Renbp MGI Mouse Gene Detail - MGI:105940

Symbol

Renbp
Name

renin binding protein

Feature Type

protein coding gene
IDs

MGI:105940
NCBI Gene: 19703
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

ChrX:72965727-72974408 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 37.49 cM
Mapping Data

4 experiments

SNPs within 2kb

267 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_105940	protein coding gene	ChrX:72965727-72974456 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035827	protein coding gene	ChrX:69704290-69713013 (-)
A/J	MGP_AJ_G0035808	protein coding gene	ChrX:69899811-69908308 (-)
AKR/J	MGP_AKRJ_G0035733	protein coding gene	ChrX:71743484-71753658 (-)
BALB/cJ	MGP_BALBcJ_G0035793	protein coding gene	ChrX:68926087-68934904 (-)
C3H/HeJ	MGP_C3HHeJ_G0035498	protein coding gene	ChrX:70180008-70189640 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0036323	protein coding gene	ChrX:71847401-71856906 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033167	protein coding gene	ChrX:68929742-68938511 (-)
CAST/EiJ	MGP_CASTEiJ_G0034789	protein coding gene	ChrX:55530502-55539085 (-)
CBA/J	MGP_CBAJ_G0035473	protein coding gene	ChrX:73843474-73854304 (-)
DBA/2J	MGP_DBA2J_G0035630	protein coding gene	ChrX:69354772-69363500 (-)
FVB/NJ	MGP_FVBNJ_G0035574	protein coding gene	ChrX:68685311-68702250 (-)
LP/J	MGP_LPJ_G0035715	protein coding gene	ChrX:70485305-70495226 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035612	protein coding gene	ChrX:76395473-76405764 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036345	protein coding gene	ChrX:69526438-69535135 (-)
PWK/PhJ	MGP_PWKPhJ_G0034488	protein coding gene	ChrX:53537603-53546986 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0034322	protein coding gene	ChrX:56426298-56435429 (-)
WSB/EiJ	MGP_WSBEiJ_G0034930	protein coding gene	ChrX:68797983-68807966 (-)

Human Ortholog

RENBP, renin binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RENBP, renin binding protein
Synonyms

RBP, RNBP
Links

HGNC:9959

NCBI Gene ID: 5973

neXtProt AC: NX_P51606

UniProt: P51606
Chr Location

Xq28; chrX:153935269-153944687 (-) GRCh38

MGI Vertebrate Homology

Renbp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RENBP
Gene Tree

Renbp

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

3
Targeted

2
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation exhibit normal function of the renin-angiotensin system and blood pressure regulation; however, abnormalites in urine carbohydrates were noted.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

55
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase renbp

ZFIN renbp

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All Sequences

80
RefSeq

16
UniProt

5
CCDS

CCDS41015.2, CCDS57763.1

Ensembl

ENSMUSG00000031387 (Evidence)
NCBI Gene

19703

			Length	Strain/Species	Flank
genomic	19703	NCBI Gene Model \| MGI Sequence Detail	8682	C57BL/6J	± kb
transcript	NR_189639	RefSeq \| MGI Sequence Detail	1524	C57BL/6
polypeptide	P82343	UniProt \| EBI \| MGI Sequence Detail	419	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013884 N-acylglucosamine 2-epimerase

(term hierarchy)
EC

5.1.3.8
InterPro Domains

IPR034116 AGE domain

IPR010819 N-acylglucosamine 2-epimerase/Cellobiose 2-epimerase

IPR012341 Six-hairpin glycosidase-like superfamily

IPR008928 Six-hairpin glycosidase superfamily
GlyGen

P82343 1 site, 1 O-linked glycan (1 site)

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All nucleic 58

Genomic 3

cDNA 55

Microarray probesets 4

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MGD-MRK-33619

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 8
Earliest

J:31839 Frattini A, et al., The chromosome localization and the HCF repeats of the human host cell factor gene (HCFC1) are conserved in the mouse homologue. Genomics. 1996 Mar 1;32(2):277-80
Latest

J:287843 Tian E, et al., Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Proc Natl Acad Sci U S A. 2019 Dec 10;116(50):25196-25202

TSS for Renbp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr163602	ChrX:72974440-72974457 (-)	-41 bp
Tssr163601	ChrX:72974357-72974429 (-)	15 bp
Tssr163600	ChrX:72974341-72974356 (-)	59 bp
Tssr163599	ChrX:72974323-72974334 (-)	79 bp
Tssr163598	ChrX:72974126-72974138 (-)	276 bp
Tssr163597	ChrX:72971698-72971707 (-)	2,705 bp
Tssr163596	ChrX:72971646-72971663 (-)	2,753 bp
Tssr163595	ChrX:72971602-72971626 (-)	2,794 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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