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Cpox Gene Detail
Summary
  • Symbol
    Cpox
  • Name
    coproporphyrinogen oxidase
  • Synonyms
    cac, clone 560, Cpo, M100835, nct
  • Feature Type
    protein coding gene
  • IDs
    MGI:104841
    NCBI Gene: 12892
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:58490571-58500754 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16,
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104841
 protein coding gene Chr16:58490571-58537999 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022905
 protein coding gene Chr16:57846387-57860259 (+)
A/J MGP_AJ_G0022872
 protein coding gene Chr16:55380885-55393835 (+)
AKR/J MGP_AKRJ_G0022844
 protein coding gene Chr16:57104455-57115932 (+)
BALB/cJ MGP_BALBcJ_G0022872
 protein coding gene Chr16:55469050-55479206 (+)
C3H/HeJ MGP_C3HHeJ_G0022635
 protein coding gene Chr16:57324117-57336960 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023320
 protein coding gene Chr16:59461796-59474033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020831
 protein coding gene Chr16:54916823-54927033 (+)
CAST/EiJ MGP_CASTEiJ_G0022162
 protein coding gene Chr16:57662876-57674261 (+)
CBA/J MGP_CBAJ_G0022608
 protein coding gene Chr16:61838623-61851224 (+)
DBA/2J MGP_DBA2J_G0022740
 protein coding gene Chr16:55099914-55110086 (+)
FVB/NJ MGP_FVBNJ_G0022715
 protein coding gene Chr16:54862942-54873139 (+)
LP/J MGP_LPJ_G0022807
 protein coding gene Chr16:57642106-57655112 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022733
 protein coding gene Chr16:62211941-62226722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023335
 protein coding gene Chr16:57243188-57255018 (+)
PWK/PhJ MGP_PWKPhJ_G0021901
 protein coding gene Chr16:55406532-55416783 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021731
 protein coding gene Chr16:56997963-57015597 (+)
WSB/EiJ MGP_WSBEiJ_G0022206
 protein coding gene Chr16:57282930-57293218 (+)



Homology
more
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPOX, coproporphyrinogen oxidase
  • Synonyms
    COX, CPO, CPX, HARPO, HCP
  • Links
    NCBI Gene ID: 1371
    neXtProt AC: NX_P36551
    UniProt: P36551

  • Chr Location
    3q11.2; chr3:98570488-98593648 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Cpox mouse models; 2 with human CPOX associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous allele develop cataracts. Mice homozygous for an ENU-induced allele have reduced mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) and increased red blood cell volume distribution width (RDW).
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    807
  • Tissues
    98
  • cDNA Data
    58
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12892 NCBI Gene Model | MGI Sequence Detail 10184 C57BL/6J ±  kb
    transcript NM_007757 RefSeq | MGI Sequence Detail 3186 ZRU/MplStud  
    polypeptide P36552 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000005826 oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
      (term hierarchy)
    • EC
      1.3.3.3
    • InterPro Domains
      IPR001260 Coproporphyrinogen III oxidase, aerobic
      IPR018375 Coproporphyrinogen III oxidase, conserved site
      IPR036406 Oxygen-dependent coproporphyrinogen III oxidase superfamily
    • GlyGen
      P36552 2 sites, 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 2
      cDNA 59
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12796, MGD-MRK-28136, MGI:3807240, MGI:97287
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 5
      Diseases 2
      Gene Ontology 14
      Phenotypes 24
    • Earliest
      J:155095 Nakano K, et al., Hereditary Cataract in Mice. Jap J Clin Opthalmol. 1960;14:194-200
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory