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Gpx5 Gene Detail
Summary
  • Symbol
    Gpx5
  • Name
    glutathione peroxidase 5
  • Synonyms
    Arep
  • Feature Type
    protein coding gene
  • IDs
    MGI:104886
    NCBI Gene: 14780
  • Alliance
    gene page
  • Transcription Start Sites
    33 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:21470599-21476897 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 7.73 cM, cytoband A2-A4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104886
 protein coding gene Chr13:21470599-21476901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020270
 protein coding gene Chr13:18536647-18545289 (-)
A/J MGP_AJ_G0020226
 protein coding gene Chr13:18137791-18144092 (-)
AKR/J MGP_AKRJ_G0020202
 protein coding gene Chr13:18441539-18447840 (-)
BALB/cJ MGP_BALBcJ_G0020214
 protein coding gene Chr13:18188430-18194732 (-)
C3H/HeJ MGP_C3HHeJ_G0020015
 protein coding gene Chr13:18535126-18541419 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020658
 protein coding gene Chr13:19192575-19198934 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018265
 protein coding gene Chr13:16505808-16512007 (-)
CAST/EiJ MGP_CASTEiJ_G0019552
 protein coding gene Chr13:18333338-18339585 (-)
CBA/J MGP_CBAJ_G0019979
 protein coding gene Chr13:19859361-19865653 (-)
DBA/2J MGP_DBA2J_G0020100
 protein coding gene Chr13:17774161-17780460 (-)
FVB/NJ MGP_FVBNJ_G0020082
 protein coding gene Chr13:17442146-17448439 (-)
LP/J MGP_LPJ_G0020171
 protein coding gene Chr13:18782713-18789010 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020120
 protein coding gene Chr13:20258411-20264712 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020686
 protein coding gene Chr13:18260907-18267200 (-)
PWK/PhJ MGP_PWKPhJ_G0019315
 protein coding gene Chr13:17824962-17831324 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019121
 protein coding gene Chr13:17269475-17275636 (-)
WSB/EiJ MGP_WSBEiJ_G0019609
 protein coding gene Chr13:18338524-18344824 (-)



Homology
more
  • Human Ortholog
    GPX5, glutathione peroxidase 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPX5, glutathione peroxidase 5
  • Synonyms
    EGLP, GPx-5, GSHPx-5, HEL-S-75p
  • Links
    NCBI Gene ID: 2880
    neXtProt AC: NX_O75715
    UniProt: O75715

  • Chr Location
    6p22.1; chr6:28525881-28534955 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a knock-out allele exhibit age-dependent reduced fertility due to increased sensitivity of sperm DNA to oxidative attack.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    104
  • cDNA Data
    14
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14780 NCBI Gene Model | MGI Sequence Detail 6299 C57BL/6J ±  kb
    transcript NM_010343 RefSeq | MGI Sequence Detail 1629 ZRU/MplStud  
    polypeptide P21765 UniProt | EBI | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 14
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1389, MGD-MRK-29039, MGI:2145402
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory