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Il1rap Gene Detail
Summary
  • Symbol
    Il1rap
  • Name
    interleukin 1 receptor accessory protein
  • Synonyms
    6430709H04Rik, IL-1R AcP, IL-1RAcP
  • Feature Type
    protein coding gene
  • IDs
    MGI:104975
    NCBI Gene: 16180
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:26400454-26548867 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 18.21 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4596 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104975
 protein coding gene Chr16:26400259-26548878 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022696
 protein coding gene Chr16:24324128-24473928 (+)
A/J MGP_AJ_G0022658
 protein coding gene Chr16:23180397-23327516 (+)
AKR/J MGP_AKRJ_G0022632
 protein coding gene Chr16:24125977-24274288 (+)
BALB/cJ MGP_BALBcJ_G0022663
 protein coding gene Chr16:23381415-23528814 (+)
C3H/HeJ MGP_C3HHeJ_G0022427
 protein coding gene Chr16:24218614-24364376 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023112
 protein coding gene Chr16:24848850-24991859 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020630
 protein coding gene Chr16:23741569-23885893 (+)
CAST/EiJ MGP_CASTEiJ_G0021956
 protein coding gene Chr16:24260265-24408868 (+)
CBA/J MGP_CBAJ_G0022398
 protein coding gene Chr16:25922868-26090569 (+)
DBA/2J MGP_DBA2J_G0022530
 protein coding gene Chr16:23120839-23268084 (+)
FVB/NJ MGP_FVBNJ_G0022506
 protein coding gene Chr16:23103789-23251643 (+)
LP/J MGP_LPJ_G0022598
 protein coding gene Chr16:24103888-24260645 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022525
 protein coding gene Chr16:25342511-25497681 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023124
 protein coding gene Chr16:24077498-24228338 (+)
PWK/PhJ MGP_PWKPhJ_G0021695
 protein coding gene Chr16:23410572-23557922 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021526
 protein coding gene Chr16:23828630-23977057 (+)
WSB/EiJ MGP_WSBEiJ_G0022000
 protein coding gene Chr16:24009741-24161569 (+)



Homology
more
  • Human Ortholog
    IL1RAP, interleukin 1 receptor accessory protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL1RAP, interleukin 1 receptor accessory protein
  • Synonyms
    C3orf13, IL1R3, IL-1RAcP
  • Links
    NCBI Gene ID: 3556
    neXtProt AC: NX_Q9NPH3
    UniProt: Q9NPH3

  • Chr Location
    3q28; chr3:190514051-190659750 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and grossly normal but show no biological response to IL-1.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    46
  • cDNA Data
    64
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022514 Ensembl Gene Model | MGI Sequence Detail 148414 C57BL/6J ±  kb
transcript ENSMUST00000096129 Ensembl | MGI Sequence Detail 4438 Not Applicable  
polypeptide ENSMUSP00000093843 Ensembl | MGI Sequence Detail 685 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 67
    cDNA 65
    Primer pair 1
    Other 1

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-31048, MGI:2146394, MGI:2146602, MGI:2441718
References
more
  • Summaries
    All 76
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 28
  • Earliest
    J:25951 Greenfeder SA, et al., Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem. 1995 Jun 9;270(23):13757-65
  • Latest
    J:355217 Lee Y, et al., Sleep loss-induced oncogenic pathways are mediated via the neuron-specific interleukin-1 receptor accessory protein (AcPb). Brain Behav Immun. 2024 Sep 28;123:411-421
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory