Cdkn2c MGI Mouse Gene Detail - MGI:105388 - cyclin dependent kinase inhibitor 2C

Symbol

Cdkn2c
Name

cyclin dependent kinase inhibitor 2C
Synonyms

INK4c, p18, p18INK4c

Feature Type

protein coding gene
IDs

MGI:105388
NCBI Gene: 12580
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr4:109518073-109523953 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 51.32 cM
Mapping Data

3 experiments

SNPs within 2kb

142 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105388	protein coding gene	Chr4:109518073-109524386 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028573	protein coding gene	Chr4:110431644-110437711 (-)
A/J	MGP_AJ_G0028536	protein coding gene	Chr4:106457868-106464161 (-)
AKR/J	MGP_AKRJ_G0028483	protein coding gene	Chr4:109121009-109127310 (-)
BALB/cJ	MGP_BALBcJ_G0028555	protein coding gene	Chr4:106673410-106679700 (-)
C3H/HeJ	MGP_C3HHeJ_G0028269	protein coding gene	Chr4:109873727-109880017 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028995	protein coding gene	Chr4:114417409-114423418 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026286	protein coding gene	Chr4:101751508-101757796 (-)
CAST/EiJ	MGP_CASTEiJ_G0027705	protein coding gene	Chr4:107714206-107722079 (-)
CBA/J	MGP_CBAJ_G0028238	protein coding gene	Chr4:118162464-118168717 (-)
DBA/2J	MGP_DBA2J_G0028386	protein coding gene	Chr4:106084953-106091242 (-)
FVB/NJ	MGP_FVBNJ_G0028354	protein coding gene	Chr4:104959826-104966386 (-)
LP/J	MGP_LPJ_G0028487	protein coding gene	Chr4:110705223-110712769 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028380	protein coding gene	Chr4:123344110-123350069 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029031	protein coding gene	Chr4:109352075-109358388 (-)
PWK/PhJ	MGP_PWKPhJ_G0027431	protein coding gene	Chr4:104375365-104381763 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027255	protein coding gene	Chr4:106737579-106743896 (-)
WSB/EiJ	MGP_WSBEiJ_G0027786	protein coding gene	Chr4:109539009-109547151 (-)

Human Ortholog

CDKN2C, cyclin dependent kinase inhibitor 2C

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CDKN2C, cyclin dependent kinase inhibitor 2C
Synonyms

INK4C, p18, p18-INK4C
Links

HGNC:1789

NCBI Gene ID: 1031

neXtProt AC: NX_P42773

UniProt: P42773
Chr Location

1p32.3; chr1:50960745-50974634 (+) GRCh38

MGI Vertebrate Homology

Cdkn2c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CDKN2C
Gene Tree

Cdkn2c

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Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

50 phenotypes from 2 alleles in 4 genetic backgrounds
62 phenotypes from multigenic genotypes
73 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

23
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

8
Radiation induced

1
Targeted

7
Genomic Mutations

4 involving Cdkn2c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit kidney and mammary gland cortical cysts, Leydig cell hyperplasia, reduced testosterone levels, late developing thymic lymphomas and pituitary tumors, gigantism, and organomegaly.

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All GO Annotations

22
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

947
Tissues

157
cDNA Data

42
Literature Summary

38

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CDKN2C

Xenbase cdkn2c

ZFIN cdkn2c

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All Sequences

42
RefSeq

4
UniProt

3
CCDS

CCDS18467.1

Ensembl

ENSMUSG00000028551 (Evidence)
NCBI Gene

12580

			Length	Strain/Species	Flank
genomic	12580	NCBI Gene Model \| MGI Sequence Detail	5881	C57BL/6J	± kb
transcript	NM_001301368	RefSeq \| MGI Sequence Detail	2043	C57BL/6
polypeptide	Q60772	UniProt \| EBI \| MGI Sequence Detail	168	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005278 cyclin-dependent kinase 4 inhibitor C

(term hierarchy)
InterPro Domains

IPR002110 Ankyrin repeat

IPR050776 Ankyrin Repeat and Cyclin-Dependent Kinase Inhibitor

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 50

cDNA 42

Primer pair 6

Other 2

Microarray probesets 5

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MGD-MRK-33058, MGI:2140654

Summaries

All 150

Developmental Gene Expression 38

Diseases 2

Gene Ontology 4

Phenotypes 73
Earliest

J:24521 Hirai H, et al., Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6. Mol Cell Biol. 1995 May;15(5):2672-81
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Cdkn2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42782	Chr4:109524013-109524043 (-)	-75 bp
Tssr42781	Chr4:109523967-109523987 (-)	-24 bp
Tssr42780	Chr4:109523925-109523962 (-)	9 bp
Tssr42779	Chr4:109523807-109523850 (-)	124 bp
Tssr42778	Chr4:109522877-109522908 (-)	1,060 bp
Tssr42777	Chr4:109522504-109522517 (-)	1,442 bp
Tssr1259	Chr4:109522478-109522493 (-)	1,467 bp
Tssr42776	Chr4:109522446-109522475 (-)	1,492 bp
Tssr42775	Chr4:109518457-109518472 (-)	5,488 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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