Hnrnpa1 MGI Mouse Gene Detail - MGI:104820 - heterogeneous nuclear ribonucleoprotein A1

Symbol

Hnrnpa1
Name

heterogeneous nuclear ribonucleoprotein A1
Synonyms

D15Ertd119e, Hdp, hnrnp-A, Hnrpa1

Feature Type

protein coding gene
IDs

MGI:104820
NCBI Gene: 15382
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr15:103148859-103155119 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 58.58 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

134 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104820	protein coding gene	Chr15:103148840-103155119 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022435	protein coding gene	Chr15:105492609-105497212 (+)
A/J	MGP_AJ_G0022397	protein coding gene	Chr15:101322619-101326663 (+)
AKR/J	MGP_AKRJ_G0022372	protein coding gene	Chr15:104394714-104401020 (+)
BALB/cJ	MGP_BALBcJ_G0022401	protein coding gene	Chr15:101369189-101371099 (+)
C3H/HeJ	MGP_C3HHeJ_G0022168	protein coding gene	Chr15:104488907-104497626 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022850	protein coding gene	Chr15:109380121-109385930 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020373	protein coding gene	Chr15:97086024-97090606 (+)
CAST/EiJ	MGP_CASTEiJ_G0021694	protein coding gene	Chr15:105360818-105366547 (+)
CBA/J	MGP_CBAJ_G0022137	protein coding gene	Chr15:113231080-113235139 (+)
DBA/2J	MGP_DBA2J_G0022268	protein coding gene	Chr15:100595440-100601090 (+)
FVB/NJ	MGP_FVBNJ_G0022244	protein coding gene	Chr15:99659855-99665370 (+)
LP/J	MGP_LPJ_G0022337	protein coding gene	Chr15:105639907-105644608 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0022862	protein coding gene	Chr15:104438825-104443437 (+)
PWK/PhJ	MGP_PWKPhJ_G0021434	protein coding gene	Chr15:100776944-100781676 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021266	protein coding gene	Chr15:104274977-104282193 (+)
WSB/EiJ	MGP_WSBEiJ_G0021744	protein coding gene	Chr15:105056027-105062463 (+)

Human Ortholog

HNRNPA1, heterogeneous nuclear ribonucleoprotein A1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HNRNPA1, heterogeneous nuclear ribonucleoprotein A1
Synonyms

ALS19, ALS20, hnRNP A1, hnRNP-A1, HNRPA1, HNRPA1L3, IBMPFD3, MPD3, UP 1
Links

HGNC:5031

NCBI Gene ID: 3178

neXtProt AC: NX_P09651

UniProt: P09651
Chr Location

12q13.13; chr12:54280193-54287088 (+) GRCh38

Human Ortholog

HNRNPA1L2, heterogeneous nuclear ribonucleoprotein A1 like 2
Links

HGNC:27067

NCBI Gene ID: 144983

neXtProt AC: NX_Q32P51

UniProt: Q32P51
Chr Location

13q14.3; chr13:52617525-52643773 (+) GRCh38

MGI Vertebrate Homology

Hnrnpa1 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: HNRNPA1, HNRNPA1L2
Gene Tree

Hnrnpa1

Diseases

4 with human HNRNPA1 associations

				Human Disease	Mouse Models
				amyotrophic lateral sclerosis type 20 IDs amyotrophic lateral sclerosis type 20 DOID:0060211 OMIM:615426
				distal myopathy 3 IDs distal myopathy 3 DOID:0111189 OMIM:610099 ORDO:399086
				inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 IDs inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 3 DOID:0111386 OMIM:615424
				tropical spastic paraparesis IDs tropical spastic paraparesis DOID:321 ICD10CM:G04.1 MESH:D015493 NCI:C179058 OMIM:159580 UMLS_CUI:C0030481

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Endonuclease-mediated

2
Gene trapped

27
Targeted

3
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit prenatal and neonatal lethality, dilated cardiacmyopathy, and hypoplastic tongue and intercostal muscles. Mice heterozygous for a knock-out allele exhibit altered cardiac signaling, increased heart rate and increased systemic arterial systolic blood pressure.

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All GO Annotations

43
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

815
Tissues

46
cDNA Data

35
Literature Summary

16

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hnrnpa1

ZFIN hnrnpa1a, hnrnpa1b

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All Sequences

82
RefSeq

6
UniProt

6
CCDS

CCDS37232.1, CCDS37233.1

Ensembl

ENSMUSG00000046434 (Evidence)
NCBI Gene

15382

			Length	Strain/Species	Flank
genomic	ENSMUSG00000046434	Ensembl Gene Model \| MGI Sequence Detail	6261	C57BL/6J	± kb
transcript	ENSMUST00000230489	Ensembl \| MGI Sequence Detail	3118	Not Applicable
polypeptide	ENSMUSP00000154865	Ensembl \| MGI Sequence Detail	373	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008658 heterogeneous nuclear ribonucleoprotein A1

(term hierarchy)
InterPro Domains

IPR021662 Heterogeneous nuclear ribonucleoprotein A1/A2, C-terminal

IPR034516 hnRNP A1/3, RNA recognition motif 2

IPR034845 hnRNP A1, RNA recognition motif 1

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain
GlyGen

P49312 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 42

Genomic 2

cDNA 35

Primer pair 4

Other 1

Microarray probesets 8

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MGD-MRK-26049, MGD-MRK-28114, MGI:104612, MGI:1261777

Summaries

All 69

Developmental Gene Expression 16

Gene Ontology 10

Phenotypes 8
Earliest

J:1572 Varmuza S, et al., Isolation of epiblast-specific cDNA clones by differential hybridization with polymerase chain reaction-amplified probes derived from single embryos. Mol Reprod Dev. 1992 Aug;32(4):339-48
Latest

J:343308 Zhang Q, et al., hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA. Cell Rep. 2023 Nov 28;42(11):113401

TSS for Hnrnpa1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133517	Chr15:103148374-103148420 (+)	-462 bp
Tssr133518	Chr15:103148448-103148497 (+)	-386 bp
Tssr133519	Chr15:103148832-103148856 (+)	-15 bp
Tssr133520	Chr15:103148869-103148880 (+)	16 bp
Tssr133521	Chr15:103152430-103152446 (+)	3,579 bp
Tssr4744	Chr15:103154013-103154020 (+)	5,158 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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