Ddx5 MGI Mouse Gene Detail - MGI:105037

Symbol

Ddx5
Name

DEAD box helicase 5
Synonyms

2600009A06Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 5, Hlr1, p68

Feature Type

protein coding gene
IDs

MGI:105037
NCBI Gene: 13207
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr11:106671181-106680011 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 70.01 cM, cytoband E2
Mapping Data

5 experiments

SNPs within 2kb

175 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105037	protein coding gene	Chr11:106671181-106680011 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019313	protein coding gene	Chr11:110115267-110126015 (-)
A/J	MGP_AJ_G0019281	protein coding gene	Chr11:105412400-105421990 (-)
AKR/J	MGP_AKRJ_G0019250	protein coding gene	Chr11:108555653-108564270 (-)
BALB/cJ	MGP_BALBcJ_G0019255	protein coding gene	Chr11:105827279-105838053 (-)
C3H/HeJ	MGP_C3HHeJ_G0019064	protein coding gene	Chr11:108850399-108859637 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019705	protein coding gene	Chr11:113516131-113526730 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017329	protein coding gene	Chr11:102684730-102689858 (-)
CAST/EiJ	MGP_CASTEiJ_G0018617	protein coding gene	Chr11:109938909-109946931 (-)
CBA/J	MGP_CBAJ_G0019033	protein coding gene	Chr11:118219231-118228259 (-)
DBA/2J	MGP_DBA2J_G0019145	protein coding gene	Chr11:104881815-104891555 (-)
FVB/NJ	MGP_FVBNJ_G0019136	protein coding gene	Chr11:104397173-104405675 (-)
LP/J	MGP_LPJ_G0019215	protein coding gene	Chr11:110565127-110574075 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019166	protein coding gene	Chr11:117459404-117470176 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019742	protein coding gene	Chr11:109073737-109084042 (-)
PWK/PhJ	MGP_PWKPhJ_G0018382	protein coding gene	Chr11:105997818-106006910 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018173	protein coding gene	Chr11:108847728-108857435 (-)
WSB/EiJ	MGP_WSBEiJ_G0018668	protein coding gene	Chr11:109050111-109059696 (-)

Human Ortholog

DDX5, DEAD-box helicase 5

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DDX5, DEAD-box helicase 5
Synonyms

G17P1, HLR1, HUMP68, p68
Links

HGNC:2746

NCBI Gene ID: 1655

neXtProt AC: NX_P17844

UniProt: P17844
Chr Location

17q23.3; chr17:64498254-64508199 (-) GRCh38

MGI Vertebrate Homology

Ddx5 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DDX5
Gene Tree

Ddx5

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Phenotype Summary

10 phenotypes from 1 allele in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

1
Gene trapped

23
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

39 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter/null allele die around E11.5 displaying blood vessel malformations.

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All GO Annotations

89
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

808
Tissues

100
cDNA Data

27
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ddx5

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All Sequences

82
RefSeq

6
UniProt

12
CCDS

CCDS25562.1

Ensembl

ENSMUSG00000020719 (Evidence)
NCBI Gene

13207

			Length	Strain/Species	Flank
genomic	13207	NCBI Gene Model \| MGI Sequence Detail	8831	C57BL/6J	± kb
transcript	NM_001355676	RefSeq \| MGI Sequence Detail	3719	Not Specified
polypeptide	Q61656	UniProt \| EBI \| MGI Sequence Detail	614	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000029396 probable ATP-dependent RNA helicase DDX5

(term hierarchy)
EC

3.6.4.13
InterPro Domains

IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site

IPR011545 DEAD/DEAH box helicase domain

IPR001650 Helicase, C-terminal domain-like

IPR014001 Helicase superfamily 1/2, ATP-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR014014 RNA helicase, DEAD-box type, Q motif

IPR012587 RNA helicase p68 repeat
GlyGen

Q61656 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 30

cDNA 28

Primer pair 1

Other 1

Microarray probesets 7

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MGD-MRK-16216, MGD-MRK-32076, MGI:1919368

Summaries

All 89

Developmental Gene Expression 10

Gene Ontology 19

Phenotypes 18
Earliest

J:9938 Iggo R, et al., Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Aug;86(16):6211-4
Latest

J:351707 Wen C, et al., MCM8 interacts with DDX5 to promote R-loop resolution. EMBO J. 2024 Jul;43(14):3044-3071

TSS for Ddx5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr111418	Chr11:106680262-106680280 (-)	-260 bp
Tssr111417	Chr11:106679983-106680018 (-)	10 bp
Tssr111416	Chr11:106679961-106679978 (-)	41 bp
Tssr111415	Chr11:106679941-106679959 (-)	61 bp
Tssr111414	Chr11:106679909-106679935 (-)	89 bp
Tssr111413	Chr11:106679742-106679755 (-)	262 bp
Tssr111412	Chr11:106679727-106679739 (-)	278 bp
Tssr111411	Chr11:106679671-106679708 (-)	321 bp
Tssr111410	Chr11:106679468-106679475 (-)	539 bp
Tssr111409	Chr11:106679312-106679326 (-)	692 bp
Tssr111408	Chr11:106678886-106678889 (-)	1,123 bp
Tssr111407	Chr11:106678371-106678401 (-)	1,625 bp
Tssr111406	Chr11:106677544-106677593 (-)	2,442 bp
Tssr111400	Chr11:106672938-106672943 (-)	7,070 bp
Tssr111399	Chr11:106672710-106672725 (-)	7,293 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24