Rab5a MGI Mouse Gene Detail - MGI:105926 - RAB5A, member RAS oncogene family

Symbol

Rab5a
Name

RAB5A, member RAS oncogene family
Synonyms

2410015H04Rik

Feature Type

protein coding gene
IDs

MGI:105926
NCBI Gene: 271457
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr17:53786262-53814706 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 27.82 cM
Mapping Data

3 experiments

SNPs within 2kb

604 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105926	protein coding gene	Chr17:53786262-53814708 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023887	protein coding gene	Chr17:55033178-55061353 (+)
A/J	MGP_AJ_G0023847	protein coding gene	Chr17:53480609-53508718 (+)
AKR/J	MGP_AKRJ_G0023815	protein coding gene	Chr17:54113538-54142818 (+)
BALB/cJ	MGP_BALBcJ_G0023849	protein coding gene	Chr17:53367521-53394738 (+)
C3H/HeJ	MGP_C3HHeJ_G0023612	protein coding gene	Chr17:54839388-54867316 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024293	protein coding gene	Chr17:57157332-57189196 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021741	protein coding gene	Chr17:50091148-50118153 (+)
CAST/EiJ	MGP_CASTEiJ_G0023094	protein coding gene	Chr17:55148579-55176006 (+)
CBA/J	MGP_CBAJ_G0023588	protein coding gene	Chr17:59282450-59315257 (+)
DBA/2J	MGP_DBA2J_G0023717	protein coding gene	Chr17:52253057-52281983 (+)
FVB/NJ	MGP_FVBNJ_G0023683	protein coding gene	Chr17:51884861-51917249 (+)
LP/J	MGP_LPJ_G0023797	protein coding gene	Chr17:55738637-55766823 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023711	protein coding gene	Chr17:58711757-58738814 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024338	protein coding gene	Chr17:54425178-54453676 (+)
PWK/PhJ	MGP_PWKPhJ_G0022839	protein coding gene	Chr17:51718408-51754275 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022653	protein coding gene	Chr17:51346599-51373257 (+)
WSB/EiJ	MGP_WSBEiJ_G0023158	protein coding gene	Chr17:55092080-55120894 (+)

Human Ortholog

RAB5A, RAB5A, member RAS oncogene family

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RAB5A, RAB5A, member RAS oncogene family
Synonyms

RAB5
Links

HGNC:9783

NCBI Gene ID: 5868

neXtProt AC: NX_P20339

UniProt: P20339
Chr Location

3p24.3; chr3:19947097-19985175 (+) GRCh38

MGI Vertebrate Homology

Rab5a stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: RAB5A
Gene Tree

Rab5a

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Endonuclease-mediated

5
Gene trapped

14
Targeted

2
Incidental Mutations

Mutagenetix , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

111
GO References

37

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

21
cDNA Data

21
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rab5a

ZFIN rab5aa, rab5ab

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All Sequences

50
RefSeq

2
UniProt

2
CCDS

CCDS28879.1

Ensembl

ENSMUSG00000017831 (Evidence)
NCBI Gene

271457

			Length	Strain/Species	Flank
genomic	271457	NCBI Gene Model \| MGI Sequence Detail	28445	C57BL/6J	± kb
transcript	NM_025887	RefSeq \| MGI Sequence Detail	2364	ZRU/MplStud
polypeptide	Q9CQD1	UniProt \| EBI \| MGI Sequence Detail	215	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013633 Ras-related protein Rab-5A

(term hierarchy)
EC

3.6.5.2
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001806 Small GTPase

IPR005225 Small GTP-binding protein domain
GlyGen

Q9CQD1 1 site, 1 O-linked glycan (1 site)

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All nucleic 22

cDNA 21

Other 1

Microarray probesets 3

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MGD-MRK-33604, MGI:1914237, MGI:2146915, MGI:2146988

Summaries

All 112

Developmental Gene Expression 20

Gene Ontology 37

Phenotypes 16
Earliest

J:18627 Bucci C, et al., Rab5a is a common component of the apical and basolateral endocytic machinery in polarized epithelial cells. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5061-5
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rab5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145211	Chr17:53786240-53786265 (+)	-9 bp
Tssr145212	Chr17:53786270-53786331 (+)	39 bp
Tssr145213	Chr17:53786365-53786415 (+)	128 bp
Tssr145214	Chr17:53786457-53786476 (+)	205 bp
Tssr145215	Chr17:53786487-53786498 (+)	231 bp
Tssr145216	Chr17:53786501-53786522 (+)	250 bp
Tssr145217	Chr17:53786530-53786539 (+)	273 bp
Tssr145218	Chr17:53786555-53786566 (+)	299 bp
Tssr145219	Chr17:53798391-53798421 (+)	12,144 bp
Tssr145220	Chr17:53799916-53799920 (+)	13,656 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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