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Cyp2a12 Gene Detail
Summary
  • Symbol
    Cyp2a12
  • Name
    cytochrome P450, family 2, subfamily a, polypeptide 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:105055
    NCBI Gene: 13085
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:26728515-26736243 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.77 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    436 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105055
 protein coding gene Chr7:26728506-26736800 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031893
 protein coding gene Chr7:25522497-25531294 (-)
A/J MGP_AJ_G0031872
 protein coding gene Chr7:25032423-25040310 (+)
AKR/J MGP_AKRJ_G0031803
 protein coding gene Chr7:25699721-25711043 (+)
BALB/cJ MGP_BALBcJ_G0031877
 protein coding gene Chr7:25199132-25207560 (+)
C3H/HeJ MGP_C3HHeJ_G0031600
 protein coding gene Chr7:26044277-26053002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032341
 protein coding gene Chr7:26480772-26489066 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0031565
 protein coding gene Chr7:27600332-27614556 (+)
DBA/2J MGP_DBA2J_G0031717
 protein coding gene Chr7:24836496-24844278 (+)
FVB/NJ MGP_FVBNJ_G0031671
 protein coding gene Chr7:24898592-24913103 (+)
LP/J MGP_LPJ_G0031797
 protein coding gene Chr7:25941056-25950641 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031708
 protein coding gene Chr7:27257000-27264965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032374
 protein coding gene Chr7:25219576-25228237 (+)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0030493
 protein coding gene Chr7:16197274-16205004 (+)
WSB/EiJ MGP_WSBEiJ_G0031043
 protein coding gene Chr7:25488548-25496290 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    812
  • Tissues
    106
  • cDNA Data
    50
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13085 NCBI Gene Model | MGI Sequence Detail 7729 C57BL/6J ±  kb
transcript NM_133657 RefSeq | MGI Sequence Detail 1675 FVB/N  
polypeptide P56593 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 50
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-32094
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 3
  • Earliest
    J:23304 Iwasaki M, et al., Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction. Biochem J. 1993 Apr 15;291(Pt 2):569-73
  • Latest
    J:302190 Honda A, et al., Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition. J Lipid Res. 2020 Jan;61(1):54-69
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory