Chr7:133196626-133201385 (-)
C3H/HeJ MGP_C3HHeJ_G0032810
 protein coding gene Chr7:136908275-136913034 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033607
 protein coding gene Chr7:142529530-142534289 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030578
 protein coding gene Chr7:134793927-134798507 (-)
CAST/EiJ MGP_CASTEiJ_G0032140
 protein coding gene Chr7:128808990-128813686 (-)
CBA/J MGP_CBAJ_G0032783
 protein coding gene Chr7:147355362-147360121 (-)
DBA/2J MGP_DBA2J_G0032935
 protein coding gene Chr7:131526431-131531190 (-)
FVB/NJ MGP_FVBNJ_G0032888
 protein coding gene Chr7:131351170-131355929 (-)
LP/J MGP_LPJ_G0033029
 protein coding gene Chr7:138800434-138805206 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032920
 protein coding gene Chr7:148283926-148288685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033627
 protein coding gene Chr7:136056166-136060925 (-)
PWK/PhJ MGP_PWKPhJ_G0031846
 protein coding gene Chr7:124548148-124552931 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031692
 protein coding gene Chr7:122850724-122855442 (-)
WSB/EiJ MGP_WSBEiJ_G0032251
 protein coding gene Chr7:136963703-136968448 (-)



Homology
more
  • Human Ortholog
    NKX1-2, NK1 homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX1-2, NK1 homeobox 2
  • Synonyms
    bB238F13.2, C10orf121, NKX-1.1
  • Links
    NCBI Gene ID: 390010
    neXtProt AC: NX_Q9UD57
    UniProt: Q9UD57

  • Chr Location
    10q26.13
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1022
  • Tissues
    179
  • cDNA Data
    13
  • Literature Summary
    27
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20231 NCBI Gene Model | MGI Sequence Detail 3399 C57BL/6J ±  kb
transcript NM_009123 RefSeq | MGI Sequence Detail 1903 Not Specified  
polypeptide P42580 UniProt | EBI | MGI Sequence Detail 305 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 2
    cDNA 13
    Primer pair 3
    Other 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-28100
References
more
  • Summaries
    All 59
    Developmental Gene Expression 27
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:26182 Schubert FR, et al., Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev. 1995 May;51(1):99-114
  • Latest
    J:348701 Nakagawa S, et al., The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development. Stem Cell Reports. 2024 May 14;19(5):689-709
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory