Ubp1 MGI Mouse Gene Detail - MGI:104889 - upstream binding protein 1

Symbol

Ubp1
Name

upstream binding protein 1
Synonyms

LBP-1a, LBP-1b, NF2d9

Feature Type

protein coding gene
IDs

MGI:104889
NCBI Gene: 22221
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr9:113760002-113806270 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 64.14 cM, cytoband F2
Mapping Data

2 experiments

SNPs within 2kb

869 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104889	protein coding gene	Chr9:113760002-113807095 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035381	protein coding gene	Chr9:116318128-116369241 (+)
A/J	MGP_AJ_G0035362	protein coding gene	Chr9:111987677-112037522 (+)
AKR/J	MGP_AKRJ_G0035293	protein coding gene	Chr9:114841147-114890806 (+)
BALB/cJ	MGP_BALBcJ_G0035357	protein coding gene	Chr9:111812621-111860001 (+)
C3H/HeJ	MGP_C3HHeJ_G0035065	protein coding gene	Chr9:115360566-115410699 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035878	protein coding gene	Chr9:119476566-119524007 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032765	protein coding gene	Chr9:109139746-109186570 (+)
CAST/EiJ	MGP_CASTEiJ_G0034371	protein coding gene	Chr9:115217511-115265707 (+)
CBA/J	MGP_CBAJ_G0035032	protein coding gene	Chr9:123874972-123929805 (+)
DBA/2J	MGP_DBA2J_G0035190	protein coding gene	Chr9:111457271-111506410 (+)
FVB/NJ	MGP_FVBNJ_G0035137	protein coding gene	Chr9:110277582-110324594 (+)
LP/J	MGP_LPJ_G0035270	protein coding gene	Chr9:116611876-116662870 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035178	protein coding gene	Chr9:125121531-125175712 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035899	protein coding gene	Chr9:115244973-115293053 (+)
PWK/PhJ	MGP_PWKPhJ_G0034076	protein coding gene	Chr9:111750590-111799359 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033911	protein coding gene	Chr9:115300280-115346714 (+)
WSB/EiJ	MGP_WSBEiJ_G0034491	protein coding gene	Chr9:115085710-115138419 (+)

Human Ortholog

UBP1, upstream binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBP1, upstream binding protein 1
Synonyms

LBP-1a, LBP1A, LBP-1B, LBP1B
Links

HGNC:12507

NCBI Gene ID: 7342

neXtProt AC: NX_Q9NZI7

UniProt: Q9NZI7
Chr Location

3p22.3; chr3:33388336-33441399 (-) GRCh38

MGI Vertebrate Homology

Ubp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: UBP1
Gene Tree

Ubp1

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Endonuclease-mediated

1
Gene trapped

20
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

33 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die during gestation.

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All GO Annotations

14
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

170
cDNA Data

19
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ubp1

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All Sequences

93
RefSeq

41
UniProt

3
CCDS

CCDS40788.1, CCDS40789.1

Ensembl

ENSMUSG00000009741 (Evidence)
NCBI Gene

22221

			Length	Strain/Species	Flank
genomic	ENSMUSG00000009741	Ensembl Gene Model \| MGI Sequence Detail	46269	C57BL/6J	± kb
transcript	ENSMUST00000084885	Ensembl \| MGI Sequence Detail	3850	Not Applicable
polypeptide	ENSMUSP00000081946	Ensembl \| MGI Sequence Detail	540	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017006 upstream-binding protein 1

(term hierarchy)
InterPro Domains

IPR007604 CP2 transcription factor

IPR041418 SAM domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR040167 Transcription factor CP2-like

IPR037600 Upstream-binding protein 1, SAM domain

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All nucleic 22

cDNA 21

Primer pair 1

Microarray probesets 5

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MGD-MRK-29042

Summaries

All 51

Developmental Gene Expression 10

Gene Ontology 4

Phenotypes 14
Earliest

J:5178 Sanno Y, et al., Studies of a mutation affecting pyrimidine degradation in inbred mice. J Biol Chem. 1970 Nov 10;245(21):5668-76
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ubp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr87539	Chr9:113760032-113760055 (+)	42 bp
Tssr87540	Chr9:113760058-113760134 (+)	94 bp
Tssr87541	Chr9:113760206-113760256 (+)	229 bp
Tssr87542	Chr9:113760376-113760385 (+)	379 bp
Tssr87543	Chr9:113785039-113785051 (+)	25,043 bp
Tssr87544	Chr9:113785052-113785079 (+)	25,064 bp
Tssr87545	Chr9:113785088-113785095 (+)	25,090 bp
Tssr87546	Chr9:113785111-113785116 (+)	25,112 bp
Tssr87547	Chr9:113785290-113785301 (+)	25,294 bp
Tssr87548	Chr9:113785750-113785755 (+)	25,751 bp
Tssr87549	Chr9:113787765-113787780 (+)	27,771 bp
Tssr87550	Chr9:113798277-113798284 (+)	38,279 bp
Tssr87551	Chr9:113798289-113798297 (+)	38,291 bp
Tssr87552	Chr9:113798304-113798320 (+)	38,310 bp
Tssr87553	Chr9:113805355-113805382 (+)	45,367 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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