Fer MGI Mouse Gene Detail - MGI:105917

Symbol

Fer
Name

FER tyrosine kinase
Synonyms

C330004K01Rik, Fert, Fert2

Feature Type

protein coding gene
IDs

MGI:105917
NCBI Gene: 14158
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr17:64170057-64446491 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 33.06 cM
Mapping Data

5 experiments

SNPs within 2kb

7663 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105917	protein coding gene	Chr17:64136945-64453515 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023972	protein coding gene	Chr17:65916474-66213199 (+)
A/J	MGP_AJ_G0023930	protein coding gene	Chr17:63978425-64260978 (+)
AKR/J	MGP_AKRJ_G0023899	protein coding gene	Chr17:64836426-65119436 (+)
BALB/cJ	MGP_BALBcJ_G0023931	protein coding gene	Chr17:63898935-64174412 (+)
C3H/HeJ	MGP_C3HHeJ_G0023695	protein coding gene	Chr17:65716621-65997600 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024377	protein coding gene	Chr17:68484363-68783746 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021823	protein coding gene	Chr17:60099612-60368603 (+)
CAST/EiJ	MGP_CASTEiJ_G0023177	protein coding gene	Chr17:66042819-66354147 (+)
CBA/J	MGP_CBAJ_G0023671	protein coding gene	Chr17:71225631-71542158 (+)
DBA/2J	MGP_DBA2J_G0023799	protein coding gene	Chr17:62739752-63012911 (+)
FVB/NJ	MGP_FVBNJ_G0023765	protein coding gene	Chr17:62217989-62488951 (+)
LP/J	MGP_LPJ_G0023881	protein coding gene	Chr17:66695572-66955428 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023793	protein coding gene	Chr17:71318128-71639336 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024421	protein coding gene	Chr17:65317554-65592380 (+)
PWK/PhJ	MGP_PWKPhJ_G0022923	protein coding gene	Chr17:61982787-62269453 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022734	protein coding gene	Chr17:61999384-62278352 (+)
WSB/EiJ	MGP_WSBEiJ_G0023243	protein coding gene	Chr17:65973740-66271302 (+)

Human Ortholog

FER, FER tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FER, FER tyrosine kinase
Synonyms

p94-Fer, PPP1R74, TYK3
Links

HGNC:3655

NCBI Gene ID: 2241

neXtProt AC: NX_P16591

UniProt: P16591
Chr Location

5q21.3; chr5:108747841-109196841 (+) GRCh38

MGI Vertebrate Homology

Fer stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FER
Protein SuperFamily

TyrPK_fps
Gene Tree

Fer

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Phenotype Summary

16 phenotypes from 3 alleles in 2 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

2
Gene trapped

9
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted mutation exhibit elevated lipopolysaccharide-induced leukocyte adhesion and migration. Mutant cells also exhibit reduced phosphorylation of cortactin.

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All GO Annotations

94
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

28
cDNA Data

16
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN fer

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All Sequences

78
RefSeq

32
UniProt

5
CCDS

CCDS28936.1, CCDS28937.1, CCDS89132.1

Ensembl

ENSMUSG00000000127 (Evidence)
NCBI Gene

14158

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000127	Ensembl Gene Model \| MGI Sequence Detail	276435	C57BL/6J	± kb
transcript	ENSMUST00000000129	Ensembl \| MGI Sequence Detail	2973	Not Applicable
polypeptide	ENSMUSP00000000129	Ensembl \| MGI Sequence Detail	823	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007458 tyrosine-protein kinase Fer

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR031160 F-BAR domain

IPR001060 FCH domain

IPR035849 Fes/Fps/Fer, SH2 domain

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR037452 Tyrosine-protein kinase Fer, F-BAR domain

IPR016250 Tyrosine-protein kinase, Fes/Fps type

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 4

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MGD-MRK-33594, MGD-MRK-9756, MGD-MRK-9757, MGI:1924790, MGI:2147017

Summaries

All 70

Developmental Gene Expression 2

Gene Ontology 19

Phenotypes 18
Earliest

J:10171 Fischman K, et al., A murine fer testis-specific transcript (ferT) encodes a truncated Fer protein. Mol Cell Biol. 1990 Jan;10(1):146-53
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fer:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145543	Chr17:64170036-64170075 (+)	-1 bp
Tssr145544	Chr17:64170114-64170138 (+)	69 bp
Tssr145545	Chr17:64170967-64171033 (+)	943 bp
Tssr145546	Chr17:64171036-64171047 (+)	985 bp
Tssr145547	Chr17:64203046-64203058 (+)	32,995 bp
Tssr145548	Chr17:64244946-64244967 (+)	74,900 bp
Tssr145549	Chr17:64385894-64385914 (+)	215,847 bp
Tssr5188	Chr17:64407430-64407458 (+)	237,387 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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