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E2f5 Gene Detail
Summary
  • Symbol
    E2f5
  • Name
    E2F transcription factor 5
  • Synonyms
    E2F-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:105091
    NCBI Gene: 13559
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:14643701-14671369 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 3.10 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    822 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105091
 protein coding gene Chr3:14638370-14671369 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027074
 protein coding gene Chr3:11705260-11732532 (+)
A/J MGP_AJ_G0027038
 protein coding gene Chr3:11696879-11721610 (+)
AKR/J MGP_AKRJ_G0027008
 protein coding gene Chr3:11681168-11708505 (+)
BALB/cJ MGP_BALBcJ_G0027047
 protein coding gene Chr3:11433575-11458851 (+)
C3H/HeJ MGP_C3HHeJ_G0026787
 protein coding gene Chr3:12006866-12036164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027491
 protein coding gene Chr3:12506759-12532805 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024853
 protein coding gene Chr3:10026446-10049570 (+)
CAST/EiJ MGP_CASTEiJ_G0026245
 protein coding gene Chr3:12003138-12028006 (+)
CBA/J MGP_CBAJ_G0026765
 protein coding gene Chr3:12705163-12732578 (+)
DBA/2J MGP_DBA2J_G0026901
 protein coding gene Chr3:11266455-11296298 (+)
FVB/NJ MGP_FVBNJ_G0026868
 protein coding gene Chr3:11092918-11118266 (+)
LP/J MGP_LPJ_G0027011
 protein coding gene Chr3:12282774-12312217 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026889
 protein coding gene Chr3:14469783-14495249 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027551
 protein coding gene Chr3:11496550-11520855 (+)
PWK/PhJ MGP_PWKPhJ_G0025980
 protein coding gene Chr3:11381083-11408846 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025783
 protein coding gene Chr3:11549152-11572299 (+)
WSB/EiJ MGP_WSBEiJ_G0026316
 protein coding gene Chr3:11558314-11585260 (+)



Homology
more
  • Human Ortholog
    E2F5, E2F transcription factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    E2F5, E2F transcription factor 5
  • Synonyms
    E2F-5
  • Links
    NCBI Gene ID: 1875
    neXtProt AC: NX_Q15329
    UniProt: Q15329

  • Chr Location
    8q21.2; chr8:85177154-85217158 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with E2f5 mouse models; 1 with human E2F5 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop non-obstructive hydrocephalus, ruffled coats, ataxic gait, and dehydration after weaning and die prematurely at an average age of 6 weeks. They exhibit dilated ventricles and cerebral cortex atrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1026
  • Tissues
    261
  • cDNA Data
    69
  • Literature Summary
    29
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027552 Ensembl Gene Model | MGI Sequence Detail 27669 C57BL/6J ±  kb
    transcript ENSMUST00000029069 Ensembl | MGI Sequence Detail 1779 Not Applicable  
    polypeptide ENSMUSP00000029069 Ensembl | MGI Sequence Detail 335 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 69
      Primer pair 7
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32131, MGI:2139902
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 29
      Diseases 1
      Gene Ontology 12
      Phenotypes 6
    • Earliest
      J:31127 Buck V, et al., Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene. 1995 Jul 6;11(1):31-8
    • Latest
      J:314268 Akagawa R, et al., Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons. Front Cell Dev Biol. 2021;9:753175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory