Lair1 MGI Mouse Gene Detail - MGI:105492 - leukocyte-associated Ig-like receptor 1

Symbol

Lair1
Name

leukocyte-associated Ig-like receptor 1
Synonyms

5133400O11Rik, D7Bwg0421e, Lair-1, mLair-1

Feature Type

protein coding gene
IDs

MGI:105492
NCBI Gene: 52855
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:4006401-4066178 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.31 cM
Mapping Data

5 experiments

SNPs within 2kb

1100 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105492	protein coding gene	Chr7:4006401-4076566 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031536	protein coding gene	Chr7:933671-984400 (-)
A/J	MGP_AJ_G0031510	protein coding gene	Chr7:899742-953894 (-)
AKR/J	MGP_AKRJ_G0031438	protein coding gene	Chr7:974702-1023249 (-)
BALB/cJ	MGP_BALBcJ_G0031518	protein coding gene	Chr7:989510-1035832 (-)
C3H/HeJ	MGP_C3HHeJ_G0031239	protein coding gene	Chr7:961000-1016404 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031979	protein coding gene	Chr7:976084-1018100 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029103	protein coding gene	Chr7:707435-761845 (-)
CAST/EiJ	MGP_CASTEiJ_G0030603	protein coding gene	Chr7:909301-991738 (-)
CBA/J	MGP_CBAJ_G0031197	protein coding gene	Chr7:1150049-1203302 (-)
DBA/2J	MGP_DBA2J_G0031356	protein coding gene	Chr7:896965-946262 (-)
FVB/NJ	MGP_FVBNJ_G0031308	protein coding gene	Chr7:869016-927451 (-)
LP/J	MGP_LPJ_G0031441	protein coding gene	Chr7:1006842-1070811 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031347	protein coding gene	Chr7:1014620-1081451 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032009	protein coding gene	Chr7:892690-955228 (-)
PWK/PhJ	MGP_PWKPhJ_G0030331	protein coding gene	Chr7:1094713-1144848 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030156	protein coding gene	Chr7:1024679-1082265 (-)
WSB/EiJ	MGP_WSBEiJ_G0030698	protein coding gene	Chr7:918710-973357 (-)

Human Ortholog

LAIR1, leukocyte associated immunoglobulin like receptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAIR1, leukocyte associated immunoglobulin like receptor 1
Synonyms

CD305, LAIR-1
Links

HGNC:6477

NCBI Gene ID: 3903

neXtProt AC: NX_Q6GTX8

UniProt: Q6GTX8
Chr Location

19q13.42; chr19:54351384-54376088 (-) GRCh38

Human Ortholog

LAIR2, leukocyte associated immunoglobulin like receptor 2
Synonyms

CD306
Links

HGNC:6478

NCBI Gene ID: 3904

neXtProt AC: NX_Q6ISS4

UniProt: Q6ISS4
Chr Location

19q13.42; chr19:54497879-54510687 (+) GRCh38

MGI Vertebrate Homology

Lair1 stringent orthology
2 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LAIR1, LAIR2
Gene Tree

Lair1

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

5
Gene trapped

1
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

37 strains or lines available

Mice homozygous for a knock-out allele are healthy and of normal longevity but show increased numbers of splenic B, regulatory T, and dendritic cells, and eosinophilia at a young age. Aging homozygotes display a higher frequency of activated and effector/memory T cells and a decreased IgG1 level.

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

91
RefSeq

26
UniProt

1
CCDS

CCDS20729.1, CCDS51969.1, CCDS80654.1, CCDS85202.1

Ensembl

ENSMUSG00000055541 (Evidence)
NCBI Gene

52855

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055541	Ensembl Gene Model \| MGI Sequence Detail	59778	C57BL/6J	± kb
transcript	ENSMUST00000086401	Ensembl \| MGI Sequence Detail	2496	Not Applicable
polypeptide	ENSMUSP00000083589	Ensembl \| MGI Sequence Detail	263	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001877 leukocyte-associated immunoglobulin-like receptor 1

(term hierarchy)
PDB

4ESK, 4ETY
InterPro Domains

IPR013151 Immunoglobulin

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR050412 Immunoglobulin-like Receptors in Immune Regulation
GlyGen

Q8BG84 2 sites

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All nucleic 12

cDNA 11

Primer pair 1

Microarray probesets 5

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MGD-MRK-33164, MGI:1918474, MGI:2142289

Summaries

All 46

Gene Ontology 4

Phenotypes 17
Earliest

J:44191 Kubagawa H, et al., A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells [see comments]. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5261-6
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Lair1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70444	Chr7:4066194-4066209 (-)	-24 bp
Tssr70443	Chr7:4066154-4066187 (-)	7 bp
Tssr70442	Chr7:4066125-4066138 (-)	46 bp
Tssr70441	Chr7:4065682-4065687 (-)	493 bp
Tssr70440	Chr7:4031787-4031797 (-)	34,386 bp
Tssr70439	Chr7:4027506-4027533 (-)	38,658 bp
Tssr70438	Chr7:4012512-4012523 (-)	53,660 bp
Tssr70437	Chr7:4011375-4011392 (-)	54,794 bp
Tssr70436	Chr7:4011350-4011371 (-)	54,817 bp
Tssr70435	Chr7:4011105-4011116 (-)	55,067 bp
Tssr70434	Chr7:4011007-4011025 (-)	55,162 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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