Hnrnpl MGI Mouse Gene Detail - MGI:104816 - heterogeneous nuclear ribonucleoprotein L

Symbol

Hnrnpl
Name

heterogeneous nuclear ribonucleoprotein L
Synonyms

D830027H13Rik, Hnrpl

Feature Type

protein coding gene
IDs

MGI:104816
NCBI Gene: 15388
Alliance

gene page
Transcription Start Sites

24 TSS

Sequence Map

Chr7:28507971-28521693 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 16.93 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

306 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104816	protein coding gene	Chr7:28507966-28521693 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031962	protein coding gene	Chr7:27653414-27666927 (+)
A/J	MGP_AJ_G0031940	protein coding gene	Chr7:26958031-26971749 (+)
AKR/J	MGP_AKRJ_G0031872	protein coding gene	Chr7:27651000-27664754 (+)
BALB/cJ	MGP_BALBcJ_G0031947	protein coding gene	Chr7:27115540-27129339 (+)
C3H/HeJ	MGP_C3HHeJ_G0031666	protein coding gene	Chr7:28026238-28040990 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032411	protein coding gene	Chr7:28555795-28571210 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029463	protein coding gene	Chr7:28019115-28032888 (+)
CAST/EiJ	MGP_CASTEiJ_G0031001	protein coding gene	Chr7:21348684-21362138 (+)
CBA/J	MGP_CBAJ_G0031632	protein coding gene	Chr7:29831474-29846443 (+)
DBA/2J	MGP_DBA2J_G0031784	protein coding gene	Chr7:26709486-26723248 (+)
FVB/NJ	MGP_FVBNJ_G0031741	protein coding gene	Chr7:26793317-26807209 (+)
LP/J	MGP_LPJ_G0031864	protein coding gene	Chr7:27980241-27993934 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031777	protein coding gene	Chr7:29298415-29312047 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032441	protein coding gene	Chr7:27132901-27146538 (+)
PWK/PhJ	MGP_PWKPhJ_G0030726	protein coding gene	Chr7:21734349-21747926 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030559	protein coding gene	Chr7:18155186-18168465 (+)
WSB/EiJ	MGP_WSBEiJ_G0031110	protein coding gene	Chr7:27500698-27514392 (+)

Human Ortholog

HNRNPL, heterogeneous nuclear ribonucleoprotein L

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPL, heterogeneous nuclear ribonucleoprotein L
Synonyms

hnRNP-L, HNRPL, P/OKcl.14
Links

HGNC:5045

NCBI Gene ID: 3191

neXtProt AC: NX_P14866

UniProt: P14866
Chr Location

19q13.2; chr19:38836370-38852347 (-) GRCh38

MGI Vertebrate Homology

Hnrnpl stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: HNRNPL
Gene Tree

Hnrnpl

Diseases

3 with human HNRNPL associations

				Human Disease	Mouse Models
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				lung cancer IDs lung cancer DOID:1324 DOID:13075 DOID:1322 DOID:9881 ICD10CM:C34.1 ICD10CM:C34.2 ICD10CM:C34.3 ICD9CM:162.3 ICD9CM:162.4 ICD9CM:162.5 ICD9CM:162.8 OMIM:211980 OMIM:608935 OMIM:612571 OMIM:612593 OMIM:614210 UMLS_CUI:C0024624 UMLS_CUI:C0153491 UMLS_CUI:C0153492 UMLS_CUI:C0153493
				systemic scleroderma IDs systemic scleroderma DOID:418 EFO:0000717 ICD10CM:M34.0 ICD9CM_2006:710.1 ICD9CM:710.1 MESH:D012595 NCI:C72070 OMIM:181750 UMLS_CUI:C0036421

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

71
Endonuclease-mediated

1
Gene trapped

67
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted allele exhibit embryonic letahlity after E3.5. Mice homozygous for a conditional allele activated in thymocytes exhibit decreased T cells in the periphery associated with impaired thymocyte chemotaxis.

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All GO Annotations

32
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

63
cDNA Data

147
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnrnpl

ZFIN hnrnpl

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All Sequences

84
RefSeq

23
UniProt

8
CCDS

CCDS39864.2

Ensembl

ENSMUSG00000015165 (Evidence)
NCBI Gene

15388

			Length	Strain/Species	Flank
genomic	15388	NCBI Gene Model \| MGI Sequence Detail	13723	C57BL/6J	± kb
transcript	NR_175319	RefSeq \| MGI Sequence Detail	2725	C57BL/6
polypeptide	Q8R081	UniProt \| EBI \| MGI Sequence Detail	586	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000008670 heterogeneous nuclear ribonucleoprotein L

(term hierarchy)
PDB

3S01, 3TYT
InterPro Domains

IPR006536 HnRNP-L/PTB

IPR035005 hnRNP-L, RNA recognition motif 1

IPR035008 hnRNP-L, RNA recognition motif 2

IPR034816 hnRNP-L, RNA recognition motif 3

IPR034817 hnRNP-L, RNA recognition motif 4

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR021790 PTBP1-like, RNA recognition motif 2

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

Q8R081 1 site, 1 O-linked glycan (1 site)

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All nucleic 155

cDNA 147

Primer pair 8

Microarray probesets 3

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MGD-MRK-28110, MGI:2142336, MGI:2445140

Summaries

All 56

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 11
Earliest

J:23142 Ferreira J, et al., The biogenesis of the coiled body during early mouse development. Development. 1995 Feb;121(2):601-12
Latest

J:353724 Subramani PG, et al., Conserved role of hnRNPL in alternative splicing of epigenetic modifiers enables B cell activation. EMBO Rep. 2024 Jun;25(6):2662-2697

TSS for Hnrnpl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr65525	Chr7:28508220-28508257 (+)	268 bp
Tssr65526	Chr7:28508655-28508676 (+)	695 bp
Tssr65527	Chr7:28510311-28510343 (+)	2,356 bp
Tssr65528	Chr7:28510353-28510376 (+)	2,394 bp
Tssr2172	Chr7:28510389-28510397 (+)	2,422 bp
Tssr2173	Chr7:28510497-28510502 (+)	2,529 bp
Tssr65529	Chr7:28512700-28512719 (+)	4,739 bp
Tssr65530	Chr7:28513333-28513360 (+)	5,376 bp
Tssr65531	Chr7:28513416-28513427 (+)	5,451 bp
Tssr65532	Chr7:28513434-28513448 (+)	5,470 bp
Tssr65533	Chr7:28513450-28513468 (+)	5,488 bp
Tssr65534	Chr7:28514268-28514272 (+)	6,299 bp
Tssr65535	Chr7:28514567-28514582 (+)	6,604 bp
Tssr65536	Chr7:28517882-28517903 (+)	9,922 bp
Tssr65537	Chr7:28517965-28517976 (+)	10,000 bp
Tssr65538	Chr7:28518017-28518028 (+)	10,052 bp
Tssr65539	Chr7:28518105-28518130 (+)	10,147 bp
Tssr65540	Chr7:28518175-28518188 (+)	10,211 bp
Tssr65541	Chr7:28518204-28518232 (+)	10,247 bp
Tssr65542	Chr7:28520054-28520071 (+)	12,092 bp
Tssr65543	Chr7:28520077-28520138 (+)	12,137 bp
Tssr65544	Chr7:28521432-28521455 (+)	13,473 bp
Tssr65545	Chr7:28521458-28521469 (+)	13,493 bp
Tssr65546	Chr7:28521476-28521478 (+)	13,506 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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