Cxcr2 MGI Mouse Gene Detail - MGI:105303 - C-X-C motif chemokine receptor 2

Symbol

Cxcr2
Name

C-X-C motif chemokine receptor 2
Synonyms

CD128, Cmkar2, Gpcr16, IL8RA, Il8rb, IL-8rb, IL-8Rh

Feature Type

protein coding gene
IDs

MGI:105303
NCBI Gene: 12765
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:74193153-74200405 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 38.41 cM
Mapping Data

17 experiments

SNPs within 2kb

291 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

8

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105303	protein coding gene	Chr1:74193150-74200405 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016141	protein coding gene	Chr1:74737830-74744647 (+)
A/J	MGP_AJ_G0016124	protein coding gene	Chr1:72120019-72127083 (+)
AKR/J	MGP_AKRJ_G0016081	protein coding gene	Chr1:74126150-74133450 (+)
BALB/cJ	MGP_BALBcJ_G0016079	protein coding gene	Chr1:72189256-72197733 (+)
C3H/HeJ	MGP_C3HHeJ_G0015910	protein coding gene	Chr1:74452826-74459767 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016532	protein coding gene	Chr1:77644794-77653407 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014253	protein coding gene	Chr1:67699565-67707564 (+)
CAST/EiJ	MGP_CASTEiJ_G0015494	protein coding gene	Chr1:73764244-73773404 (+)
CBA/J	MGP_CBAJ_G0015883	protein coding gene	Chr1:80155675-80162468 (+)
DBA/2J	MGP_DBA2J_G0015984	protein coding gene	Chr1:71453465-71460716 (+)
FVB/NJ	MGP_FVBNJ_G0015987	protein coding gene	Chr1:70629543-70637361 (+)
LP/J	MGP_LPJ_G0016056	protein coding gene	Chr1:75831015-75838705 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016007	protein coding gene	Chr1:83587922-83594615 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016579	protein coding gene	Chr1:74175127-74183033 (+)
PWK/PhJ	MGP_PWKPhJ_G0015281	protein coding gene	Chr1:70895194-70902969 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015059	protein coding gene	Chr1:73543695-73551593 (+)
WSB/EiJ	MGP_WSBEiJ_G0015556	protein coding gene	Chr1:73981051-73989238 (+)

Human Ortholog

CXCR2, C-X-C motif chemokine receptor 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CXCR2, C-X-C motif chemokine receptor 2
Synonyms

CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB, WHIMS2
Links

HGNC:6027

NCBI Gene ID: 3579

neXtProt AC: NX_P25025

UniProt: P25025
Chr Location

2q35; chr2:218125289-218137251 (+) GRCh38

MGI Vertebrate Homology

Cxcr2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CXCR2
Gene Tree

Cxcr2

Diseases

5 with human CXCR2 associations

				Human Disease	Mouse Models
				acute pyelonephritis IDs acute pyelonephritis DOID:559 ICD10CM:N10 ICD9CM:590.1 NCI:C123215 UMLS_CUI:C0520575
				end stage renal disease IDs end stage renal disease DOID:783
				IgA glomerulonephritis IDs IgA glomerulonephritis DOID:2986 EFO:0004194 MESH:D005922 NCI:C34643 OMIM:161950 UMLS_CUI:C0017661
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695
				WHIM syndrome 2 IDs WHIM syndrome 2 DOID:0060973 OMIM:619407

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

93 phenotypes from 4 alleles in 8 genetic backgrounds
3 phenotypes from multigenic genotypes
183 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Cxcr2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are viable and fertile but exhibit splenomegaly, lymphadenopathy, and increased susceptibility to various pathogens due to impaired neutrophil recruitment and decreased pathogen clearance during innate immune responses.

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All GO Annotations

71
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

83
cDNA Data

14
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CXCR1

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS15040.1

Ensembl

ENSMUSG00000026180 (Evidence)
NCBI Gene

12765

			Length	Strain/Species	Flank
genomic	12765	NCBI Gene Model \| MGI Sequence Detail	7253	C57BL/6J	± kb
transcript	NM_009909	RefSeq \| MGI Sequence Detail	3043	ZRU/MplStud
polypeptide	P35343	UniProt \| EBI \| MGI Sequence Detail	359	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001257 C-X-C chemokine receptor type 2

(term hierarchy)
InterPro Domains

IPR000174 CXC chemokine receptor 1/2

IPR000057 CXC chemokine receptor 2

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050119 G-protein coupled receptor 1

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P35343 1 site

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All nucleic 26

Genomic 6

cDNA 15

Primer pair 3

Other 2

Microarray probesets 3

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MGD-MRK-11396, MGD-MRK-16347, MGD-MRK-32344, MGI:99567

Summaries

All 287

Developmental Gene Expression 6

Gene Ontology 10

Phenotypes 183
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:358318 Balog BM, et al., CXCR2 mediated trafficking of neutrophils and neutrophil extracellular traps are required for myelin clearance after a peripheral nerve injury. Exp Neurol. 2024 Oct 3;382:114985

TSS for Cxcr2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7354	Chr1:74193140-74193162 (+)	-2 bp
Tssr7355	Chr1:74193170-74193194 (+)	29 bp
Tssr7356	Chr1:74193241-74193244 (+)	90 bp
Tssr7357	Chr1:74194800-74194828 (+)	1,661 bp
Tssr7358	Chr1:74194829-74194845 (+)	1,684 bp
Tssr7359	Chr1:74194853-74194864 (+)	1,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24