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Adam9 Gene Detail
Summary
  • Symbol
    Adam9
  • Name
    ADAM metallopeptidase domain 9
  • Synonyms
    MDC9, MDC9, mKIAA0021, Mltng, Mltng
  • Feature Type
    protein coding gene
  • IDs
    MGI:105376
    NCBI Gene: 11502
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25439627-25506943 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 13.70 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1914 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105376
 protein coding gene Chr8:25439627-25507138 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033476
 protein coding gene Chr8:22950435-23015175 (-)
A/J MGP_AJ_G0033456
 protein coding gene Chr8:22142229-22209163 (-)
AKR/J MGP_AKRJ_G0033381
 protein coding gene Chr8:22858519-22925531 (-)
BALB/cJ MGP_BALBcJ_G0033452
 protein coding gene Chr8:22286211-22353635 (-)
C3H/HeJ MGP_C3HHeJ_G0033166
 protein coding gene Chr8:23075070-23142748 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033968
 protein coding gene Chr8:23885505-23958182 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030918
 protein coding gene Chr8:19428585-19492432 (-)
CAST/EiJ MGP_CASTEiJ_G0032492
 protein coding gene Chr8:22496477-22568504 (-)
CBA/J MGP_CBAJ_G0033141
 protein coding gene Chr8:24811981-24877837 (-)
DBA/2J MGP_DBA2J_G0033296
 protein coding gene Chr8:22112618-22179479 (-)
FVB/NJ MGP_FVBNJ_G0033240
 protein coding gene Chr8:21908832-21979750 (-)
LP/J MGP_LPJ_G0033385
 protein coding gene Chr8:22939072-23006108 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033283
 protein coding gene Chr8:24328238-24396520 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033987
 protein coding gene Chr8:22808494-22877938 (-)
PWK/PhJ MGP_PWKPhJ_G0032203
 protein coding gene Chr8:21713270-21783584 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032037
 protein coding gene Chr8:22145847-22214645 (-)
WSB/EiJ MGP_WSBEiJ_G0032608
 protein coding gene Chr8:23009644-23077975 (-)



Homology
more
  • Human Ortholog
    ADAM9, ADAM metallopeptidase domain 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM9, ADAM metallopeptidase domain 9
  • Synonyms
    CORD9, MCMP, MDC9, Mltng
  • Links
    NCBI Gene ID: 8754
    neXtProt AC: NX_Q13443
    UniProt: Q13443

  • Chr Location
    8p11.22; chr8:38996754-39105445 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Adam9 mouse models; 1 with human ADAM9 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibit progressive retinal degeneration, disorganized retinal layers and a degenerate retinal pigment epithelium.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    20
  • cDNA Data
    131
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031555 Ensembl Gene Model | MGI Sequence Detail 67317 C57BL/6J ±  kb
    transcript ENSMUST00000208247 Ensembl | MGI Sequence Detail 4044 Not Applicable  
    polypeptide ENSMUSP00000146545 Ensembl | MGI Sequence Detail 863 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 131
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33045, MGI:2142696
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 15
      Phenotypes 22
    • Earliest
      J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
    • Latest
      J:309162 Umeda M, et al., ADAM9 enhances Th17 cell differentiation and autoimmunity by activating TGF-beta1. Proc Natl Acad Sci U S A. 2021 May 4;118(18):e2023230118
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory