Rab4a MGI Mouse Gene Detail - MGI:105069 - RAB4A, member RAS oncogene family

Symbol

Rab4a
Name

RAB4A, member RAS oncogene family
Synonyms

Rab4

Feature Type

protein coding gene
IDs

MGI:105069
NCBI Gene: 19341
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr8:124532748-124562030 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 72.19 cM
Mapping Data

2 experiments

SNPs within 2kb

1109 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105069	protein coding gene	Chr8:124532724-124562030 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034261	protein coding gene	Chr8:127440943-127469528 (+)
A/J	MGP_AJ_G0034241	protein coding gene	Chr8:122186000-122216047 (+)
AKR/J	MGP_AKRJ_G0034168	protein coding gene	Chr8:125696820-125726119 (+)
BALB/cJ	MGP_BALBcJ_G0034234	protein coding gene	Chr8:122372962-122402379 (+)
C3H/HeJ	MGP_C3HHeJ_G0033945	protein coding gene	Chr8:126335390-126364498 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034754	protein coding gene	Chr8:131717714-131747958 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031696	protein coding gene	Chr8:114965115-114993530 (+)
CAST/EiJ	MGP_CASTEiJ_G0033273	protein coding gene	Chr8:126443808-126476259 (+)
CBA/J	MGP_CBAJ_G0033918	protein coding gene	Chr8:136532701-136565488 (+)
DBA/2J	MGP_DBA2J_G0034074	protein coding gene	Chr8:121337803-121369413 (+)
FVB/NJ	MGP_FVBNJ_G0034018	protein coding gene	Chr8:120501971-120531444 (+)
LP/J	MGP_LPJ_G0034164	protein coding gene	Chr8:127603390-127631952 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034065	protein coding gene	Chr8:138674041-138704048 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034773	protein coding gene	Chr8:125926853-125960449 (+)
PWK/PhJ	MGP_PWKPhJ_G0032974	protein coding gene	Chr8:121094187-121124306 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032814	protein coding gene	Chr8:124573989-124604826 (+)
WSB/EiJ	MGP_WSBEiJ_G0033389	protein coding gene	Chr8:126655587-126688089 (+)

Human Ortholog

RAB4A, RAB4A, member RAS oncogene family

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB4A, RAB4A, member RAS oncogene family
Synonyms

HRES-1, HRES1, HRES-1/RAB4, RAB4
Links

HGNC:9781

NCBI Gene ID: 5867

neXtProt AC: NX_P20338

UniProt: P20338
Chr Location

1q42.13; chr1:229271062-229305894 (+) GRCh38

MGI Vertebrate Homology

Rab4a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RAB4A
Gene Tree

Rab4a

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

47
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

44
cDNA Data

57
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN rab4a

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All Sequences

44
RefSeq

3
UniProt

4
CCDS

CCDS52703.1

Ensembl

ENSMUSG00000019478 (Evidence)
NCBI Gene

19341

			Length	Strain/Species	Flank
genomic	19341	NCBI Gene Model \| MGI Sequence Detail	29283	C57BL/6J	± kb
transcript	NM_009003	RefSeq \| MGI Sequence Detail	1399	C57BL/6
polypeptide	P56371	UniProt \| EBI \| MGI Sequence Detail	218	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013631 Ras-related protein Rab-4A

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR041819 Rab4

IPR050209 Rab GTPases family involved in membrane trafficking

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain
GlyGen

P56371 1 site, 1 N-linked glycan (1 site)

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All nucleic 58

cDNA 58

Microarray probesets 4

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MGD-MRK-32108, MGI:2142629

Summaries

All 55

Developmental Gene Expression 8

Gene Ontology 12

Phenotypes 8
Earliest

J:30578 Barbosa MD, et al., The Rab protein family: genetic mapping of six Rab genes in the mouse. Genomics. 1995 Dec 10;30(3):439-44
Latest

J:346995 Huang N, et al., Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. Nat Commun. 2024 Mar 22;15(1):2598

TSS for Rab4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr79988	Chr8:124532587-124532604 (+)	-152 bp
Tssr79989	Chr8:124532625-124532634 (+)	-118 bp
Tssr79990	Chr8:124532699-124532729 (+)	-34 bp
Tssr79991	Chr8:124532731-124532776 (+)	6 bp
Tssr79992	Chr8:124532781-124532802 (+)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24