About   Help   FAQ
Hpx Gene Detail
Summary
  • Symbol
    Hpx
  • Name
    hemopexin
  • Synonyms
    Hpxn, hx
  • Feature Type
    protein coding gene
  • IDs
    MGI:105112
    NCBI Gene: 15458
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105240818-105249323 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 55.91 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    333 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105112
 protein coding gene Chr7:105240818-105249344 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032756
 protein coding gene Chr7:108853379-108861498 (-)
A/J MGP_AJ_G0032736
 protein coding gene Chr7:106001068-106009969 (-)
AKR/J MGP_AKRJ_G0032669
 protein coding gene Chr7:108774492-108785582 (-)
BALB/cJ MGP_BALBcJ_G0032742
 protein coding gene Chr7:105716793-105725432 (-)
C3H/HeJ MGP_C3HHeJ_G0032451
 protein coding gene Chr7:108878841-108888807 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033247
 protein coding gene Chr7:113212777-113221025 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030231
 protein coding gene Chr7:107980266-107988366 (-)
CAST/EiJ MGP_CASTEiJ_G0031781
 protein coding gene Chr7:100706471-100716014 (-)
CBA/J MGP_CBAJ_G0032425
 protein coding gene Chr7:116967645-116976282 (-)
DBA/2J MGP_DBA2J_G0032578
 protein coding gene Chr7:104271024-104279135 (-)
FVB/NJ MGP_FVBNJ_G0032531
 protein coding gene Chr7:104077385-104085550 (-)
LP/J MGP_LPJ_G0032669
 protein coding gene Chr7:110251289-110261415 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032563
 protein coding gene Chr7:118564909-118573075 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033268
 protein coding gene Chr7:107836411-107848467 (-)
PWK/PhJ MGP_PWKPhJ_G0031494
 protein coding gene Chr7:97209910-97218504 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031343
 protein coding gene Chr7:94949993-94959675 (-)
WSB/EiJ MGP_WSBEiJ_G0031898
 protein coding gene Chr7:108482460-108491296 (-)



Homology
more
  • Human Ortholog
    HPX, hemopexin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPX, hemopexin
  • Synonyms
    HX
  • Links
    NCBI Gene ID: 3263
    neXtProt AC: NX_P02790
    UniProt: P02790

  • Chr Location
    11p15.4; chr11:6431049-6442617 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. However, they have increased susceptiblity to induced hemolytic stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    6
  • cDNA Data
    422
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15458 NCBI Gene Model | MGI Sequence Detail 8506 C57BL/6J ±  kb
    transcript NM_017371 RefSeq | MGI Sequence Detail 1489 C57BL/6  
    polypeptide Q91X72 UniProt | EBI | MGI Sequence Detail 460 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 424
      cDNA 422
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-32152
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:346943 Seika P, et al., Free heme exacerbates colonic injury induced by anti-cancer therapy. Front Immunol. 2023;14:1184105
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory