Cit MGI Mouse Gene Detail - MGI:105313

Symbol

Cit
Name

citron
Synonyms

C030025P15Rik, Cit-k, citron kinase, citron-N, CRIK, CRIK-SK

Feature Type

protein coding gene
IDs

MGI:105313
NCBI Gene: 12704
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr5:115983337-116147006 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 56.10 cM, cytoband F
Mapping Data

2 experiments

SNPs within 2kb

4559 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105313	protein coding gene	Chr5:115983284-116147012 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029977	protein coding gene	Chr5:118765317-118944112 (+)
A/J	MGP_AJ_G0029941	protein coding gene	Chr5:114024879-114190761 (+)
AKR/J	MGP_AKRJ_G0029880	protein coding gene	Chr5:117689328-117856537 (+)
BALB/cJ	MGP_BALBcJ_G0029952	protein coding gene	Chr5:115427084-115592895 (+)
C3H/HeJ	MGP_C3HHeJ_G0029672	protein coding gene	Chr5:118204212-118373916 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0030407	protein coding gene	Chr5:123337478-123512394 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027633	protein coding gene	Chr5:108798069-108962926 (+)
CAST/EiJ	MGP_CASTEiJ_G0029081	protein coding gene	Chr5:117157272-117332664 (+)
CBA/J	MGP_CBAJ_G0029640	protein coding gene	Chr5:128070569-128249484 (+)
DBA/2J	MGP_DBA2J_G0029790	protein coding gene	Chr5:114117823-114282775 (+)
FVB/NJ	MGP_FVBNJ_G0029746	protein coding gene	Chr5:112935265-113109119 (+)
LP/J	MGP_LPJ_G0029878	protein coding gene	Chr5:119326950-119501260 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029777	protein coding gene	Chr5:132365888-132546273 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030448	protein coding gene	Chr5:117166032-117338722 (+)
PWK/PhJ	MGP_PWKPhJ_G0028794	protein coding gene	Chr5:112768683-112936786 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028632	protein coding gene	Chr5:114719662-114886684 (+)
WSB/EiJ	MGP_WSBEiJ_G0029156	protein coding gene	Chr5:117765495-117936139 (+)

Human Ortholog

CIT, citron rho-interacting serine/threonine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CIT, citron rho-interacting serine/threonine kinase
Synonyms

CITK, CRIK, MCPH17, STK21
Links

HGNC:1985

NCBI Gene ID: 11113

neXtProt AC: NX_O14578

UniProt: O14578
Chr Location

12q24.23; chr12:119685791-119877320 (-) GRCh38

MGI Vertebrate Homology

Cit stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CIT
Protein SuperFamily

Citron_Rho-interacting_kinase
Gene Tree

Cit

Diseases

2 with human CIT associations

				Human Disease	Mouse Models
				primary autosomal recessive microcephaly 17 IDs primary autosomal recessive microcephaly 17 DOID:0070288 OMIM:617090
				primary microcephaly IDs primary microcephaly DOID:0070297

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

26 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

64
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

57
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Cit
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

121 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null mutation are 20% smaller than wild-type and exhibit tremors, ataxia, and fatal seizures. Brains of mutant mice show a 50% size reduction with abnormalities in the hippocampus, cerebellum, and olfactory lobes. Mutant males show aberrant cytokinesis of spermatogenic precursors.

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All GO Annotations

74
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

968
Tissues

67
cDNA Data

15
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cit

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All Sequences

146
RefSeq

76
UniProt

8
CCDS

CCDS19597.1

Ensembl

ENSMUSG00000029516 (Evidence)
NCBI Gene

12704

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029516	Ensembl Gene Model \| MGI Sequence Detail	163670	C57BL/6J	± kb
transcript	ENSMUST00000102560	Ensembl \| MGI Sequence Detail	6213	Not Applicable
polypeptide	ENSMUSP00000099620	Ensembl \| MGI Sequence Detail	2070	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000005504 citron Rho-interacting kinase

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR000961 AGC-kinase, C-terminal

IPR046349 C1-like domain superfamily

IPR001180 Citron homology (CNH) domain

IPR017405 Citron Rho-interacting kinase

IPR037708 Citron Rho-interacting kinase, catalytic domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR017892 Protein kinase, C-terminal

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR050839 Rho-associated Serine/Threonine Kinase

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P49025 2 sites, 2 N-linked glycans (2 sites)

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All nucleic 21

cDNA 16

Primer pair 5

Microarray probesets 8

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MGD-MRK-32354, MGI:2444984

Summaries

All 66

Developmental Gene Expression 13

Gene Ontology 16

Phenotypes 25
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cit:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr48325	Chr5:115983288-115983360 (+)	-13 bp
Tssr48326	Chr5:115997095-115997133 (+)	13,777 bp
Tssr48327	Chr5:115997182-115997191 (+)	13,850 bp
Tssr48328	Chr5:116004542-116004547 (+)	21,208 bp
Tssr48329	Chr5:116045507-116045567 (+)	62,200 bp
Tssr48330	Chr5:116045594-116045609 (+)	62,265 bp
Tssr48331	Chr5:116046573-116046581 (+)	63,240 bp
Tssr48332	Chr5:116046582-116046597 (+)	63,253 bp
Tssr48333	Chr5:116046754-116046793 (+)	63,437 bp
Tssr48334	Chr5:116083367-116083400 (+)	100,047 bp
Tssr48335	Chr5:116085985-116086006 (+)	102,659 bp
Tssr48336	Chr5:116112913-116112915 (+)	129,577 bp
Tssr48337	Chr5:116127874-116127879 (+)	144,540 bp
Tssr48338	Chr5:116144836-116144840 (+)	161,501 bp
Tssr48339	Chr5:116144890-116144894 (+)	161,555 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24