Crybb1 Gene Detail

Summary

• Symbol
  Crybb1
• Name
  crystallin, beta B1
• Synonyms
  3110006K12Rik

• Feature Type
  protein coding gene
• IDs
  MGI:104992
  NCBI Gene: 12960
• Alliance
  gene page
• Transcription Start Sites
  33 TSS

Location &
Maps

• Sequence Map
  Chr5:112403686-112417451 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 5, 54.63 cM
• Mapping Data
  4 experiments

Strain
Comparison

• SNPs within 2kb
  439 from dbSNP Build 142
• Strain Annotations
  18
• RFLP
  2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104992	protein coding gene	Chr5:112403681-112417451 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029901	protein coding gene	Chr5:114828812-114842848 (+)
A/J	MGP_AJ_G0029867	protein coding gene	Chr5:110358108-110371941 (+)
AKR/J	MGP_AKRJ_G0029805	protein coding gene	Chr5:113865090-113878865 (+)
BALB/cJ	MGP_BALBcJ_G0029878	protein coding gene	Chr5:111717143-111730885 (+)
C3H/HeJ	MGP_C3HHeJ_G0029598	protein coding gene	Chr5:114304700-114319768 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030331	protein coding gene	Chr5:119314264-119330381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027560	protein coding gene	Chr5:105181883-105195854 (+)
CAST/EiJ	MGP_CASTEiJ_G0029006	protein coding gene	Chr5:113205834-113219847 (+)
CBA/J	MGP_CBAJ_G0029565	protein coding gene	Chr5:123790928-123804633 (+)
DBA/2J	MGP_DBA2J_G0029715	protein coding gene	Chr5:110424330-110438007 (+)
FVB/NJ	MGP_FVBNJ_G0029672	protein coding gene	Chr5:109146746-109160829 (+)
LP/J	MGP_LPJ_G0029803	protein coding gene	Chr5:115396910-115410640 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029703	protein coding gene	Chr5:128370658-128385254 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030372	protein coding gene	Chr5:113299412-113313200 (+)
PWK/PhJ	MGP_PWKPhJ_G0028720	protein coding gene	Chr5:109032809-109046837 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028558	protein coding gene	Chr5:110783260-110797930 (+)
WSB/EiJ	MGP_WSBEiJ_G0029082	protein coding gene	Chr5:113812358-113826106 (+)

Homology

• Human Ortholog
  CRYBB1, crystallin beta B1

• Vertebrate Orthologs
  3

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  CRYBB1, crystallin beta B1
  
• Synonyms
  CATCN3, CTRCT17
• Links
  HGNC:2397

  NCBI Gene ID: 1414

  neXtProt AC: NX_P53674

  UniProt: P53674

  
  
• Chr Location
  22q12.1; chr22:26599278-26618027 (-)  GRCh38

---

• MGI Vertebrate Homology
  Crybb1 stringent orthology
  1 human;1 mouse;1 rat;1 zebrafish
  
• HCOP
  vertebrate homology predictions: CRYBB1
• Gene Tree
  Crybb1
  

Human Diseases

• Diseases
  2 with human CRYBB1 associations

				Human Disease	Mouse Models
				cataract IDs cataract       DOID:83 ICD10CM:H26 ICD9CM:366.8 OMIM:601371 OMIM:PS116200 UMLS_CUI:C0029531
				cataract 17 multiple types IDs cataract 17 multiple types       DOID:0110270 ICD10CM:Q12.0 OMIM:611544

Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  12 phenotype references
  

• All Mutations and Alleles
  19
• Chemically induced (other)
  1
• Endonuclease-mediated
  6
• Gene trapped
  11
• Radiation induced
  1
• Genomic Mutations
  2 involving Crybb1
• Incidental Mutations
  CvDC
• Find Mice (IMSR)
  10 strains or lines available
• Recombinase Activity
  Comparison Matrix Gene Expression + Recombinase Activity

Gene Ontology
(GO)
Classifications

• All GO Annotations
  7
• GO References
  5

Expression

• Assay Results
  747
• Tissues
  14
• cDNA Data
  306
• Literature Summary
  20

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase crybb1
  ZFIN crybb1

Sequences &
Gene Models

• All Sequences
  51
• RefSeq
  10
• UniProt
  3
• CCDS
  CCDS19537.1

• Ensembl
  ENSMUSG00000029343 (Evidence)
• NCBI Gene
  12960

Representative Sequences			Length	Strain/Species
genomic	12960	NCBI Gene Model | MGI Sequence Detail	13766	C57BL/6J
transcript	NM_001312894	RefSeq | MGI Sequence Detail	990	ZRU/MplStud
polypeptide	Q9WVJ5	UniProt | EBI | MGI Sequence Detail	250	Not Applicable

Protein
Information

• UniProt
  3 Sequences
• Protein Ontology
  PR:000005911 beta-crystallin B1
  (term hierarchy)
• PDB
  8H0R
• InterPro Domains
  IPR001064 Beta/gamma crystallin
  IPR050252 Beta/Gamma-Crystallin
  IPR011024 Gamma-crystallin-like

Molecular
Reagents

• All nucleic 312

  Genomic 3

  cDNA 306

  Primer pair 3

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-31065, MGI:1920360

References

• Summaries
  All 63

  Developmental Gene Expression 20

  Gene Ontology 5

  Phenotypes 12
• Earliest
  J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
• Latest
  J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crybb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr47954	Chr5:112403679-112403693 (+)	0 bp
Tssr47955	Chr5:112405329-112405340 (+)	1,649 bp
Tssr1592	Chr5:112405346-112405356 (+)	1,665 bp
Tssr47956	Chr5:112405435-112405448 (+)	1,756 bp
Tssr47957	Chr5:112407172-112407183 (+)	3,492 bp
Tssr47958	Chr5:112407188-112407203 (+)	3,510 bp
Tssr47959	Chr5:112407347-112407365 (+)	3,670 bp
Tssr47960	Chr5:112407491-112407525 (+)	3,822 bp
Tssr47961	Chr5:112409451-112409462 (+)	5,771 bp
Tssr47962	Chr5:112409482-112409502 (+)	5,806 bp
Tssr47963	Chr5:112409508-112409519 (+)	5,828 bp
Tssr47964	Chr5:112409539-112409547 (+)	5,857 bp
Tssr47965	Chr5:112409548-112409556 (+)	5,866 bp
Tssr47966	Chr5:112409575-112409587 (+)	5,895 bp
Tssr47967	Chr5:112409590-112409601 (+)	5,910 bp
Tssr47968	Chr5:112409607-112409612 (+)	5,924 bp
Tssr47969	Chr5:112409657-112409666 (+)	5,976 bp
Tssr47970	Chr5:112409668-112409719 (+)	6,008 bp
Tssr47971	Chr5:112409748-112409759 (+)	6,068 bp
Tssr47972	Chr5:112409764-112409773 (+)	6,083 bp
Tssr47973	Chr5:112409809-112409840 (+)	6,139 bp
Tssr47974	Chr5:112409848-112409889 (+)	6,183 bp
Tssr47975	Chr5:112409893-112409912 (+)	6,217 bp
Tssr47976	Chr5:112411381-112411392 (+)	7,701 bp
Tssr47977	Chr5:112411426-112411441 (+)	7,748 bp
Tssr47978	Chr5:112415384-112415391 (+)	11,702 bp
Tssr47979	Chr5:112415410-112415423 (+)	11,731 bp
Tssr47980	Chr5:112417176-112417184 (+)	13,494 bp
Tssr47981	Chr5:112417323-112417330 (+)	13,641 bp
Tssr47982	Chr5:112417340-112417348 (+)	13,658 bp
Tssr47983	Chr5:112417354-112417362 (+)	13,672 bp
Tssr47984	Chr5:112417363-112417372 (+)	13,682 bp
Tssr47985	Chr5:112417374-112417411 (+)	13,707 bp