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Hcfc1 Gene Detail
Summary
  • Symbol
    Hcfc1
  • Name
    host cell factor C1
  • Synonyms
    HCF-1, HCF1, VP16 accessory protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:105942
    NCBI Gene: 15161
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:72986398-73009963 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 37.52 cM, cytoband C1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105942
 protein coding gene ChrX:72986398-73011430 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035828
 protein coding gene ChrX:69726867-69750436 (-)
A/J MGP_AJ_G0035809
 protein coding gene ChrX:69923288-69946831 (-)
AKR/J MGP_AKRJ_G0035734
 protein coding gene ChrX:71767027-71790594 (-)
BALB/cJ MGP_BALBcJ_G0035794
 protein coding gene ChrX:68947105-68970669 (-)
C3H/HeJ MGP_C3HHeJ_G0035499
 protein coding gene ChrX:70201432-70224982 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036324
 protein coding gene ChrX:71872931-71896493 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033168
 protein coding gene ChrX:68950971-68974594 (-)
CAST/EiJ MGP_CASTEiJ_G0034790
 protein coding gene ChrX:55551447-55576707 (-)
CBA/J MGP_CBAJ_G0035474
 protein coding gene ChrX:73865931-73892413 (-)
DBA/2J MGP_DBA2J_G0035631
 protein coding gene ChrX:69374980-69399268 (-)
FVB/NJ MGP_FVBNJ_G0035575
 protein coding gene ChrX:68716488-68740306 (-)
LP/J MGP_LPJ_G0035716
 protein coding gene ChrX:70509271-70532835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035613
 protein coding gene ChrX:76419857-76443409 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036346
 protein coding gene ChrX:69550228-69573773 (-)
PWK/PhJ MGP_PWKPhJ_G0034489
 protein coding gene ChrX:53559176-53582923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034323
 protein coding gene ChrX:56449147-56472934 (-)
WSB/EiJ MGP_WSBEiJ_G0034931
 protein coding gene ChrX:68820759-68844859 (-)



Homology
more
  • Human Ortholog
    HCFC1, host cell factor C1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HCFC1, host cell factor C1
  • Synonyms
    CFF, HCF, HCF-1, HCF1, HFC1, MAHCX, MRX3, PPP1R89, VCAF, XLID3
  • Links
    NCBI Gene ID: 3054
    neXtProt AC: NX_P51610
    UniProt: P51610

  • Chr Location
    Xq28; chrX:153947557-153971818 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hcfc1 mouse models; 1 with human HCFC1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Conditional loss of the maternally inherited allele is embryonic lethal with increased apoptosis and reduced cell proliferation. Liver-specific knockout leads to decreased liver regeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    28
  • cDNA Data
    24
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031386 Ensembl Gene Model | MGI Sequence Detail 23566 C57BL/6J ±  kb
    transcript ENSMUST00000114372 Ensembl | MGI Sequence Detail 8262 Not Applicable  
    polypeptide ENSMUSP00000110012 Ensembl | MGI Sequence Detail 2090 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 6
      cDNA 24
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-33621, MGI:2147992
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 16
      Phenotypes 6
    • Earliest
      J:50113 Taylor KD, et al., Patterns of mRNA prevalence and expression of B1 and B2 transcripts in early mouse embryos. Development. 1987 Dec;101(4):877-92
    • Latest
      J:342808 Arbuckle JH, et al., Deletion of the Transcriptional Coactivator HCF-1 In Vivo Impairs the Removal of Repressive Heterochromatin from Latent HSV Genomes and Suppresses the Initiation of Viral Reactivation. mBio. 2023 Feb 28;14(1):e0354222
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory