Srxn1 MGI Mouse Gene Detail - MGI:104971 - sulfiredoxin 1 homolog (S. cerevisiae)

Symbol

Srxn1
Name

sulfiredoxin 1 homolog (S. cerevisiae)
Synonyms

1700127B04Rik, Npn3, Srx, Srx1

Feature Type

protein coding gene
IDs

MGI:104971
NCBI Gene: 76650
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr2:151947436-151953296 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 74.83 cM, cytoband H1
Mapping Data

3 experiments

SNPs within 2kb

218 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104971	protein coding gene	Chr2:151946738-151953296 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026651	protein coding gene	Chr2:156631192-156637044 (+)
A/J	MGP_AJ_G0026617	protein coding gene	Chr2:150388547-150397387 (+)
AKR/J	MGP_AKRJ_G0026587	protein coding gene	Chr2:154772571-154778426 (+)
BALB/cJ	MGP_BALBcJ_G0026626	protein coding gene	Chr2:150703456-150709316 (+)
C3H/HeJ	MGP_C3HHeJ_G0026369	protein coding gene	Chr2:155165027-155170895 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027075	protein coding gene	Chr2:161194650-161202250 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024446	protein coding gene	Chr2:143994511-144000164 (+)
CAST/EiJ	MGP_CASTEiJ_G0025830	protein coding gene	Chr2:155394499-155400393 (+)
CBA/J	MGP_CBAJ_G0026347	protein coding gene	Chr2:167100961-167106813 (+)
DBA/2J	MGP_DBA2J_G0026483	protein coding gene	Chr2:149608097-149614395 (+)
FVB/NJ	MGP_FVBNJ_G0026448	protein coding gene	Chr2:148042852-148048941 (+)
LP/J	MGP_LPJ_G0026587	protein coding gene	Chr2:156787092-156792965 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026470	protein coding gene	Chr2:171234274-171241505 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027130	protein coding gene	Chr2:154655872-154664969 (+)
PWK/PhJ	MGP_PWKPhJ_G0025564	protein coding gene	Chr2:149131112-149136879 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025367	protein coding gene	Chr2:153495777-153501635 (+)
WSB/EiJ	MGP_WSBEiJ_G0025900	protein coding gene	Chr2:155585890-155593038 (+)

Human Ortholog

SRXN1, sulfiredoxin 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRXN1, sulfiredoxin 1
Synonyms

C20orf139, Npn3, SRX, SRX1
Links

HGNC:16132

NCBI Gene ID: 140809

neXtProt AC: NX_Q9BYN0

UniProt: Q9BYN0
Chr Location

20p13; chr20:646615-653200 (-) GRCh38

MGI Vertebrate Homology

Srxn1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: SRXN1
Protein SuperFamily

Sulfiredoxin
Gene Tree

Srxn1

less

Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Srxn1
Incidental Mutations

CvDC
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased sensitivity to LPS-induced shock.

less

All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

2
cDNA Data

56
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

45
RefSeq

4
UniProt

4
CCDS

CCDS16877.2

Ensembl

ENSMUSG00000032802 (Evidence)
NCBI Gene

76650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032802	Ensembl Gene Model \| MGI Sequence Detail	5861	C57BL/6J	± kb
transcript	ENSMUST00000041500	Ensembl \| MGI Sequence Detail	2812	Not Applicable
polypeptide	ENSMUSP00000046196	Ensembl \| MGI Sequence Detail	155	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000015642 sulfiredoxin-1

(term hierarchy)
EC

1.8.98.2
InterPro Domains

IPR003115 ParB/Sulfiredoxin

IPR036086 ParB/Sulfiredoxin superfamily

IPR016692 Sulfiredoxin

less

All nucleic 57

cDNA 56

Primer pair 1

Microarray probesets 6

less

MGD-MRK-31044, MGI:1923900, MGI:2139100, MGI:2139350

Summaries

All 57

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 17
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:327984 Rius-Perez S, et al., p53 drives necroptosis via downregulation of sulfiredoxin and peroxiredoxin 3. Redox Biol. 2022 Aug 20;56:102423

TSS for Srxn1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20767	Chr2:151946722-151946738 (+)	-706 bp
Tssr20768	Chr2:151946834-151946855 (+)	-591 bp
Tssr20769	Chr2:151947642-151947659 (+)	215 bp
Tssr20770	Chr2:151948176-151948182 (+)	743 bp
Tssr20771	Chr2:151949933-151949942 (+)	2,502 bp
Tssr20772	Chr2:151950983-151950999 (+)	3,555 bp
Tssr20773	Chr2:151951289-151951301 (+)	3,859 bp
Tssr20774	Chr2:151952751-151952758 (+)	5,319 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24