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Slc1a1 Gene Detail
Summary
  • Symbol
    Slc1a1
  • Name
    solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
  • Synonyms
    D130048G10Rik, EAAC1, EAAT3, MEAAC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:105083
    NCBI Gene: 20510
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:28812535-28891360 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 23.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1981 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105083
 protein coding gene Chr19:28812449-28891360 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025012
 protein coding gene Chr19:27261867-27343031 (+)
A/J MGP_AJ_G0024989
 protein coding gene Chr19:25878839-25958351 (+)
AKR/J MGP_AKRJ_G0024957
 protein coding gene Chr19:26822796-26903809 (+)
BALB/cJ MGP_BALBcJ_G0024988
 protein coding gene Chr19:25925325-26003740 (+)
C3H/HeJ MGP_C3HHeJ_G0024744
 protein coding gene Chr19:26792912-26877506 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025429
 protein coding gene Chr19:28012853-28095424 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022848
 protein coding gene Chr19:25864344-25943742 (+)
CAST/EiJ MGP_CASTEiJ_G0024214
 protein coding gene Chr19:26618426-26702583 (+)
CBA/J MGP_CBAJ_G0024722
 protein coding gene Chr19:29345677-29434079 (+)
DBA/2J MGP_DBA2J_G0024854
 protein coding gene Chr19:25841334-25920070 (+)
FVB/NJ MGP_FVBNJ_G0024816
 protein coding gene Chr19:25689552-25769195 (+)
LP/J MGP_LPJ_G0024939
 protein coding gene Chr19:27258016-27336981 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024843
 protein coding gene Chr19:29273185-29358809 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025484
 protein coding gene Chr19:26839958-26924232 (+)
PWK/PhJ MGP_PWKPhJ_G0023962
 protein coding gene Chr19:25500844-25581515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023766
 protein coding gene Chr19:26092654-26178234 (+)
WSB/EiJ MGP_WSBEiJ_G0024281
 protein coding gene Chr19:26876808-26958830 (+)



Homology
more
  • Human Ortholog
    SLC1A1, solute carrier family 1 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC1A1, solute carrier family 1 member 1
  • Synonyms
    DCBXA, EAAC1, EAAT3, hEAAC1, SCZD18
  • Links
    NCBI Gene ID: 6505
    neXtProt AC: NX_P43005
    UniProt: P43005

  • Chr Location
    9p24.2; chr9:4490468-4587469 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Slc1a1 mouse models; 2 with human SLC1A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display reduced locomotor activity and excessive excretion of glutamate and aspartate.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    179
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1003
  • Tissues
    199
  • cDNA Data
    52
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20510 NCBI Gene Model | MGI Sequence Detail 78826 C57BL/6J ±  kb
    transcript NM_009199 RefSeq | MGI Sequence Detail 3739 C57BL/6  
    polypeptide P51906 UniProt | EBI | MGI Sequence Detail 523 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000014972 excitatory amino acid transporter 3
      (term hierarchy)
    • InterPro Domains
      IPR050746 Dicarboxylate/Amino Acid:Cation Symporter
      IPR001991 Sodium:dicarboxylate symporter
      IPR018107 Sodium:dicarboxylate symporter, conserved site
      IPR036458 Sodium:dicarboxylate symporter superfamily
    • GlyGen
      P51906 4 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 60
      cDNA 56
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-32123, MGI:2441941
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 53
      Phenotypes 51
    • Earliest
      J:47073 Swarna M, et al., Dicarboxylic aminoaciduria associated with mental retardation. Hum Genet. 1989 Jun;82(3):299-300
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory