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Zfp91 Gene Detail
Summary
  • Symbol
    Zfp91
  • Name
    zinc finger protein 91
  • Synonyms
    9130014I08Rik, A530054C17Rik, Pzf
  • Feature Type
    protein coding gene
  • IDs
    MGI:104854
    NCBI Gene: 109910
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:12744384-12773490 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.73 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    494 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104854
 protein coding gene Chr19:12744303-12773490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024913
 protein coding gene Chr19:10248471-10285188 (-)
A/J MGP_AJ_G0024889
 protein coding gene Chr19:9600090-9634420 (-)
AKR/J MGP_AKRJ_G0024861
 protein coding gene Chr19:10075258-10110959 (-)
BALB/cJ MGP_BALBcJ_G0024888
 protein coding gene Chr19:9610738-9645952 (-)
C3H/HeJ MGP_C3HHeJ_G0024652
 protein coding gene Chr19:9966066-10000580 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025337
 protein coding gene Chr19:10797767-10833752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022763
 protein coding gene Chr19:10232872-10268287 (-)
CAST/EiJ MGP_CASTEiJ_G0024121
 protein coding gene Chr19:9529468-9566095 (-)
CBA/J MGP_CBAJ_G0024626
 protein coding gene Chr19:10895525-10934575 (-)
DBA/2J MGP_DBA2J_G0024758
 protein coding gene Chr19:9659661-9694601 (-)
FVB/NJ MGP_FVBNJ_G0024721
 protein coding gene Chr19:9665307-9699703 (-)
LP/J MGP_LPJ_G0024841
 protein coding gene Chr19:10327336-10362138 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024748
 protein coding gene Chr19:10659285-10696504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025385
 protein coding gene Chr19:10059134-10095212 (-)
PWK/PhJ MGP_PWKPhJ_G0023870
 protein coding gene Chr19:9113052-9147931 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023674
 protein coding gene Chr19:9218477-9254449 (-)
WSB/EiJ MGP_WSBEiJ_G0024189
 protein coding gene Chr19:9915064-9950492 (-)



Homology
more
  • Human Ortholog
    ZFP91, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP91, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
  • Synonyms
    DMS-8, DSM-8, DSM8, FKSG11, PZF, ZFP-91, ZNF757
  • Links
    NCBI Gene ID: 80829
    neXtProt AC: NX_Q96JP5
    UniProt: Q96JP5

  • Chr Location
    11q12.1; chr11:58579063-58621550 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ZFP91 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
T regulatory cell-specific deleted mice exhibit attenuated activation of autophagy in T regs and impaired T reg cell homeostasis and function resulting in increased sensitivity to colonic inflammation and inflammation-driven colon carcinogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    56
  • cDNA Data
    27
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024695 Ensembl Gene Model | MGI Sequence Detail 29107 C57BL/6J ±  kb
    transcript ENSMUST00000038627 Ensembl | MGI Sequence Detail 5531 Not Applicable  
    polypeptide ENSMUSP00000037971 Ensembl | MGI Sequence Detail 572 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 1
      cDNA 31
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28151, MGI:1914817, MGI:2147630, MGI:2147742, MGI:2444795
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:23225 Saotome Y, et al., A widely expressed novel C2H2 zinc-finger protein with multiple consensus phosphorylation sites is conserved in mouse and man. Gene. 1995 Jan 23;152(2):233-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory