Il18r1 MGI Mouse Gene Detail - MGI:105383 - interleukin 18 receptor 1

Symbol

Il18r1
Name

interleukin 18 receptor 1
Synonyms

Il18ralpha, Il1rrp

Feature Type

protein coding gene
IDs

MGI:105383
NCBI Gene: 16182
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:40504712-40540014 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 19.27 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

1307 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105383	protein coding gene	Chr1:40504712-40540014 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015968	protein coding gene	Chr1:39266592-39305449 (+)
A/J	MGP_AJ_G0015952	protein coding gene	Chr1:38154505-38190484 (+)
AKR/J	MGP_AKRJ_G0015907	protein coding gene	Chr1:38631028-38667398 (+)
BALB/cJ	MGP_BALBcJ_G0015906	protein coding gene	Chr1:37805309-37840313 (+)
C3H/HeJ	MGP_C3HHeJ_G0015739	protein coding gene	Chr1:38936580-38972103 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016359	protein coding gene	Chr1:40872975-40912268 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014081	protein coding gene	Chr1:35077980-35113016 (+)
CAST/EiJ	MGP_CASTEiJ_G0015320	protein coding gene	Chr1:38828542-38865185 (+)
CBA/J	MGP_CBAJ_G0015711	protein coding gene	Chr1:42079970-42116698 (+)
DBA/2J	MGP_DBA2J_G0015812	protein coding gene	Chr1:37428858-37463751 (+)
FVB/NJ	MGP_FVBNJ_G0015814	protein coding gene	Chr1:36977440-37012535 (+)
LP/J	MGP_LPJ_G0015882	protein coding gene	Chr1:39596075-39632239 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015834	protein coding gene	Chr1:44090855-44127295 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016406	protein coding gene	Chr1:38792284-38827955 (+)
PWK/PhJ	MGP_PWKPhJ_G0015103	protein coding gene	Chr1:37243724-37279743 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014885	protein coding gene	Chr1:38757395-38792565 (+)
WSB/EiJ	MGP_WSBEiJ_G0015382	protein coding gene	Chr1:38762293-38797443 (+)

Human Ortholog

IL18R1, interleukin 18 receptor 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL18R1, interleukin 18 receptor 1
Synonyms

CD218a, CDw218a, IL18RA, IL-18R-alpha, IL-18Ralpha, IL18Ralpha2, IL-1Rrp, IL1RRP
Links

HGNC:5988

NCBI Gene ID: 8809

neXtProt AC: NX_Q13478

UniProt: Q13478
Chr Location

2q12.1; chr2:102311529-102398777 (+) GRCh38

MGI Vertebrate Homology

Il18r1 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL18R1
Gene Tree

Il18r1

Diseases

1 with human IL18R1 associations

				Human Disease	Mouse Models
				asthma IDs asthma DOID:2841 DOID:12703 DOID:13829 DOID:13830 DOID:2840 DOID:5783 ICD10CM:J45 ICD9CM:493 ICD9CM:493.9 KEGG:05310 MESH:D001249 NCI:C28397 OMIM:600807 UMLS_CUI:C0004096

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
119 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

7
Targeted

3
Genomic Mutations

1 involving Il18r1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene exhibit impaire Th1 cell development and defective NK cell physiology.

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All GO Annotations

33
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

2
cDNA Data

10
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il18r1

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All Sequences

55
RefSeq

18
UniProt

4
CCDS

CCDS35549.1, CCDS48247.1

Ensembl

ENSMUSG00000026070 (Evidence)
NCBI Gene

16182

			Length	Strain/Species	Flank
genomic	16182	NCBI Gene Model \| MGI Sequence Detail	35303	C57BL/6J	± kb
transcript	NM_008365	RefSeq \| MGI Sequence Detail	4158	C57BL/6
polypeptide	Q61098	UniProt \| EBI \| MGI Sequence Detail	537	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001377 interleukin-18 receptor 1

(term hierarchy)
EC

3.2.2.6
InterPro Domains

IPR041416 IL-1Ra-like, immunoglobulin domain

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR015621 Interleukin-1 receptor family

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain

IPR035897 Toll/interleukin-1 receptor homology (TIR) domain superfamily
GlyGen

Q61098 10 sites, 1 N-linked glycan (1 site)

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

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MGD-MRK-33052

Summaries

All 159

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 119
Earliest

J:31466 Parnet P, et al., IL-1Rrp is a novel receptor-like molecule similar to the type I interleukin-1 receptor and its homologues T1/ST2 and IL-1R AcP. J Biol Chem. 1996 Feb 23;271(8):3967-70
Latest

J:355519 Oberkircher LM, et al., Opposing roles of resident and infiltrating immune cells in the defense against Legionella longbeachae via IL-18R/IFN-gamma/ROS axis in mice. Mucosal Immunol. 2024 Oct;17(5):777-792

TSS for Il18r1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6465	Chr1:40504801-40504858 (+)	118 bp
Tssr6466	Chr1:40504863-40504889 (+)	164 bp
Tssr6467	Chr1:40505125-40505135 (+)	418 bp
Tssr6468	Chr1:40505136-40505166 (+)	439 bp
Tssr6469	Chr1:40505229-40505238 (+)	522 bp
Tssr6470	Chr1:40505248-40505271 (+)	548 bp
Tssr6471	Chr1:40505340-40505370 (+)	643 bp
Tssr6472	Chr1:40505454-40505462 (+)	746 bp
Tssr6473	Chr1:40530212-40530215 (+)	25,502 bp
Tssr6474	Chr1:40539169-40539185 (+)	34,465 bp
Tssr6475	Chr1:40539531-40539543 (+)	34,825 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24