Pnoc MGI Mouse Gene Detail - MGI:105308

Symbol

Pnoc
Name

prepronociceptin
Synonyms

N23K, N/OFQ, Npnc1, OFQ/N, proorphanin

Feature Type

protein coding gene
IDs

MGI:105308
NCBI Gene: 18155
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:65638931-65662908 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 34.33 cM, cytoband D1
Mapping Data

1 experiment

SNPs within 2kb

566 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105308	protein coding gene	Chr14:65638122-65662921 (-)
129S1/SvImJ	ENSMUSG00200029634	protein coding gene	Chr14:54237395-54262231 (-)
A/J	ENSMUSG00195012848	protein coding gene	Chr14:54414831-54439698 (-)
AKR/J	ENSMUSG00220030800	protein coding gene	Chr14:53755368-53780226 (-)
BALB/cJ	ENSMUSG00180032676	protein coding gene	Chr14:54031026-54055891 (-)
C3H/HeJ	ENSMUSG00175030808	protein coding gene	Chr14:55773789-55798625 (-)
C57BL/6NJ	ENSMUSG00215020566	protein coding gene	Chr14:53970972-53995774 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019424	protein coding gene	Chr14:56546304-56571690 (-)
CAST/EiJ	ENSTCUG00005033378	protein coding gene	Chr14:55668113-55692798 (-)
CBA/J	ENSMUSG00210034952	protein coding gene	Chr14:54402195-54427066 (-)
DBA/2J	ENSMUSG00185029169	protein coding gene	Chr14:59571606-59596424 (-)
FVB/NJ	ENSMUSG00205022949	protein coding gene	Chr14:53917666-53942526 (-)
JF1/MsJ	ENSUMUG00000021116	protein coding gene	Chr14:70738308-70763152 (-)
LP/J	ENSMUSG00230036584	protein coding gene	Chr14:71600943-71625780 (-)
NOD/ShiLtJ	ENSMUSG00190027221	protein coding gene	Chr14:54196924-54221785 (-)
NZO/HlLtJ	ENSMUSG00225038582	protein coding gene	Chr14:61929858-61954711 (-)
PWK/PhJ	ENSLUMG00010030819	protein coding gene	Chr14:53625379-53650180 (-)
SPRET/EiJ	ENSMSPG00010027592	protein coding gene	Chr14:57116173-57141060 (-)
WSB/EiJ	ENSIUOG00005035526	protein coding gene	Chr14:53632436-53657267 (-)

Human Ortholog

PNOC, prepronociceptin

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PNOC, prepronociceptin
Synonyms

N/OFQ, NOP, OFQ, PPNOC, ppN/OFQ
Links

HGNC:9163

NCBI Gene ID: 5368

UniProt: Q13519
Chr Location

8p21.1; chr8:28316986-28343355 (+) GRCh38

MGI Vertebrate Homology

Pnoc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PNOC
Gene Tree

Pnoc

Diseases

1 with human PNOC associations

				Human Disease	Mouse Models
				neonatal abstinence syndrome IDs neonatal abstinence syndrome DOID:9828 DOID:6679 ICD10CM:P96.1 ICD9CM:779.5 MESH:D009357 NCI:C35808 NCI:C87101 UMLS_CUI:C0027609 UMLS_CUI:C1332133

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

1
Targeted

6
Genomic Mutations

1 involving Pnoc
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

12 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele fail to exhibit prostaglandin E2-induced allodynia. Mice homozygous for a different knock-out allele display increased naloxone-precipitated jumping in response to morphine treatment.

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All GO Annotations

49
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

698
Tissues

81
cDNA Data

12
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pnoc

ZFIN pnoca, pnocb

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All Sequences

48
RefSeq

8
UniProt

3
CCDS

CCDS27213.1, CCDS88690.1

Ensembl

ENSMUSG00000045731 (Evidence)
NCBI Gene

18155

			Length	Strain/Species	Flank
genomic	18155	NCBI Gene Model \| MGI Sequence Detail	23978	C57BL/6J	± kb
transcript	NM_001424488	RefSeq \| MGI Sequence Detail	1077	C57BL/6
polypeptide	Q64387	UniProt \| EBI \| MGI Sequence Detail	187	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000012940 nociceptin

(term hierarchy)
InterPro Domains

IPR002367 Nociceptin

IPR061983 Nociceptin neuropeptide 2

IPR006024 Opioid neuropeptide precursor

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All nucleic 15

Genomic 1

cDNA 12

Primer pair 2

Microarray probesets 3

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MGD-MRK-32349

Summaries

All 86

Developmental Gene Expression 15

Gene Ontology 8

Phenotypes 31
Earliest

J:30116 Saito Y, et al., N23K, a gene transiently up-regulated during neural differentiation, encodes a precursor protein for a newly identified neuropeptide nociceptin. Biochem Biophys Res Commun. 1995 Dec 14;217(2):539-45
Latest

J:386102 Ortiz-Juza MM, et al., Prepronociceptin-Expressing Neurons in the Bed Nucleus of the Stria Terminalis Signal Escape Behavior. Biol Psychiatry Glob Open Sci. 2025 Sep;5(5):100538

TSS for Pnoc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129251	Chr14:65662902-65662915 (-)	-1 bp
Tssr129250	Chr14:65662618-65662637 (-)	280 bp
Tssr129249	Chr14:65642635-65642641 (-)	20,270 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24