Cbx1 MGI Mouse Gene Detail - MGI:105369

Symbol

Cbx1
Name

chromobox 1
Synonyms

Cbx-rs2, E430007M08Rik, HP1B, Hp1beta, M31, MOD1

Feature Type

protein coding gene
IDs

MGI:105369
NCBI Gene: 12412
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr11:96679953-96699466 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 60.11 cM
Mapping Data

6 experiments

SNPs within 2kb

463 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105369	protein coding gene	Chr11:96679506-96699808 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019012	protein coding gene	Chr11:99136399-99163249 (+)
A/J	MGP_AJ_G0018980	protein coding gene	Chr11:95077175-95098498 (+)
AKR/J	MGP_AKRJ_G0018950	protein coding gene	Chr11:98022720-98046179 (+)
BALB/cJ	MGP_BALBcJ_G0018953	protein coding gene	Chr11:95577544-95597726 (+)
C3H/HeJ	MGP_C3HHeJ_G0018767	protein coding gene	Chr11:98152295-98172271 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019405	protein coding gene	Chr11:102221366-102241723 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017035	protein coding gene	Chr11:92559746-92580420 (+)
CAST/EiJ	MGP_CASTEiJ_G0018320	protein coding gene	Chr11:98988927-99010186 (+)
CBA/J	MGP_CBAJ_G0018738	protein coding gene	Chr11:106402265-106425844 (+)
DBA/2J	MGP_DBA2J_G0018846	protein coding gene	Chr11:94640658-94661036 (+)
FVB/NJ	MGP_FVBNJ_G0018835	protein coding gene	Chr11:94118891-94139436 (+)
LP/J	MGP_LPJ_G0018916	protein coding gene	Chr11:99659939-99681134 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018862	protein coding gene	Chr11:106363439-106384349 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019445	protein coding gene	Chr11:98325817-98348159 (+)
PWK/PhJ	MGP_PWKPhJ_G0018092	protein coding gene	Chr11:95608932-95629149 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017881	protein coding gene	Chr11:98056715-98078543 (+)
WSB/EiJ	MGP_WSBEiJ_G0018370	protein coding gene	Chr11:98233340-98256212 (+)

Human Ortholog

CBX1, chromobox 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CBX1, chromobox 1
Synonyms

CBX, HP1-BETA, Hp1beta, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
Links

HGNC:1551

NCBI Gene ID: 10951

neXtProt AC: NX_P83916

UniProt: P83916
Chr Location

17q21.32; chr17:48070052-48101478 (-) GRCh38

MGI Vertebrate Homology

Cbx1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CBX1
Gene Tree

Cbx1

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

238
Endonuclease-mediated

1
Gene trapped

229
Targeted

8
Genomic Mutations

1 involving Cbx1
Incidental Mutations

APF
Find Mice (IMSR)

91 strains or lines available

An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.

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All GO Annotations

42
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1003
Tissues

153
cDNA Data

101
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CBX1

Xenbase cbx1

ZFIN cbx1a

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All Sequences

63
RefSeq

18
UniProt

3
CCDS

CCDS25303.1, CCDS88236.1

Ensembl

ENSMUSG00000018666 (Evidence)
NCBI Gene

12412

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018666	Ensembl Gene Model \| MGI Sequence Detail	19514	C57BL/6J	± kb
transcript	ENSMUST00000093943	Ensembl \| MGI Sequence Detail	1251	Not Applicable
polypeptide	ENSMUSP00000091475	Ensembl \| MGI Sequence Detail	185	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005082 chromobox protein homolog 1

(term hierarchy)
PDB

1AP0, 1DZ1, 1GUW, 1S4Z
InterPro Domains

IPR000953 Chromo/chromo shadow domain

IPR023780 Chromo domain

IPR023779 Chromo domain, conserved site

IPR017984 Chromo domain subgroup

IPR016197 Chromo-like domain superfamily

IPR008251 Chromo shadow domain

IPR051219 Heterochromatin-associated chromo domain-containing protein

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All nucleic 107

Genomic 1

cDNA 102

Primer pair 3

Other 1

Microarray probesets 8

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MGD-MRK-1790, MGD-MRK-33038, MGI:2442882

Summaries

All 107

Developmental Gene Expression 21

Gene Ontology 18

Phenotypes 26
Earliest

J:32398 Singh PB, et al., A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991 Feb 25;19(4):789-94
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cbx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr104569	Chr11:96679944-96679972 (+)	5 bp
Tssr104570	Chr11:96679975-96680032 (+)	51 bp
Tssr104571	Chr11:96680039-96680050 (+)	92 bp
Tssr104572	Chr11:96680061-96680080 (+)	118 bp
Tssr104573	Chr11:96698511-96698545 (+)	18,575 bp
Tssr104574	Chr11:96698618-96698628 (+)	18,670 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24