Rest MGI Mouse Gene Detail - MGI:104897 - RE1-silencing transcription factor

Symbol

Rest
Name

RE1-silencing transcription factor
Synonyms

2610008J04Rik, NRSF

Feature Type

protein coding gene
IDs

MGI:104897
NCBI Gene: 19712
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr5:77413338-77434279 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 41.61 cM
Mapping Data

2 experiments

SNPs within 2kb

569 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104897	protein coding gene	Chr5:77413273-77434279 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029656	protein coding gene	Chr5:77523638-77551030 (+)
A/J	MGP_AJ_G0029624	protein coding gene	Chr5:74537150-74558134 (+)
AKR/J	MGP_AKRJ_G0029572	protein coding gene	Chr5:76985602-77010734 (+)
BALB/cJ	MGP_BALBcJ_G0029633	protein coding gene	Chr5:75275747-75296664 (+)
C3H/HeJ	MGP_C3HHeJ_G0029356	protein coding gene	Chr5:77345190-77366983 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030087	protein coding gene	Chr5:80609485-80634240 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0028764	protein coding gene	Chr5:76571843-76593730 (+)
CBA/J	MGP_CBAJ_G0029325	protein coding gene	Chr5:83289542-83315599 (+)
DBA/2J	MGP_DBA2J_G0029470	protein coding gene	Chr5:74594600-74615799 (+)
FVB/NJ	MGP_FVBNJ_G0029431	protein coding gene	Chr5:73803802-73825574 (+)
LP/J	MGP_LPJ_G0029557	protein coding gene	Chr5:77938647-77961064 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029459	protein coding gene	Chr5:86381223-86404634 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030120	protein coding gene	Chr5:76533692-76556440 (+)
PWK/PhJ	MGP_PWKPhJ_G0028487	protein coding gene	Chr5:73619109-73640257 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028322	protein coding gene	Chr5:75913810-75936531 (+)
WSB/EiJ	MGP_WSBEiJ_G0028844	protein coding gene	Chr5:76860131-76881576 (+)

Human Ortholog

REST, RE1 silencing transcription factor

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

REST, RE1 silencing transcription factor
Synonyms

DFNA27, GINGF5, HGF5, NRSF, WT6, XBR
Links

HGNC:9966

NCBI Gene ID: 5978

neXtProt AC: NX_Q13127

UniProt: Q13127
Chr Location

4q12; chr4:56907876-56966808 (+) GRCh38

MGI Vertebrate Homology

Rest stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: REST
Gene Tree

Rest

Diseases

3 with human REST associations

				Human Disease	Mouse Models
				autosomal dominant nonsyndromic deafness 27 IDs autosomal dominant nonsyndromic deafness 27 DOID:0110556 ICD10CM:H90.3 OMIM:612431
				gingival fibromatosis 5 IDs gingival fibromatosis 5 DOID:0080280 OMIM:617626
				nephroblastoma IDs nephroblastoma DOID:2154 DOID:5177 DOID:5180 MESH:D009396 NCI:C27730 NCI:C3267 NCI:C6180 OMIM:194070 UMLS_CUI:C0027708 UMLS_CUI:C1332219 UMLS_CUI:C1333015

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

39 phenotypes from 10 alleles in 15 genetic backgrounds
6 phenotypes from multigenic genotypes
71 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

154
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

129
Spontaneous

1
Targeted

19
Genomic Mutations

3 involving Rest
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

96 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Targeted mutation of this gene results in embryonic lethality preceded by growth retardation and abnormal cellular organization in several tissues, including the hindbrain and somites. Mice with conditional deletions exhibit increased apoptosis in affected cells.

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All GO Annotations

132
GO References

27

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1018
Tissues

172
cDNA Data

20
Literature Summary

53

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA REST

Xenbase rest

ZFIN rest

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All Sequences

58
RefSeq

6
UniProt

3
CCDS

CCDS19372.1

Ensembl

ENSMUSG00000029249 (Evidence)
NCBI Gene

19712

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029249	Ensembl Gene Model \| MGI Sequence Detail	20942	C57BL/6J	± kb
transcript	ENSMUST00000080359	Ensembl \| MGI Sequence Detail	7004	Not Applicable
polypeptide	ENSMUSP00000079231	Ensembl \| MGI Sequence Detail	1082	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000013894 RE1-silencing transcription factor

(term hierarchy)
InterPro Domains

IPR050688 Zinc finger and ubiquitin peptidase domain-containing protein

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type
GlyGen

Q8VIG1 1 site, 1 O-linked glycan (1 site)

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All nucleic 37

cDNA 21

Primer pair 14

Other 2

Microarray probesets 7

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MGD-MRK-29050, MGI:1919377

Summaries

All 194

Developmental Gene Expression 53

Gene Ontology 27

Phenotypes 71
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:356769 Islam M, et al., Ablation of placental REST deregulates fetal brain metabolism and impacts gene expression of the offspring brain at the postnatal and adult stages. FASEB J. 2024 Jan;38(1):e23349

TSS for Rest:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr46778	Chr5:77413301-77413396 (+)	11 bp
Tssr46779	Chr5:77414003-77414018 (+)	673 bp
Tssr1516	Chr5:77414031-77414056 (+)	706 bp
Tssr46780	Chr5:77414063-77414079 (+)	733 bp
Tssr46781	Chr5:77414080-77414091 (+)	748 bp
Tssr46782	Chr5:77414126-77414140 (+)	795 bp
Tssr46783	Chr5:77414212-77414236 (+)	886 bp
Tssr46784	Chr5:77416584-77416604 (+)	3,256 bp
Tssr46785	Chr5:77428633-77428643 (+)	15,300 bp
Tssr46786	Chr5:77431817-77431823 (+)	18,482 bp
Tssr46787	Chr5:77433515-77433528 (+)	20,184 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24