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Npy1r Gene Detail
Summary
  • Symbol
    Npy1r
  • Name
    neuropeptide Y receptor Y1
  • Synonyms
    Npyr, Y1-R
  • Feature Type
    protein coding gene
  • IDs
    MGI:104963
    NCBI Gene: 18166
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:67149844-67159444 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 33.15 cM, cytoband B3-C2
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    314 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104963
 protein coding gene Chr8:67149595-67159452 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033654
 protein coding gene Chr8:66758033-66767608 (+)
A/J MGP_AJ_G0033636
 protein coding gene Chr8:64011428-64020793 (+)
AKR/J MGP_AKRJ_G0033561
 protein coding gene Chr8:65774220-65783599 (+)
BALB/cJ MGP_BALBcJ_G0033632
 protein coding gene Chr8:64222775-64232145 (+)
C3H/HeJ MGP_C3HHeJ_G0033342
 protein coding gene Chr8:66550716-66560077 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034149
 protein coding gene Chr8:69266670-69276047 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031096
 protein coding gene Chr8:59080171-59089464 (+)
CAST/EiJ MGP_CASTEiJ_G0032667
 protein coding gene Chr8:65951985-65966088 (+)
CBA/J MGP_CBAJ_G0033320
 protein coding gene Chr8:71838364-71849902 (+)
DBA/2J MGP_DBA2J_G0033474
 protein coding gene Chr8:63754338-63764134 (+)
FVB/NJ MGP_FVBNJ_G0033415
 protein coding gene Chr8:62960923-62970391 (+)
LP/J MGP_LPJ_G0033562
 protein coding gene Chr8:66817697-66827074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033459
 protein coding gene Chr8:74472041-74481407 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034167
 protein coding gene Chr8:66105605-66115995 (+)
PWK/PhJ MGP_PWKPhJ_G0032376
 protein coding gene Chr8:63045332-63055086 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032212
 protein coding gene Chr8:65032531-65041881 (+)
WSB/EiJ MGP_WSBEiJ_G0032784
 protein coding gene Chr8:66468643-66478656 (+)



Homology
more
  • Human Ortholog
    NPY1R, neuropeptide Y receptor Y1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPY1R, neuropeptide Y receptor Y1
  • Synonyms
    NPY1-R, NPYR
  • Links
    NCBI Gene ID: 4886
    neXtProt AC: NX_P25929
    UniProt: P25929

  • Chr Location
    4q32.2; chr4:163323962-163344832 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Npy1r mouse models; 5 with human NPY1R associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    89 phenotypes from 7 alleles in 8 genetic backgrounds
    16 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit moderate obesity, mild hyperinsulinemia, reduced activity and energy expenditure, lowered fast-induced refeeding, hyperalgesia, increased neuropathic pain, and resistance to barbiturates.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    865
  • Tissues
    79
  • cDNA Data
    14
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036437 Ensembl Gene Model | MGI Sequence Detail 9601 C57BL/6J ±  kb
    transcript ENSMUST00000039303 Ensembl | MGI Sequence Detail 3001 Not Applicable  
    polypeptide ENSMUSP00000045530 Ensembl | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      Genomic 6
      cDNA 15
      Primer pair 8
      Other 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12929, MGD-MRK-31036
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 10
      Phenotypes 75
    • Earliest
      J:3466 Eva C, et al., The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 1992 Dec 21;314(3):285-8
    • Latest
      J:353900 Zhang Y, et al., Feedforward inhibition of stress by brainstem neuropeptide Y neurons. Nat Commun. 2024 Sep 1;15(1):7603
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory