Rab24 MGI Mouse Gene Detail - MGI:105065 - RAB24, member RAS oncogene family

Symbol

Rab24
Name

RAB24, member RAS oncogene family
Synonyms

6530406O07Rik

Feature Type

protein coding gene
IDs

MGI:105065
NCBI Gene: 19336
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr13:55467556-55469759 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 29.80 cM
Mapping Data

4 experiments

SNPs within 2kb

101 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105065	protein coding gene	Chr13:55467036-55469807 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020589	protein coding gene	Chr13:54787897-54790654 (-)
A/J	MGP_AJ_G0020543	protein coding gene	Chr13:52767723-52770480 (-)
AKR/J	MGP_AKRJ_G0020521	protein coding gene	Chr13:54323324-54326081 (-)
BALB/cJ	MGP_BALBcJ_G0020539	protein coding gene	Chr13:52995173-52997930 (-)
C3H/HeJ	MGP_C3HHeJ_G0020338	protein coding gene	Chr13:54138497-54141254 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020973	protein coding gene	Chr13:56443350-56446107 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018555	protein coding gene	Chr13:50717419-50720364 (-)
CAST/EiJ	MGP_CASTEiJ_G0019852	protein coding gene	Chr13:54228102-54230877 (-)
CBA/J	MGP_CBAJ_G0020298	protein coding gene	Chr13:58601329-58604086 (-)
DBA/2J	MGP_DBA2J_G0020421	protein coding gene	Chr13:52314670-52317427 (-)
FVB/NJ	MGP_FVBNJ_G0020400	protein coding gene	Chr13:51790385-51793142 (-)
LP/J	MGP_LPJ_G0020497	protein coding gene	Chr13:55051925-55054682 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020429	protein coding gene	Chr13:58082854-58085611 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021016	protein coding gene	Chr13:53910398-53913155 (-)
PWK/PhJ	MGP_PWKPhJ_G0019608	protein coding gene	Chr13:52339634-52342408 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019435	protein coding gene	Chr13:52826579-52829293 (-)
WSB/EiJ	MGP_WSBEiJ_G0019914	protein coding gene	Chr13:54264688-54267445 (-)

Human Ortholog

RAB24, RAB24, member RAS oncogene family

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB24, RAB24, member RAS oncogene family
Links

HGNC:9765

NCBI Gene ID: 53917

neXtProt AC: NX_Q969Q5

UniProt: Q969Q5
Chr Location

5q35.3; chr5:177301198-177303744 (-) GRCh38

MGI Vertebrate Homology

Rab24 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: RAB24
Gene Tree

Rab24

Diseases

1 with human RAB24 associations

				Human Disease	Mouse Models
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

2
Targeted

4
Genomic Mutations

2 involving Rab24
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

778
Tissues

44
cDNA Data

95
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab24

ZFIN rab24

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All Sequences

72
RefSeq

24
UniProt

4
CCDS

CCDS26541.1

Ensembl

ENSMUSG00000034789 (Evidence)
NCBI Gene

19336

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034789	Ensembl Gene Model \| MGI Sequence Detail	2204	C57BL/6J	± kb
transcript	ENSMUST00000035242	Ensembl \| MGI Sequence Detail	1168	Not Applicable
polypeptide	ENSMUSP00000046188	Ensembl \| MGI Sequence Detail	203	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013597 Ras-related protein Rab-24

(term hierarchy)
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041828 Rab24

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain

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All nucleic 96

cDNA 96

Microarray probesets 4

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MGD-MRK-32104, MGI:1915043

Summaries

All 49

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 16
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab24:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122683	Chr13:55469741-55469787 (-)	-5 bp
Tssr122682	Chr13:55469710-55469724 (-)	42 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24