Tnni1 MGI Mouse Gene Detail - MGI:105073 - troponin I, skeletal, slow 1

Symbol

Tnni1
Name

troponin I, skeletal, slow 1
Synonyms

2700018B22Rik, ssTnI

Feature Type

protein coding gene
IDs

MGI:105073
NCBI Gene: 21952
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr1:135709252-135738727 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 59.28 cM
Mapping Data

5 experiments

SNPs within 2kb

1103 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105073	protein coding gene	Chr1:135707172-135738727 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016528	protein coding gene	Chr1:139562138-139596713 (+)
A/J	MGP_AJ_G0016511	protein coding gene	Chr1:134283698-134315350 (+)
AKR/J	MGP_AKRJ_G0016476	protein coding gene	Chr1:138275953-138310313 (+)
BALB/cJ	MGP_BALBcJ_G0016471	protein coding gene	Chr1:134603859-134635184 (+)
C3H/HeJ	MGP_C3HHeJ_G0016297	protein coding gene	Chr1:138377519-138410405 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016932	protein coding gene	Chr1:144591652-144624948 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014643	protein coding gene	Chr1:127387387-127419893 (+)
CAST/EiJ	MGP_CASTEiJ_G0015877	protein coding gene	Chr1:137459954-137492653 (+)
CBA/J	MGP_CBAJ_G0016270	protein coding gene	Chr1:149594999-149626926 (+)
DBA/2J	MGP_DBA2J_G0016376	protein coding gene	Chr1:133277333-133308897 (+)
FVB/NJ	MGP_FVBNJ_G0016375	protein coding gene	Chr1:131923060-131955514 (+)
LP/J	MGP_LPJ_G0016447	protein coding gene	Chr1:140796111-140830228 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016400	protein coding gene	Chr1:155249354-155285870 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016968	protein coding gene	Chr1:138046785-138079422 (+)
PWK/PhJ	MGP_PWKPhJ_G0015663	protein coding gene	Chr1:132314469-132348057 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015450	protein coding gene	Chr1:137028369-137059820 (+)
WSB/EiJ	MGP_WSBEiJ_G0015940	protein coding gene	Chr1:138082112-138113782 (+)

Human Ortholog

TNNI1, troponin I1, slow skeletal type

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNNI1, troponin I1, slow skeletal type
Synonyms

SSTNI, TNN1
Links

HGNC:11945

NCBI Gene ID: 7135

neXtProt AC: NX_P19237

UniProt: P19237
Chr Location

1q32.1; chr1:201403784-201429866 (-) GRCh38

MGI Vertebrate Homology

Tnni1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TNNI1
Gene Tree

Tnni1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

2
Gene trapped

6
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Tnni1
Incidental Mutations

APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

966
Tissues

52
cDNA Data

126
Literature Summary

48

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TNNI1

Xenbase tnni1, tnni1.2

ZFIN tnni1b

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All Sequences

58
RefSeq

10
UniProt

4
CCDS

CCDS48374.1

Ensembl

ENSMUSG00000026418 (Evidence)
NCBI Gene

21952

			Length	Strain/Species	Flank
genomic	21952	NCBI Gene Model \| MGI Sequence Detail	29476	C57BL/6J	± kb
transcript	NM_021467	RefSeq \| MGI Sequence Detail	1086	ZRU/MplStud
polypeptide	Q9WUZ5	UniProt \| EBI \| MGI Sequence Detail	187	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016504 troponin I, slow skeletal muscle

(term hierarchy)
InterPro Domains

IPR001978 Troponin

IPR038077 Troponin domain superfamily

IPR050875 Troponin I

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All nucleic 138

cDNA 128

Primer pair 10

Microarray probesets 3

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MGD-MRK-32113, MGI:1917282, MGI:2138320

Summaries

All 91

Developmental Gene Expression 48

Gene Ontology 6

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:347631 Li C, et al., Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes. Adv Sci (Weinh). 2024 Mar;11(11):e2305992

TSS for Tnni1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8980	Chr1:135710871-135710881 (+)	1,624 bp
Tssr8981	Chr1:135727171-135727218 (+)	17,943 bp
Tssr8982	Chr1:135727228-135727237 (+)	17,981 bp
Tssr8983	Chr1:135727700-135727707 (+)	18,452 bp
Tssr8984	Chr1:135728566-135728577 (+)	19,320 bp
Tssr8985	Chr1:135729308-135729318 (+)	20,061 bp
Tssr8986	Chr1:135729437-135729448 (+)	20,191 bp
Tssr8987	Chr1:135738615-135738624 (+)	29,368 bp
Tssr8988	Chr1:135738626-135738631 (+)	29,377 bp
Tssr8989	Chr1:135738632-135738671 (+)	29,400 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24