Tead2 MGI Mouse Gene Detail - MGI:104904 - TEA domain family member 2

Symbol

Tead2
Name

TEA domain family member 2
Synonyms

Etdf, TEAD-2, TEF-4

Feature Type

protein coding gene
IDs

MGI:104904
NCBI Gene: 21677
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:44865216-44882892 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.19 cM, cytoband B5
Mapping Data

7 experiments

SNPs within 2kb

507 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104904	protein coding gene	Chr7:44865177-44883068 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032210	protein coding gene	Chr7:45457629-45476871 (+)
A/J	MGP_AJ_G0032189	protein coding gene	Chr7:44590524-44608065 (+)
AKR/J	MGP_AKRJ_G0032125	protein coding gene	Chr7:45821351-45838798 (+)
BALB/cJ	MGP_BALBcJ_G0032201	protein coding gene	Chr7:44590218-44607715 (+)
C3H/HeJ	MGP_C3HHeJ_G0031917	protein coding gene	Chr7:46314024-46331234 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032693	protein coding gene	Chr7:47724487-47741895 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029707	protein coding gene	Chr7:47153084-47170916 (+)
CAST/EiJ	MGP_CASTEiJ_G0031245	protein coding gene	Chr7:37711009-37730156 (+)
CBA/J	MGP_CBAJ_G0031881	protein coding gene	Chr7:49293270-49312047 (+)
DBA/2J	MGP_DBA2J_G0032039	protein coding gene	Chr7:44263654-44281501 (+)
FVB/NJ	MGP_FVBNJ_G0031990	protein coding gene	Chr7:44039799-44057095 (+)
LP/J	MGP_LPJ_G0032117	protein coding gene	Chr7:46139789-46159250 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032027	protein coding gene	Chr7:48003545-48021684 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032709	protein coding gene	Chr7:45041512-45059781 (+)
PWK/PhJ	MGP_PWKPhJ_G0030968	protein coding gene	Chr7:37629274-37647442 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030805	protein coding gene	Chr7:33055122-33072428 (+)
WSB/EiJ	MGP_WSBEiJ_G0031362	protein coding gene	Chr7:45533400-45552799 (+)

Human Ortholog

TEAD2, TEA domain transcription factor 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEAD2, TEA domain transcription factor 2
Synonyms

ETF, TEAD-2, TEF-4, TEF4
Links

HGNC:11715

NCBI Gene ID: 8463

neXtProt AC: NX_Q15562

UniProt: Q15562
Chr Location

19q13.33; chr19:49340595-49362457 (-) GRCh38

MGI Vertebrate Homology

Tead2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: TEAD2
Protein SuperFamily

TEF
Gene Tree

Tead2

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
29 phenotypes from multigenic genotypes
2 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

35
Endonuclease-mediated

3
Gene trapped

25
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a functionally null allele of this gene exhibit no gross abnormalities and are fertile.

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All GO Annotations

46
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1381
Tissues

197
cDNA Data

25
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

81
RefSeq

10
UniProt

11
CCDS

CCDS21236.1, CCDS71957.1

Ensembl

ENSMUSG00000030796 (Evidence)
NCBI Gene

21677

			Length	Strain/Species	Flank
genomic	21677	NCBI Gene Model \| MGI Sequence Detail	17677	C57BL/6J	± kb
transcript	NM_001379272	RefSeq \| MGI Sequence Detail	2359	ZRU/MplStud
polypeptide	P48301	UniProt \| EBI \| MGI Sequence Detail	445	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000016219 transcriptional enhancer factor TEF-4

(term hierarchy)
InterPro Domains

IPR000818 TEA/ATTS domain

IPR038096 TEA/ATTS domain superfamily

IPR050937 TEC1/TEAD Transcription Factor

IPR016361 Transcriptional enhancer factor, metazoa

IPR041086 YAP binding domain

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All nucleic 34

Genomic 3

cDNA 25

Primer pair 5

Other 1

Microarray probesets 4

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MGD-MRK-29058

Summaries

All 84

Developmental Gene Expression 39

Gene Ontology 12

Phenotypes 13
Earliest

J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
Latest

J:341688 Xie X, et al., SRSF2 in Sertoli cells is essential for testicular development and spermatogenesis in mice. FASEB J. 2023 May;37(5):e22918

TSS for Tead2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr66496	Chr7:44865197-44865240 (+)	3 bp
Tssr66497	Chr7:44866095-44866119 (+)	891 bp
Tssr66498	Chr7:44866732-44866759 (+)	1,530 bp
Tssr66499	Chr7:44869872-44869883 (+)	4,662 bp
Tssr66500	Chr7:44869889-44869902 (+)	4,680 bp
Tssr66501	Chr7:44869907-44869934 (+)	4,705 bp
Tssr66502	Chr7:44875076-44875130 (+)	9,887 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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