About   Help   FAQ
Ahr Gene Detail
Summary
  • Symbol
    Ahr
  • Name
    aryl-hydrocarbon receptor
  • Synonyms
    Ah, Ahh, Ahre, bHLHe76, dioxin receptor, In
  • Feature Type
    protein coding gene
  • IDs
    MGI:105043
    NCBI Gene: 11622
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:35547978-35584988 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 15.78 cM
  • Mapping Data
    37 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1240 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105043
 protein coding gene Chr12:35547973-35585037 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019684
 protein coding gene Chr12:33704146-33739715 (-)
A/J MGP_AJ_G0019650
 protein coding gene Chr12:32653614-32690786 (-)
AKR/J MGP_AKRJ_G0019621
 protein coding gene Chr12:33679101-33714583 (-)
BALB/cJ MGP_BALBcJ_G0019628
 protein coding gene Chr12:32854836-32890748 (-)
C3H/HeJ MGP_C3HHeJ_G0019432
 protein coding gene Chr12:33593828-33630332 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020075
 protein coding gene Chr12:34648560-34688914 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017700
 protein coding gene Chr12:31790715-31822696 (-)
CAST/EiJ MGP_CASTEiJ_G0018986
 protein coding gene Chr12:28659191-28696008 (-)
CBA/J MGP_CBAJ_G0019404
 protein coding gene Chr12:35800254-35838163 (-)
DBA/2J MGP_DBA2J_G0019517
 protein coding gene Chr12:32500547-32536239 (-)
FVB/NJ MGP_FVBNJ_G0019506
 protein coding gene Chr12:32225792-32264124 (-)
LP/J MGP_LPJ_G0019587
 protein coding gene Chr12:33777886-33816155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019542
 protein coding gene Chr12:35467603-35515249 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020115
 protein coding gene Chr12:33185712-33222388 (-)
PWK/PhJ MGP_PWKPhJ_G0018753
 protein coding gene Chr12:27194283-27230508 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018542
 protein coding gene Chr12:27808596-27846055 (-)
WSB/EiJ MGP_WSBEiJ_G0019036
 protein coding gene Chr12:33433057-33468926 (-)



Homology
more
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AHR, aryl hydrocarbon receptor
  • Synonyms
    bHLHe76, FVH3, RP85
  • Links
    NCBI Gene ID: 196
    neXtProt AC: NX_P35869
    UniProt: P35869

  • Chr Location
    7p21.1; chr7:16916359-17346152 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ahr mouse models; 1 with human AHR associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    145 phenotypes from 12 alleles in 27 genetic backgrounds
    10 phenotypes from multigenic genotypes
    8 images
    440 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities. Conditional homozygous KO in the retina leads to retinal degeneration. Conditional KO in neural progenitor cells leads to decreased susceptibility to ischemic brain injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    133
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1079
  • Tissues
    244
  • cDNA Data
    74
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11622 NCBI Gene Model | MGI Sequence Detail 37011 C57BL/6J ±  kb
    transcript NM_013464 RefSeq | MGI Sequence Detail 5494 ZRU/MplStud  
    polypeptide Q8R4S5 UniProt | EBI | MGI Sequence Detail 883 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 10
      cDNA 75
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11402, MGD-MRK-1198, MGD-MRK-1219, MGD-MRK-32082, MGI:895073
    References
    more
    • Summaries
      All 713
      Developmental Gene Expression 28
      Diseases 2
      Gene Ontology 37
      Phenotypes 440
    • Earliest
      J:84245 Poel WE, et al., Comparative susceptibilities of seven inbred strains of mice to qualified applications of 3, 4-benzpyrene. Proc Am Assoc Cancer Res. 1958;2:335 (Abstr.)
    • Latest
      J:357723 Sirbulescu RF, et al., Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis. FASEB J. 2024 Jul 15;38(13):e23796
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory