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Rbl2 Gene Detail
Summary
  • Symbol
    Rbl2
  • Name
    RB transcriptional corepressor like 2
  • Synonyms
    p130, Rb2, retinoblastoma-like 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105085
    NCBI Gene: 19651
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:91796685-91850472 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1794 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105085
 protein coding gene Chr8:91796685-91850472 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033929
 protein coding gene Chr8:92288857-92345568 (+)
A/J MGP_AJ_G0033912
 protein coding gene Chr8:88660289-88714463 (+)
AKR/J MGP_AKRJ_G0033838
 protein coding gene Chr8:91168406-91223608 (+)
BALB/cJ MGP_BALBcJ_G0033904
 protein coding gene Chr8:88824952-88881132 (+)
C3H/HeJ MGP_C3HHeJ_G0033614
 protein coding gene Chr8:91867020-91922019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034425
 protein coding gene Chr8:95713551-95769692 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031366
 protein coding gene Chr8:82602415-82657104 (+)
CAST/EiJ MGP_CASTEiJ_G0032946
 protein coding gene Chr8:91353056-91410884 (+)
CBA/J MGP_CBAJ_G0033590
 protein coding gene Chr8:98943283-99001346 (+)
DBA/2J MGP_DBA2J_G0033744
 protein coding gene Chr8:88228761-88283673 (+)
FVB/NJ MGP_FVBNJ_G0033691
 protein coding gene Chr8:87162612-87217337 (+)
LP/J MGP_LPJ_G0033836
 protein coding gene Chr8:92407863-92464861 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033733
 protein coding gene Chr8:101360146-101417512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034443
 protein coding gene Chr8:91269440-91329073 (+)
PWK/PhJ MGP_PWKPhJ_G0032648
 protein coding gene Chr8:87535710-87592914 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032485
 protein coding gene Chr8:90138171-90195219 (+)
WSB/EiJ MGP_WSBEiJ_G0033058
 protein coding gene Chr8:91732685-91791174 (+)



Homology
more
  • Human Ortholog
    RBL2, RB transcriptional corepressor like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBL2, RB transcriptional corepressor like 2
  • Synonyms
    BRUWAG, P130, Rb2
  • Links
    NCBI Gene ID: 5934
    neXtProt AC: NX_Q08999
    UniProt: Q08999

  • Chr Location
    16q12.2; chr16:53433977-53491648 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 3 alleles in 4 genetic backgrounds
    98 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice generally show no overt phenotype. Homozygotes for a null allele show strain-dependent embryonic lethality and growth arrest associated with altered apoptosis and cell proliferation, impaired neurogenesis and myogenesis, failed embryo turning and heart looping, and thin myocardium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    121
  • cDNA Data
    17
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19651 NCBI Gene Model | MGI Sequence Detail 53788 C57BL/6J ±  kb
    transcript NM_011250 RefSeq | MGI Sequence Detail 4935 ZRU/MplStud  
    polypeptide Q64700 UniProt | EBI | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 18
      Primer pair 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32125
    References
    more
    • Summaries
      All 170
      Developmental Gene Expression 33
      Diseases 5
      Gene Ontology 11
      Phenotypes 92
    • Earliest
      J:15699 Yeung RS, et al., The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19. Oncogene. 1993 Dec;8(12):3465-8
    • Latest
      J:349755 Finlay JB, et al., Olfactory neuroblastoma mimics molecular heterogeneity and lineage trajectories of small-cell lung cancer. Cancer Cell. 2024 Jun 10;42(6):1086-1105.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory