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Prkar1a Gene Detail
Summary
  • Symbol
    Prkar1a
  • Name
    protein kinase, cAMP dependent regulatory, type I, alpha
  • Synonyms
    1300018C22Rik, RIalpha, Tse-1, Tse1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104878
    NCBI Gene: 19084
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:109540231-109560482 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 72.33 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    575 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104878
 protein coding gene Chr11:109539849-109560489 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019337
 protein coding gene Chr11:113224045-113244304 (+)
A/J MGP_AJ_G0019305
 protein coding gene Chr11:108322282-108343277 (+)
AKR/J MGP_AKRJ_G0019274
 protein coding gene Chr11:111580977-111603197 (+)
BALB/cJ MGP_BALBcJ_G0019279
 protein coding gene Chr11:108754318-108774555 (+)
C3H/HeJ MGP_C3HHeJ_G0019088
 protein coding gene Chr11:111876670-111896924 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019729
 protein coding gene Chr11:116651040-116672394 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017352
 protein coding gene Chr11:105545365-105565812 (+)
CAST/EiJ MGP_CASTEiJ_G0018641
 protein coding gene Chr11:113016131-113036361 (+)
CBA/J MGP_CBAJ_G0019057
 protein coding gene Chr11:121468471-121489110 (+)
DBA/2J MGP_DBA2J_G0019169
 protein coding gene Chr11:107801485-107822928 (+)
FVB/NJ MGP_FVBNJ_G0019160
 protein coding gene Chr11:107288129-107308379 (+)
LP/J MGP_LPJ_G0019239
 protein coding gene Chr11:113635846-113655735 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019191
 protein coding gene Chr11:120607004-120629612 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019766
 protein coding gene Chr11:112140437-112160693 (+)
PWK/PhJ MGP_PWKPhJ_G0018406
 protein coding gene Chr11:108967931-108988895 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018198
 protein coding gene Chr11:111924286-111944414 (+)
WSB/EiJ MGP_WSBEiJ_G0018693
 protein coding gene Chr11:112063622-112083538 (+)



Homology
more
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAR1A, protein kinase cAMP-dependent type I regulatory subunit alpha
  • Synonyms
    ACRDYS1, ADOHR, CAR, CNC, CNC1, PKR1, PPNAD1, PRKAR1, Prkar1alpha, TSE1
  • Links
    NCBI Gene ID: 5573
    neXtProt AC: NX_P10644
    UniProt: P10644

  • Chr Location
    17q24.2; chr17:68413623-68551319 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Prkar1a mouse models; 3 with human PRKAR1A associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 4 models
      
IDs
 View 2 models
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    95 phenotypes from 6 alleles in 12 genetic backgrounds
    22 phenotypes from multigenic genotypes
    9 images
    79 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality during organogenesis due to developmental patterning defects. Mice heterozygous for a null allele exhibit background sensitive infertility and increased tumor incidence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    875
  • Tissues
    91
  • cDNA Data
    35
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020612 Ensembl Gene Model | MGI Sequence Detail 20252 C57BL/6J ±  kb
    transcript ENSMUST00000106677 Ensembl | MGI Sequence Detail 3513 Not Applicable  
    polypeptide ENSMUSP00000102288 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000013228 cAMP-dependent protein kinase type I-alpha regulatory subunit
      (term hierarchy)
    • InterPro Domains
      IPR050503 cAMP-dependent kinase regulatory chain
      IPR012198 cAMP-dependent protein kinase regulatory subunit
      IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding domain superfamily
      IPR014710 RmlC-like jelly roll fold
    • GlyGen
      Q9DBC7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 36
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15266, MGD-MRK-15269, MGD-MRK-29031, MGI:1914726
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 18
      Diseases 8
      Gene Ontology 22
      Phenotypes 79
    • Earliest
      J:7538 Killary AM, et al., A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep;38(2):523-34
    • Latest
      J:343426 Malawsky DS, et al., Chronic AMPK inactivation slows SHH medulloblastoma progression by inhibiting mTORC1 signaling and depleting tumor stem cells. iScience. 2023 Dec 15;26(12):108443
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory