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Ier2 Gene Detail
Summary
  • Symbol
    Ier2
  • Name
    immediate early response 2
  • Synonyms
    ch1, pip92
  • Feature Type
    protein coding gene
  • IDs
    MGI:104815
    NCBI Gene: 15936
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85387960-85389481 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104815
 protein coding gene Chr8:85387960-85389483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033864
 protein coding gene Chr8:85568762-85570281 (-)
A/J MGP_AJ_G0033847
 protein coding gene Chr8:82202642-82204161 (-)
AKR/J MGP_AKRJ_G0033773
 protein coding gene Chr8:84635320-84636839 (-)
BALB/cJ MGP_BALBcJ_G0033840
 protein coding gene Chr8:82323533-82325052 (-)
C3H/HeJ MGP_C3HHeJ_G0033550
 protein coding gene Chr8:85252887-85254406 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034360
 protein coding gene Chr8:88855110-88856631 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031302
 protein coding gene Chr8:75996762-75998273 (-)
CAST/EiJ MGP_CASTEiJ_G0032880
 protein coding gene Chr8:84674884-84676406 (-)
CBA/J MGP_CBAJ_G0033526
 protein coding gene Chr8:91904364-91905883 (-)
DBA/2J MGP_DBA2J_G0033680
 protein coding gene Chr8:81841910-81843429 (-)
FVB/NJ MGP_FVBNJ_G0033627
 protein coding gene Chr8:80779263-80780782 (-)
LP/J MGP_LPJ_G0033771
 protein coding gene Chr8:85682950-85684469 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033669
 protein coding gene Chr8:94445214-94446732 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034377
 protein coding gene Chr8:84623956-84625477 (-)
PWK/PhJ MGP_PWKPhJ_G0032584
 protein coding gene Chr8:81076807-81078328 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032420
 protein coding gene Chr8:83436206-83437714 (-)
WSB/EiJ MGP_WSBEiJ_G0032993
 protein coding gene Chr8:85047970-85049489 (-)



Homology
more
  • Human Ortholog
    IER2, immediate early response 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IER2, immediate early response 2
  • Synonyms
    CHX1, ETR101
  • Links
    NCBI Gene ID: 9592
    neXtProt AC: NX_Q9BTL4
    UniProt: Q9BTL4

  • Chr Location
    19p13.13; chr19:13150411-13154911 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human IER2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Radiation induced
    1
  • Genomic Mutations
    2 involving Ier2
  • Find Mice (IMSR)
    10 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    16
  • cDNA Data
    157
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15936 NCBI Gene Model | MGI Sequence Detail 1522 C57BL/6J ±  kb
transcript NM_010499 RefSeq | MGI Sequence Detail 1541 ZRU/MplStud  
polypeptide P17950 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 160
    Genomic 1
    cDNA 157
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-28109, MGI:2142503
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 5
    Phenotypes 35
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory