Mxd3 MGI Mouse Gene Detail - MGI:104987 - Max dimerization protein 3

Symbol

Mxd3
Name

Max dimerization protein 3
Synonyms

4631412E13Rik, bHLHc13, Mad3

Feature Type

protein coding gene
IDs

MGI:104987
NCBI Gene: 17121
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:55472981-55477636 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM
Mapping Data

4 experiments

SNPs within 2kb

173 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104987	protein coding gene	Chr13:55472981-55477937 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020591	protein coding gene	Chr13:54795336-54799920 (-)
A/J	MGP_AJ_G0020545	protein coding gene	Chr13:52773668-52778254 (-)
AKR/J	MGP_AKRJ_G0020523	protein coding gene	Chr13:54329269-54333766 (-)
BALB/cJ	MGP_BALBcJ_G0020541	protein coding gene	Chr13:53003144-53007828 (-)
C3H/HeJ	MGP_C3HHeJ_G0020340	protein coding gene	Chr13:54144442-54149504 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020975	protein coding gene	Chr13:56449722-56454319 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018557	protein coding gene	Chr13:50723728-50727931 (-)
CAST/EiJ	MGP_CASTEiJ_G0019854	protein coding gene	Chr13:54239780-54244815 (-)
CBA/J	MGP_CBAJ_G0020300	protein coding gene	Chr13:58607398-58612127 (-)
DBA/2J	MGP_DBA2J_G0020423	protein coding gene	Chr13:52324989-52329655 (-)
FVB/NJ	MGP_FVBNJ_G0020402	protein coding gene	Chr13:51796330-51800532 (-)
LP/J	MGP_LPJ_G0020499	protein coding gene	Chr13:55057870-55062633 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020431	protein coding gene	Chr13:58088799-58094063 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021018	protein coding gene	Chr13:53918250-53922834 (-)
PWK/PhJ	MGP_PWKPhJ_G0019610	protein coding gene	Chr13:52353944-52358953 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019437	protein coding gene	Chr13:52834534-52840710 (-)
WSB/EiJ	MGP_WSBEiJ_G0019916	protein coding gene	Chr13:54270644-54275371 (-)

Human Ortholog

MXD3, MAX dimerization protein 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MXD3, MAX dimerization protein 3
Synonyms

BHLHC13, MAD3, MYX
Links

HGNC:14008

NCBI Gene ID: 83463

neXtProt AC: NX_Q9BW11

UniProt: Q9BW11
Chr Location

5q35.3; chr5:177301461-177312757 (-) GRCh38

MGI Vertebrate Homology

Mxd3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MXD3
Gene Tree

Mxd3

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

11
Targeted

3
Genomic Mutations

2 involving Mxd3
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

11 strains or lines available

Mice homozygous for disruptions in this gene have an essentially normal phenotype. The show an increased sensitivity to gamma irradiation.

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All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

960
Tissues

156
cDNA Data

34
Literature Summary

17

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mxd3

ZFIN mxd3

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All Sequences

35
RefSeq

3
UniProt

1
CCDS

CCDS26543.1

Ensembl

ENSMUSG00000021485 (Evidence)
NCBI Gene

17121

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021485	Ensembl Gene Model \| MGI Sequence Detail	4656	C57BL/6J	± kb
transcript	ENSMUST00000021941	Ensembl \| MGI Sequence Detail	1327	Not Applicable
polypeptide	ENSMUSP00000021941	Ensembl \| MGI Sequence Detail	206	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010791 max dimerization protein 3

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 40

cDNA 36

Primer pair 3

Other 1

Microarray probesets 5

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MGD-MRK-31060, MGI:2148234

Summaries

All 55

Developmental Gene Expression 17

Diseases 1

Gene Ontology 4

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mxd3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122684	Chr13:55477536-55477589 (-)	73 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24