Ptcra MGI Mouse Gene Detail - MGI:104857 - pre T cell antigen receptor alpha

Symbol

Ptcra
Name

pre T cell antigen receptor alpha
Synonyms

pT[a], pT-alpha, pTalpha

Feature Type

protein coding gene
IDs

MGI:104857
NCBI Gene: 19208
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:47066589-47074638 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.90 cM, cytoband D-E1
Mapping Data

2 experiments

SNPs within 2kb

377 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104857	protein coding gene	Chr17:47066589-47074659 (-)
129S1/SvImJ	ENSMUSG00200025340	protein coding gene	Chr17:42264951-42273208 (-)
A/J	ENSMUSG00195017754	protein coding gene	Chr17:43770058-43778109 (-)
AKR/J	ENSMUSG00220035164	protein coding gene	Chr17:42763893-42771940 (-)
BALB/cJ	ENSMUSG00180019075	protein coding gene	Chr17:43520232-43528281 (-)
C3H/HeJ	ENSMUSG00175014611	protein coding gene	Chr17:42834139-42842190 (-)
C57BL/6NJ	ENSMUSG00215015135	protein coding gene	Chr17:42389479-42397528 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021687	protein coding gene	Chr17:43469105-43477285 (-)
CAST/EiJ	ENSTCUG00005022530	protein coding gene	Chr17:43551590-43560065 (-)
CBA/J	ENSMUSG00210031246	protein coding gene	Chr17:42583831-42591879 (-)
DBA/2J	ENSMUSG00185028811	protein coding gene	Chr17:45489228-45497277 (-)
FVB/NJ	ENSMUSG00205052351	protein coding gene	Chr17:43059950-43067998 (-)
JF1/MsJ	ENSUMUG00000030261	protein coding gene	Chr17:45107710-45115781 (-)
LP/J	ENSMUSG00230041401	protein coding gene	Chr17:46381769-46390031 (-)
NOD/ShiLtJ	ENSMUSG00190015824	protein coding gene	Chr17:42471256-42479327 (-)
NZO/HlLtJ	ENSMUSG00225043069	protein coding gene	Chr17:48636467-48644514 (-)
PWK/PhJ	ENSLUMG00010029629	protein coding gene	Chr17:42343607-42351680 (-)
SPRET/EiJ	ENSMSPG00010033308	protein coding gene	Chr17:42548084-42556189 (-)
WSB/EiJ	ENSIUOG00005025656	protein coding gene	Chr17:43432574-43440838 (-)

Human Ortholog

PTCRA, pre T cell antigen receptor alpha

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTCRA, pre T cell antigen receptor alpha
Synonyms

IMD126, PTA, PT-ALPHA
Links

HGNC:21290

NCBI Gene ID: 171558

UniProt: Q6ISU1
Chr Location

6p21.1; chr6:42915989-42925838 (+) GRCh38

MGI Vertebrate Homology

Ptcra stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTCRA
Gene Tree

Ptcra

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Phenotype Summary

11 phenotypes from 3 alleles in 4 genetic backgrounds
8 phenotypes from multigenic genotypes
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Endonuclease-mediated

4
Gene trapped

15
Targeted

8
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a knock-out allele show thymus hypoplasia, arrested T cell differentiation, decreased DN4 cell number, and increased DN3 T cell number. Homozygotes for a knock-in allele show decreased double-positive T cell count, increased DN3 number, and increased gamma-delta T cell number.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

603
Tissues

6
cDNA Data

7
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

31
RefSeq

2
UniProt

2
CCDS

CCDS28840.1

Ensembl

ENSMUSG00000036858 (Evidence)
NCBI Gene

19208

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036858	Ensembl Gene Model \| MGI Sequence Detail	8050	C57BL/6J	± kb
transcript	ENSMUST00000041012	Ensembl \| MGI Sequence Detail	1283	Not Applicable
polypeptide	ENSMUSP00000035683	Ensembl \| MGI Sequence Detail	199	Not Applicable

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UniProt

2 Sequences
InterPro Domains

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR027834 Pre-T-cell antigen receptor
GlyGen

P0C6B2 2 sites

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All nucleic 11

Genomic 3

cDNA 7

Primer pair 1

Microarray probesets 3

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MGD-MRK-28154

Summaries

All 100

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 66
Earliest

J:39556 Kishi H, et al., Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells. EMBO J. 1991 Jan;10(1):93-100
Latest

J:386202 Mejia-Ramirez E, et al., Targeting RhoA nuclear mechanoactivity rejuvenates aged hematopoietic stem cells. Nat Aging. 2026 Jan;6(1):68-87

TSS for Ptcra:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr148396	Chr17:47074718-47074734 (-)	-88 bp
Tssr148395	Chr17:47074698-47074705 (-)	-64 bp
Tssr148394	Chr17:47074674-47074692 (-)	-45 bp
Tssr148393	Chr17:47074653-47074667 (-)	-22 bp
Tssr148392	Chr17:47074641-47074650 (-)	-8 bp
Tssr148391	Chr17:47074617-47074634 (-)	12 bp
Tssr148390	Chr17:47074573-47074601 (-)	51 bp
Tssr148389	Chr17:47074502-47074570 (-)	102 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24