Tnfaip2 Gene Detail

Summary

• Symbol
  Tnfaip2
• Name
  tumor necrosis factor, alpha-induced protein 2
• Synonyms
  Exoc3l3, M-sec, Tnfip2

• Feature Type
  protein coding gene
• IDs
  MGI:104960
  NCBI Gene: 21928
• Alliance
  gene page
• Transcription Start Sites
  36 TSS

Location &
Maps

• Sequence Map
  Chr12:111408903-111421452 bp, + strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 60.99 cM
• Mapping Data
  7 experiments

Strain
Comparison

• SNPs within 2kb
  374 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104960	protein coding gene	Chr12:111408898-111421452 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020133	protein coding gene	Chr12:113829264-113841806 (+)
A/J	MGP_AJ_G0020089	protein coding gene	Chr12:109451359-109464527 (+)
AKR/J	MGP_AKRJ_G0020064	protein coding gene	Chr12:112586168-112598740 (+)
BALB/cJ	MGP_BALBcJ_G0020074	protein coding gene	Chr12:109868036-109880588 (+)
C3H/HeJ	MGP_C3HHeJ_G0019876	protein coding gene	Chr12:113086915-113099445 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020519	protein coding gene	Chr12:117361596-117374237 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018132	protein coding gene	Chr12:105893468-105906028 (+)
CAST/EiJ	MGP_CASTEiJ_G0019417	protein coding gene	Chr12:107925414-107937977 (+)
CBA/J	MGP_CBAJ_G0019843	protein coding gene	Chr12:121828283-121840810 (+)
DBA/2J	MGP_DBA2J_G0019960	protein coding gene	Chr12:108933043-108945576 (+)
FVB/NJ	MGP_FVBNJ_G0019945	protein coding gene	Chr12:107730437-107743020 (+)
LP/J	MGP_LPJ_G0020035	protein coding gene	Chr12:113643794-113656348 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019983	protein coding gene	Chr12:124952924-124966692 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020548	protein coding gene	Chr12:112096009-112108561 (+)
PWK/PhJ	MGP_PWKPhJ_G0019178	protein coding gene	Chr12:103571094-103584296 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018981	protein coding gene	Chr12:106254456-106266878 (+)
WSB/EiJ	MGP_WSBEiJ_G0019476	protein coding gene	Chr12:113019017-113032558 (+)

Homology

• Human Ortholog
  TNFAIP2, TNF alpha induced protein 2

• Vertebrate Orthologs
  4

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  TNFAIP2, TNF alpha induced protein 2
  
• Synonyms
  B94, EXOC3L3
• Links
  HGNC:11895

  NCBI Gene ID: 7127

  neXtProt AC: NX_Q03169

  UniProt: Q03169

  
  
• Chr Location
  14q32.32; chr14:103121469-103137439 (+)  GRCh38

---

• MGI Vertebrate Homology
  Tnfaip2 stringent orthology
  1 human;1 mouse;1 rat;2 zebrafish
  
• HCOP
  vertebrate homology predictions: TNFAIP2
• Gene Tree
  Tnfaip2
  

Human Diseases

• Diseases
  1 with Tnfaip2 mouse models

Human Disease

Mouse Models

focal segmental glomerulosclerosis

IDs

focal segmental glomerulosclerosis      

DOID:1312
DOID:3945
EFO:0004236
MESH:D005923
NCI:C37308
OMIM:PS603278
UMLS_CUI:C0017668

View 1 model

Mouse Models

Human Disease Modeled: focal segmental glomerulosclerosis

Allelic Composition	Genetic Background	Reference	Phenotypes
Tnfaip2tm1.1Ohno/Tnfaip2tm1.1Ohno	C.Cg-Tnfaip2^tm1.1Ohno	J:343202	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  13 phenotypes from 1 allele in 1 genetic background
  10 phenotype references
  

• All Mutations and Alleles
  9
• Endonuclease-mediated
  2
• Gene trapped
  2
• Targeted
  5
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  33 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice develop albuminuria, podocyte injury, with mitochondrial abnormalities and progressive focal segmental glomerulosclerosis.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  8
• GO References
  3

Expression

• Assay Results
  782
• Tissues
  66
• cDNA Data
  14
• Literature Summary
  4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase tnfaip2
  ZFIN tnfaip2b

Sequences &
Gene Models

• All Sequences
  78
• RefSeq
  7
• UniProt
  9
• CCDS
  CCDS26178.2

• Ensembl
  ENSMUSG00000021281 (Evidence)
• NCBI Gene
  21928

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000021281	Ensembl Gene Model | MGI Sequence Detail	12550	C57BL/6J
transcript	ENSMUST00000109792	Ensembl | MGI Sequence Detail	3284	Not Applicable
polypeptide	ENSMUSP00000105415	Ensembl | MGI Sequence Detail	708	Not Applicable

Protein
Information

• UniProt
  9 Sequences
• Protein Ontology
  PR:000016473 tumor necrosis factor alpha-induced protein 2
  (term hierarchy)
• PDB
  5B86
• InterPro Domains
  IPR010326 Exocyst complex component EXOC3/Sec6
  IPR042532 Exocyst complex component EXOC3/Sec6, C-terminal domain

Molecular
Reagents

• All nucleic 15

  cDNA 14

  Primer pair 1

  
  

  Microarray probesets 5

Other
Accession IDs

MGD-MRK-15152, MGD-MRK-31033

References

• Summaries
  All 39

  Developmental Gene Expression 4

  Diseases 1

  Gene Ontology 3

  Phenotypes 10
• Earliest
  J:16743 Wolf FW, et al., B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome. J Biol Chem. 1994 Feb 4;269(5):3633-40
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnfaip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115280	Chr12:111408857-111408869 (+)	-40 bp
Tssr115281	Chr12:111408887-111408914 (+)	-2 bp
Tssr115282	Chr12:111408969-111408981 (+)	72 bp
Tssr115283	Chr12:111409087-111409103 (+)	192 bp
Tssr115284	Chr12:111411505-111411533 (+)	2,616 bp
Tssr115285	Chr12:111412399-111412431 (+)	3,512 bp
Tssr115286	Chr12:111412435-111412452 (+)	3,541 bp
Tssr115287	Chr12:111412455-111412470 (+)	3,560 bp
Tssr115288	Chr12:111415973-111415999 (+)	7,083 bp
Tssr115289	Chr12:111416058-111416085 (+)	7,169 bp
Tssr115290	Chr12:111416272-111416287 (+)	7,377 bp
Tssr115291	Chr12:111416323-111416328 (+)	7,423 bp
Tssr115292	Chr12:111416947-111416957 (+)	8,049 bp
Tssr115293	Chr12:111418289-111418311 (+)	9,397 bp
Tssr115294	Chr12:111418413-111418422 (+)	9,515 bp
Tssr115295	Chr12:111418498-111418517 (+)	9,605 bp
Tssr115296	Chr12:111418527-111418538 (+)	9,630 bp
Tssr115297	Chr12:111418540-111418561 (+)	9,648 bp
Tssr115298	Chr12:111418569-111418643 (+)	9,703 bp
Tssr115299	Chr12:111418644-111418679 (+)	9,759 bp
Tssr115300	Chr12:111418680-111418696 (+)	9,785 bp
Tssr115301	Chr12:111418736-111418762 (+)	9,846 bp
Tssr115302	Chr12:111418771-111418787 (+)	9,876 bp
Tssr115303	Chr12:111418879-111418920 (+)	9,997 bp
Tssr115304	Chr12:111420182-111420192 (+)	11,284 bp
Tssr115305	Chr12:111420333-111420345 (+)	11,436 bp
Tssr115306	Chr12:111420653-111420664 (+)	11,756 bp
Tssr115307	Chr12:111420679-111420711 (+)	11,792 bp
Tssr115308	Chr12:111420719-111420731 (+)	11,822 bp
Tssr115309	Chr12:111420738-111420760 (+)	11,846 bp
Tssr115310	Chr12:111420806-111420832 (+)	11,916 bp
Tssr115311	Chr12:111420845-111420857 (+)	11,948 bp
Tssr115312	Chr12:111420864-111420875 (+)	11,967 bp
Tssr115313	Chr12:111420877-111420895 (+)	11,983 bp
Tssr115314	Chr12:111420903-111420915 (+)	12,006 bp
Tssr115315	Chr12:111421098-111421109 (+)	12,201 bp